Characterization of new membrane materials by means of fouling experiments Adsorption of bsa on polyetherimide—polyvinylpyrrolidone membranes

Abstract

The hydrophilicity of polyetherimide-polyvinylpyrrolidone (PEI-PVP) microfiltration membranes can be adjusted by means of a suitable post-treatment.The influence of the nature of the membrane surface on fouling properties was studied using permeation experiments before and after exposure to a protein (BSA) solution and adsorption experiments with i*C labelled BSA. A correlation between the permeation experiments and the radiolabelled BSA adsorption experiments was found. The PVP in the membrane matrix prevents BSA adsorption taking place to a large extent and it appeared that heat-treated PEI-PVP membranes showed the same nonfouling behaviour as, for example, cellulose acetate membranes.

Polymeric microsieves produced by phase separation micromolding

“…of suppressing macrovoid formation and increase hydrophilicity and pore interconnectivity [22][23][24]. On the other hand, membranes with hydrophilic additives like PVP are desirable for applications where low protein adsorption is required [25,26].…”

Low-biofouling membranes prepared by liquid-induced phase separation of the PVDF/polystyrene-b-poly (ethylene glycol) methacrylate blend

“…Furthermore, modification of the physical structure, especially the surface porosity, may be responsible for permeability decline. Finally, the third type of method involves the blending method associated to a phase separation process [12][13][14]. These methods are convenient and readily carried out.…”

Polymer Membrane and Cell Models for Drug Discovery

“…In practical application, water soluble polymers of PEG and PVP [48], charged polymers of sulfonated materials [49,50] and other hydrophilic polymers including poly(vinyl alcohol) [51], poly(ether imide) [52] and poly(methylacrylamide) [53], etc. can be used as additives to homogeneously blend with the key membrane materials for preparation of hydrophilic membranes.…”