1980
DOI: 10.1111/j.1365-2141.1980.tb01205.x
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Characterization of Null Cells in Chronic Lymphocytic Leukaemia with B‐Cell Allo‐ and Hetero‐antisera

Abstract: Chronic lymphocytic leukaemia peripheral blood mononuclear cells (CLL-PBMN) were separated into B, T and Null-enriched lymphocyte sub-populations using sequential mouse and sheep red blood cell rosetting depletions on Hypaque-Ficoll gradients. The procedure produced viable cell populations with mean percentage purities of 90, 87 and 75 for B, T and non-rosetting (Null-enriched) sub-populations, respectively. More than 80% of PBMN cells were generally accounted for by mouse and sheep rosetting. The purified lym… Show more

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Cited by 3 publications
(2 citation statements)
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“…A similar expansion of null cells after treatment has been reported elsewhere [33]. Kirov et al [22] have observed B cell antigens on the surface of null cells derived from patients with CLL, suggesting that these cells may be a subset of B cells. Assuming that the expanded null cell population is still malignant, the abnormal AMLR seen in these patients could also be related to a poor stimulatory capacity of these cells.…”
Section: J R Quesada Et Al: Amlr In Lymphoid Malignanciessupporting
confidence: 54%
“…A similar expansion of null cells after treatment has been reported elsewhere [33]. Kirov et al [22] have observed B cell antigens on the surface of null cells derived from patients with CLL, suggesting that these cells may be a subset of B cells. Assuming that the expanded null cell population is still malignant, the abnormal AMLR seen in these patients could also be related to a poor stimulatory capacity of these cells.…”
Section: J R Quesada Et Al: Amlr In Lymphoid Malignanciessupporting
confidence: 54%
“…It does appear, though, that CLL BFU-e in the peripheral blood null cell fraction of the early stage untreated Bcell CLL patients we studied were decreased in concentration. This may be secondary to expansion of the null cell fraction in CLL patients by pre-B cells as previously reported [38]. Accordingly, the absolute number of peripheral blood BFU-e in B cell CLL was normal or increased.…”
Section: Discussionsupporting
confidence: 68%