Characterization of novel human papillomavirus types 157, 158 and 205 from healthy skin and recombination analysis in genus γ-Papillomavirus

Bolatti, Elisa Maria; Chouhy, Diego; Casal, Pablo E.; Pérez, Germán; Stella, Emma J.; Sánchez, A.; Gorosito, Mario; Bussy, Ramón Fernández; Giri, Adriana A.

doi:10.1016/j.meegid.2016.04.018

Cited by 19 publications

(13 citation statements)

References 60 publications

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“…We speculated that the E1 insertion in CPV9 identified in this study might be due to the occasional inter-species and intra-species recombination events of PVs [43,44]. The recombination of the E1 gene among HPV157, HPV158, and HPV209 has been demonstrated in HPVs [45]. Further investigations should study the potential evidence of inter-species recombination of CPVs.…”

Section: Discussionmentioning

confidence: 74%

Whole Genomic Analysis and Comparison of Two Canine Papillomavirus Type 9 Strains in Malignant and Benign Skin Lesions

Chang

Yamashita‐Kawanishi

Tomizawa

et al. 2020

Viruses

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Papillomaviruses (PVs) usually cause benign proliferative lesions in the stratified epithelium of various animal species. However, some high-risk types of PVs have been proven to lead to malignant transformations. In dogs, several canine papillomaviruses (CPVs) have been identified in malignant lesions and are suggested as one of the risk factors for the development of squamous cell carcinomas (SCCs). In the present study, the full genomes of two CPV9 strains from recurrent SCCs of Dog 1 and skin viral papilloma (viral plaque) of Dog 2 were sequenced. Alignment of the two CPV9 sequences with the genome of the reference CPV9 strain (accession no. JF800656.1) derived from a solitary pigmented plaque was performed. Compared with the reference strain, a 27 bp in-frame insertion in the E1 gene was identified in both CPV9 strains in this study. In comparison with the CPV9 strains derived from benign lesions, the CPV9 from the SCCs of Dog 1 exhibited a 328 bp deletion at the 3′ end of the E2 and spacer sequence, which encoded a truncated deduced E2 protein and a chimeric E8^E2 protein. However, there was no difference in the mRNA expression levels of viral oncoproteins of E6 and E7 between the two CPV9 cases, suggesting that the oncogenesis of CPV9 for malignant transformation might be different from that of human papillomaviruses. The roles of E2 and E8^E2 deleted CPV9 in the oncogenesis of benign and malignant lesions should be further investigated.

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Section: Discussionmentioning

confidence: 74%

Whole Genomic Analysis and Comparison of Two Canine Papillomavirus Type 9 Strains in Malignant and Benign Skin Lesions

Chang

Yamashita‐Kawanishi

Tomizawa

et al. 2020

Viruses

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“…Other domains are the PDZ binding domain in the N-terminal of E6 [52], the ATP binding site of E1, the DNA recognition helix of E2 and the furin cleavage site of L2. All these domains play a role in HPV life cycle, the details of the mechanisms of their action are beyond the scope of this paper.…”

Section: Discussionmentioning

confidence: 99%

Discovery, characterisation and genomic variation of six novel Gammapapillomavirus types from penile swabs in South Africa

Murahwa

Meiring

Mbulawa

et al. 2019

Papillomavirus Research

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Six novel human papillomaviruses from penile swabs were characterised. Multiple full genome clones for each novel type were generated, and complete genome sizes were: HPV211 (7253bp), HPV212 (7208bp), HPV213 (7096bp), HPV214 (7357), HPV215 (7186bp) and HPV216 (7233bp). Phylogenetically the novel papillomaviruses all clustered with Gammapapillomaviruses: HPV211 is most closely related to HPV168 (72% identity in the L1 nucleotide sequence) of the Gamma-8 species, HPV212 is most closely related to HPV144 (82.9%) of the Gamma-17 species, HPV213 is most closely related to HPV153 (71.8%) of the Gamma-13 species, HPV214 is most closely related to HPV103 (75.3%) of the Gamma-6 species, HPV215 and HPV216 are most closely related to HPV129 (76.8% and 79.2% respectively) of the Gamma-9 species. The novel HPV types demonstrated the classical genomic organisation of Gammapapillomavirusess, with seven open reading frames (ORFs) encoding five early (E1, E2, E4, E6 and E7) and two late (L1 and L2) proteins. Typical of Gammapapillomavirusess the novel types all lacked the E5 ORF and HPV214 also lacked the E6 ORF. HPV212 had nine unique variants, HPV213 had five and HPV215 had four variants. Conserved domains observed among the novel types are the Zinc finger Binding Domain and PDZ domains. A retinoblastoma binding domain (pRB) binding domain in E7 protein was additionally identified in HPV214. This study expands the knowledge of the rapidly growing Gammapapillomavirus genus.

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“…of the reference strains and their abbrevation were showed in the trees. The strain determined in this study was marked with a triangle detection locations ranging from health skin and cutaneous lesions to genital lesions [10,14,15]. DNA of some Gamma-PVs types were detected in skin cancer raised concerns of some Gamma-PVs associations with cancers, especially in patients with immunodeficiency or immunosuppression [16,17].…”

Section: Resultsmentioning

confidence: 87%

Genomic organization of a Gamma-6 papillomavirus metagenomic discovered from vaginal swab samples of Chinese pregnant women

Ling

Wang

Yin³

et al. 2020

Virol J

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A complete genome sequence of human papillomaviruses (HPV) named as HPV-ujs-21015 was determined by viral metagenomic and PCR methods. The complete genome is 7354 bp in length with GC content of 41.7%, of which the genome was predicted to contain six ORFs (Open Reading Frame, ORF) coding for four early proteins (E7, E1, E4, and E2) and two late proteins (L1 and L2). Phylogenetic analysis based on the complete genome and the L1 protein showed that HPV-ujs-21015 belongs to a type 214 member within genus Gamma-6 papillomavirus. It is the first complete genome of Gamma-6 papillomavirus discovered from pregnant women in China.

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Characterization of novel human papillomavirus types 157, 158 and 205 from healthy skin and recombination analysis in genus γ-Papillomavirus

Cited by 19 publications

References 60 publications

Whole Genomic Analysis and Comparison of Two Canine Papillomavirus Type 9 Strains in Malignant and Benign Skin Lesions

Whole Genomic Analysis and Comparison of Two Canine Papillomavirus Type 9 Strains in Malignant and Benign Skin Lesions

Discovery, characterisation and genomic variation of six novel Gammapapillomavirus types from penile swabs in South Africa

Genomic organization of a Gamma-6 papillomavirus metagenomic discovered from vaginal swab samples of Chinese pregnant women

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