2009
DOI: 10.1007/s10565-009-9131-0
|View full text |Cite
|
Sign up to set email alerts
|

Characterization of ochratoxin A-induced apoptosis in primary rat hepatocytes

Abstract: The main target organ of the mycotoxin ochratoxin A (OTA) in mammals is the kidney but OTA has also been shown to be hepatotoxic in rats and to induce tumors in mouse liver. Even at very low concentrations, OTA causes perturbations of cellular signaling pathways as well as enhanced apoptosis. OTA has been extensively studied in kidney cell systems. Since this substance also affects liver health, we focused our work on apoptosis-related events induced by OTA in primary rat hepatocytes. We performed pathway-spec… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

5
27
0

Year Published

2011
2011
2024
2024

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 43 publications
(32 citation statements)
references
References 55 publications
5
27
0
Order By: Relevance
“…1), that in accordance with Chopra et al, (2010); while inhibition was monitored in OTA/GSH (Plate D, Fig. 2), GSH+OTA (Plate D, Fig.…”
Section: Plate (B)supporting
confidence: 77%
See 2 more Smart Citations
“…1), that in accordance with Chopra et al, (2010); while inhibition was monitored in OTA/GSH (Plate D, Fig. 2), GSH+OTA (Plate D, Fig.…”
Section: Plate (B)supporting
confidence: 77%
“…3) that could be attributed to maintenance of plasma glutathione pool and subsequently cellular pool; so blocking of caspase-3 activities due to glutathionylation of cysteine residue in caspase molecules, with hindering its activation so block the apoptosis-dependent caspacse-3 cascade (Huang et al, 2008). Caspase-3 inhibition led to a significant but not complete reduction of OTA-induced apoptosis, which in agreement with Chopra et al, (2010) and give a chance for incorporation of other factor, but keep the prominent role of caspase-3 cascade.…”
Section: Plate (B)supporting
confidence: 73%
See 1 more Smart Citation
“…At low doses, OTA required more time to induce apoptosis in H9 cells (data not shown). Several mechanisms are associated with OTA-induced apoptosis, including protein and mRNA synthesis inhibition, oxidative stress, cell signaling pathway alteration and disruption of the balance of the pro-and anti-apoptotic Bcl-2 protein family (Chopra et al, 2010). Oxidative stress is often cited as a key mechanism in OTA-induced apoptosis in different cell types (Marin-Kuan et al, 2011): it has been reported that OTA accelerates reactive oxygen species (ROS) formation by lipid peroxidation and the inhibition of antioxidant enzymes such as superoxide dismutase.…”
Section: Discussionmentioning
confidence: 99%
“…Compared with necrosis, a passive process, apoptosis is an active metabolic performance which is executed along determined pathways (Günther et al, 2013). Because of this, the cell is subject to strict (self) control and is eliminated without affecting neighboring cells (Chopra et al, 2010). Three main components are involved in apoptosis signal transduction: mitochondrial pathway (Zhang et al, 2010), death receptor pathway (Nebbioso et al, 2011) and endoplasmic reticulum pathway (Zhang and Kaufman, 2008).…”
Section: Introductionmentioning
confidence: 99%