Characterization of Newcastle disease virus vaccines by biological properties and sequence analysis of the hemagglutinin-neuraminidase protein gene

Seal, Bruce S.; King, Daniel J.; Bennett, Joyce D.

doi:10.1016/0264-410x(95)00252-v

Cited by 19 publications

(12 citation statements)

References 23 publications

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“…The isolates from each different periodic epizootics in Korea were not identical in origin, based on the sequence analysis and phylogenetic relationships. In the present study, the phylogenetic analysis of partial F gene sequence produced similar tree topology compared with those from entire gene sequences as shown in previous studies Toyoda et al, 1989;Seal et al, 1995Seal et al, , 1996Lomniczi et al, 1998;Yang et al, 1999;Yu et al, 2001). Lomniczi et al (1998) proposed that at least three different genotypes (II, III and IV) were responsible for the epizootics during the first panzootic (before the 1960s), each one being restricted to a specific geographical region (Herczeg et al, 1999).…”

Section: Discussionsupporting

confidence: 86%

“…Various methods have been introduced for grouping and analysis of NDV including differences in pathogenicity (Alexander, 1997), antigenicity (Russell & Alexander, 1983;Alexander et al, 1987Alexander et al, , 1997, and genomes (Collins et al, 1993;Jarecki-Black & King, 1993;Seal et al, 1995Seal et al, , 1996Seal et al, , 2000Ballagi-Pordany et al, 1996;Marin et al, 1996;Kant et al, 1997;Lomniczi et al, 1998;Herczeg et al, 1999Herczeg et al, , 2001Yang et al, 1999;Nanthakumar et al, 2000;Aldous et al, 2001Aldous et al, , 2003Gould et al, 2001;Ke et al, 2001;Yu et al, 2001;Liang et al, 2002;Mase et al, 2002;Liu et al, 2003;Wehmann et al, 2003a,b). Several epidemiological studies of NDV have been carried out using molecular-based methods.…”

Section: Introductionmentioning

confidence: 99%

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Molecular epidemiology of Newcastle disease viruses isolated in South Korea using sequencing of the fusion protein cleavage site region and phylogenetic relationships

Lee¹,

Sung²,

Choi³

et al. 2004

Avian Pathology

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Molecular epidemiology of Newcastle disease viruses isolated in South Korea using sequencing of the fusion protein cleavage site region and phylogenetic relationships

Lee¹,

Sung²,

Choi³

et al. 2004

Avian Pathology

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“…Such a change, however, is most improbable. According to virological studies, NDV and its genetically distinct strains, of which MTH‐68/H is one, exhibit a high degree of genetic stability (44, 45). Furthermore, the histological study of the rhombencephalic tumor documents clearly the oncolytic activity of MTH‐68/H by the demonstration of numerous apoptotic tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Combined treatment of pediatric high‐grade glioma with the oncolytic viral strain MTH‐68/H and oral valproic acid

Wagner

Csatary

Gosztonyi

et al. 2006

APMIS

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The case of a 12-year-old boy with anaplastic astrocytoma of the left thalamus is reported. Postoperative irradiation and chemotherapy could not repress tumor progression; therefore, treatment was undertaken with an oncolytic virus, MTH-68/H, an attenuated strain of Newcastle disease virus (NDV), and valproic acid (VPA), an antiepileptic drug, which also has antineoplastic properties. This treatment resulted in a far-reaching regression of the thalamic glioma, but 4 months later a new tumor manifestation, an extension of the thalamic tumor, appeared in the wall of the IVth ventricle, which required a second neurosurgical intervention. Under continuous MTH-68/H - VPA administration the thalamic tumor remained under control, but the rhombencephalic one progressed relentlessly and led to the fatal outcome. In the final stage, a third tumor manifestation appeared in the left temporal lobe. The possible reasons for the antagonistic behavior of the three manifestations of the same type of glioma to the initially most successful therapy are discussed. The comparative histological study of the thalamic and rhombencephalic tumor manifestations revealed that MTH-68/H treatment induces, similar to in vitro observations, a massive apoptotic tumor cell decline. In the rhombencephalic tumor, in and around the declining tumor cells, NDV antigen could be demonstrated immunohistochemically, and virus particles have been found in the cytoplasm of tumor cells at electron microscopic investigation. These findings document that the oncolytic effect of MTH-68/H treatment is the direct consequence of virus presence and replication in the neoplastic cells. This is the first demonstration of NDV constituents in an MTH-68/H -treated glioma.

