Characterization of neuromyelitis optica and neuromyelitis optica spectrum disorder patients with a late onset

Abstract

LONMO/LONMOSD is particularly severe, with a high rate of motor impairment and death.

Two Cases of Very-Late-Onset Neuromyelitis Optica Spectrum Disorder (NMOSD) in Patients over the Age of 80

“…We report 2 cases of very-late-onset NMOSD in patients over the age of 80 with transverse myelopathy as the initial manifestation. NMOSD is an inflammatory demyelinating disease of the central nervous system affecting predominantly women, most frequently in their 30s to 40s [1][2][3][4][5]. NMOSD has been described in elderly patients [6][7][8][9]; however, very-late-onset NMOSD in patients over the age of 80 is extremely rare.…”

“…Neuromyelitis optica (NMO) is a rare inflammatory demyelinating disease of the central nervous system affecting predominantly women, most frequently in their 30s to 40s [1][2][3][4][5]. The anti-aquaporin-4 (AQP4) antibody has been identified as a disease-specific autoantibody in NMO patients [1][2][3][4][5]. NMO and its incomplete forms are referred to as NMO spectrum disorders (NMOSD) [1][2][3][4][5].…”

“…The anti-aquaporin-4 (AQP4) antibody has been identified as a disease-specific autoantibody in NMO patients [1][2][3][4][5]. NMO and its incomplete forms are referred to as NMO spectrum disorders (NMOSD) [1][2][3][4][5]. Very-late-onset NMOSD in patients over the age of 80 has only rarely been reported.…”

Case of neuromyelitis optica with recurrent stomach carcinoma

“…Although the characteristics of the present case suggest the possible coexistence with recurrent stomach cancer, evidence of causal relationships between the onset of NMO and cancer has yet to be established. However, the proportion of patients with late‐onset (≥50 years) NMOSD is higher than that for multiple sclerosis . The clinical manifestation of late‐onset NMOSD patients was reported to be different from that of those with early‐onset NMOSD in terms of severity, with a high rate of motor impairment and death .…”

Tonic spasms and short myelitis in an elderly woman—unique onset of neuromyelitis optica

“…However, it is increasingly recognised in older people (as high as 23% in a large cohort) 8. Thus, neuromyelitis optica is an important cause of myelitis in an older person.…”