Characterization of Nme6-like gene/protein from marine sponge Suberites domuncula

Perina, Drago; Bosnar, Maja Herak; Mikoč, Andreja; Müller, Wernér E.G.; Ćetković, Helena

doi:10.1007/s00210-011-0635-9

Cited by 15 publications

(15 citation statements)

References 39 publications

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“…This is in accordance with merely eight microRNAs (miRNAs) identified in the sponge A. queenslandica , which may indicate that metazoan complexity correlates with an increasing number of miRNAs [22]. The observation that recent introns, which are present in the human Nme6 gene, but not in the sponge ortholog, contain miRNAs also supports that thesis [23]. snoRNAs are believed to be the most ancient ncRNAs [24].…”

Section: Introductionsupporting

confidence: 72%

Structural and Functional Characterization of Ribosomal Protein Gene Introns in Sponges

et al. 2012

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Ribosomal protein genes (RPGs) are a powerful tool for studying intron evolution. They exist in all three domains of life and are much conserved. Accumulating genomic data suggest that RPG introns in many organisms abound with non-protein-coding-RNAs (ncRNAs). These ancient ncRNAs are small nucleolar RNAs (snoRNAs) essential for ribosome assembly. They are also mobile genetic elements and therefore probably important in diversification and enrichment of transcriptomes through various mechanisms such as intron/exon gain/loss. snoRNAs in basal metazoans are poorly characterized. We examined 449 RPG introns, in total, from four demosponges: Amphimedon queenslandica, Suberites domuncula, Suberites ficus and Suberites pagurorum and showed that RPG introns from A. queenslandica share position conservancy and some structural similarity with “higher” metazoans. Moreover, our study indicates that mobile element insertions play an important role in the evolution of their size. In four sponges 51 snoRNAs were identified. The analysis showed discrepancies between the snoRNA pools of orthologous RPG introns between S. domuncula and A. queenslandica. Furthermore, these two sponges show as much conservancy of RPG intron positions between each other as between themselves and human. Sponges from the Suberites genus show consistency in RPG intron position conservation. However, significant differences in some of the orthologous RPG introns of closely related sponges were observed. This indicates that RPG introns are dynamic even on these shorter evolutionary time scales.

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Section: Introductionsupporting

confidence: 72%

Structural and Functional Characterization of Ribosomal Protein Gene Introns in Sponges

et al. 2012

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“…NME6 is an inhibitor of TP53-induced apoptosis and its down-regulation should enhance TP53 apoptotic function. Moreover, nucleoside diphosphate kinases are evolutionarily conserved enzymes involved in many biological processes such as metastasis, proliferation, development, differentiation, vesicle transport, and apoptosis in vertebrates, but molecular mechanisms of these processes are still largely unknown [33,34].…”

Section: Discussionmentioning

confidence: 99%

Acute L-glutamine deprivation affects the expression of TP53-related protein genes in U87 glioma cells

Minchenko¹,

Danilovskyi²,

Kryvdiuk³

et al. 2014

Fiziol Zh

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Acute L-glutamine deprivation affects the expression of tP53-related protein genes in u87 glioma cells We have studied the effect of acute L-glutamine deprivation on the expression of tumor protein 53 (TP53)related genes such as TOPORS (topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase), TP53BP1 (TP53 binding protein 1), TP53TG1 (TP53 inducible gene 1), SESN1 (p53 regulated PA26 nuclear protein), NME6 (NME/NM23 nucleoside diphosphate kinase 6), and ZMAT3 (zinc finger, Matrin-type 3) in glioma cells with ERN1 knockdown. It was shown that blockade of ERN1 function in U87 glioma cells is induced the expression of RYBP and SESN1 genes, but decreased the expression of TP53BP1, TP53TG1, TOPORS, NME6, genes. Moreover, the expression levels of RYBP, SESN1, TP53BP1, and ZMAT3 genes is increased in control glioma cells by L-glutamine deprivation condition but blockade of ERN1 signaling enzyme function significantly enhances this effect on the expression all of these genes. At the same time, the ERN1 knockdown eliminates the response TP53TG1 and TOPORS genes to L-glutamine deprivation condition. Results of this investigation clearly demonstrate that the expression most of genes encoding TP53-related factors depends upon acute L-glutamine deprivation condition as well as upon ERN1, the major signaling system of the endoplasmic reticulum stress.

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“…However, it is not clear whether these substances are produced to protect the organism from potential carcinogens, or for a completely different ecological or physiological purpose. Most genes and pathways implicated in human genetic diseases and in neoplasia development and progression are highly conserved throughout evolution and can be found in early-branching metazoans such as non-bilaterians or even unicellular eukaryotes [19,28,[130][131][132][133][134][135][136][137][138][139]. This is probably due to the fact that most human diseases developed by abusing or distorting basic cellular processes common to all living beings.…”

Section: Metastasis-suppressor Genes Have Diverse Evolutionary Historiesmentioning

confidence: 99%

A survey of metastasis suppressors in Metazoa

Ćetković

Harcet

Roller

et al. 2018

Laboratory Investigation

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Metastasis suppressors are genes/proteins involved in regulation of one or more steps of the metastatic cascade while having little or no effect on tumor growth. The list of putative metastasis suppressors is constantly increasing although thorough understanding of their biochemical mechanism(s) and evolutionary history is still lacking. Little is known about tumor-related genes in invertebrates, especially non-bilaterians and unicellular relatives of animals. However, in the last few years we have been witnessing a growing interest in this subject since it has been shown that many disease-related genes are already present in simple non-bilateral animals and even in their unicellular relatives. Studying human diseases using simpler organisms that may better represent the ancestral conditions in which the specific disease-related genes appeared could provide better understanding of how those genes function. This review represents a compilation of published literature and our bioinformatics analysis to gain a general insight into the evolutionary history of metastasis-suppressor genes in animals (Metazoa). Our survey suggests that metastasis-suppressor genes emerged in three different periods in the evolution of Metazoa: before the origin of metazoans, with the emergence of first animals and at the origin of vertebrates.

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Characterization of Nme6-like gene/protein from marine sponge Suberites domuncula

Cited by 15 publications

References 39 publications

Structural and Functional Characterization of Ribosomal Protein Gene Introns in Sponges

Structural and Functional Characterization of Ribosomal Protein Gene Introns in Sponges

Acute L-glutamine deprivation affects the expression of TP53-related protein genes in U87 glioma cells

A survey of metastasis suppressors in Metazoa

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