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“…All would be placed in the rapid elution group [4,45]. Others [18] have also described rapid elution of the HN spikes.…”

Section: Discussionmentioning

confidence: 99%

“…Considering the failure to completely sensitize [26] and the known differences [4,40,43,45], the B1 vaccine was compared with strain 575. The 16th passage in eggs [4] was obtained from the late F.B.…”

Section: Ndv Strains 575 and B1 Antisera Rbc And Sensitization Of Rbcmentioning

confidence: 99%

Agglutination-separation reactions of red blood cells sensitized with Newcastle disease virus: quantities, agglutination characteristics, and serology of altered virus and HN spikes released following neuraminidase reactivation

Graves

2001

Vet. Res.

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-Red blood cells (RBC) become sensitized following the elution of strain 575 Newcastle disease virus (NDV). The neuraminidase (NA) in the haemagglutinin (HA)-sialic acid configuration is inactive. The HA on sensitized RBC agglutinates normal RBC. The sialic acid on normal RBC initiated reactivation of the NA-a newly described function. Then normal-sensitized RBC agglomerates separated at 37 o C in the irreversible agglutination-separation (AS) reactions. With separation the AS products, HN spikes (150-200 kDa) and altered NDV, which contain fewer HN spikes than intact allantoic NDV, were removed from the sensitized RBC and the NDV membrane. Extraction of HN spikes from the membrane required more sialic acid than the removal of AS products from RBC. Thus 2 reactions were delineated for the orderly removal. Amounts of each released AS product suggest the source of the HN spikes. AS reactions and ether treatment of NDV increased the HA titres up to 19.2 fold. HA-sialic acid configurations were estimated by the amounts of normal RBC agglutinated by sensitized RBC and also by agglutination with fetuin. Elution of B1 vaccine, HN spikes from ether-treated NDV as well as AS products separated on sephadex resulted in incompletely sensitized RBC; fewer configurations were titrated with normal RBC; all failed to respond to anti-NA antibody. In contrast, sensitized RBC or suspensions of 575 NDV, but not the B1 vaccine strain, responded to both anti-NA and anti-HA antibody. Sensitization, slow elution, and responding to anti-NA antibody, which was accompanied by fluorescent foci on sensitized RBC, required intact NDV and the infrequent HA-sialic acid configuration. The NA was inactive for the HA-sialic acid configuration but cleaved fetuin, indicating substrate specificity. An inactive NA would allow time for fusion and NDV penetration rather than elution by an active NA early in NDV infection.Newcastle disease virus / agglutination-separation reactions of sensitized RBC / neuraminidase reactivation / new sialic acid function / HN serologic configurations Vet. Res. 32 (2001) 475-489 475

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Characterization of Newcastle disease virus vaccines by biological properties and sequence analysis of the hemagglutinin-neuraminidase protein gene

Cited by 19 publications

References 23 publications

Molecular epidemiology of Newcastle disease viruses isolated in South Korea using sequencing of the fusion protein cleavage site region and phylogenetic relationships

Molecular epidemiology of Newcastle disease viruses isolated in South Korea using sequencing of the fusion protein cleavage site region and phylogenetic relationships

Combined treatment of pediatric high‐grade glioma with the oncolytic viral strain MTH‐68/H and oral valproic acid

Agglutination-separation reactions of red blood cells sensitized with Newcastle disease virus: quantities, agglutination characteristics, and serology of altered virus and HN spikes released following neuraminidase reactivation

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