Characterization of operant social interaction in rats: effects of access duration, effort, peer familiarity, housing conditions, and choice between social interaction vs. food or remifentanil

Chow, Jonathan J.; Beacher, Nicholas J.; Chabot, Jules M; Oke, Marvellous; Vènniro, Marco; Lin, Da-Ting; Shaham, Yavin

doi:10.1007/s00213-022-06064-1

Cited by 32 publications

(37 citation statements)

References 56 publications

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“…Second, in contrast to cocaine dose manipulations, experimental manipulations intended to alter the magnitude of social interaction as a reinforcer did not significantly alter cocaine-vs-social choice. These results were concordant with recent results demonstrating that social-access time was not a significant factor in operant responding for social interaction (Baldwin et al, 2022;Chow et al, 2022). Finally, non-contingent "sample" presentation of reinforcers before the discrete-choice trials did not significantly impact cocaine-vs-social choice.…”

Section: Discussionsupporting

confidence: 91%

“…Social interaction was chosen over no or small cocaine doses, and a large cocaine dose was chosen over social interaction. The sensitivity of cocaine-vs-social interaction choice to manipulations of drug reinforcer magnitude is consistent with previous cocaine-vs-food choice results using discrete-trial choice procedures (Johnson et al, 2016;Lile et al, 2016;Nader and Woolverton, 1992), non-discrete-trial choice procedures (Negus, 2003;Thomsen et al, 2013), and opioid-vs-social interaction choice studies (Chow et al, 2022).…”

Section: Cocaine Was Chosen Over Social Interaction Under a Pr Schedulesupporting

confidence: 87%

“…Since prior literature indicates that social interaction maintains lower levels of operant responding relative to food reinforcers (Baldwin et al, 2022;Chow et al, 2022), the ratio requirement on the social lever was held constant at FR3 during all trials to facilitate maintenance of social responding. If a rat failed to complete a ratio requirement within the 10min trial period, the trial terminated, a 30-s time out period ensued, the trial was counted as an omission, and the ratio requirement did not increment for the next trial.…”

Section: Progressive-ratio Cocaine-vs-social Choicementioning

confidence: 99%

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Effects of environmental manipulations on cocaine-vs-social choice in male and female rats

Marcus¹,

Negus²,

Banks³

2022

Pharmacology Biochemistry and Behavior

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Section: Discussionsupporting

confidence: 91%

Section: Cocaine Was Chosen Over Social Interaction Under a Pr Schedulesupporting

confidence: 87%

Section: Progressive-ratio Cocaine-vs-social Choicementioning

confidence: 99%

See 1 more Smart Citation

Effects of environmental manipulations on cocaine-vs-social choice in male and female rats

Marcus¹,

Negus²,

Banks³

2022

Pharmacology Biochemistry and Behavior

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“…Future studies may increase the magnitude of social interaction by increasing the amount of physical contact between rats during the social interaction period. The magnitude of the social reinforcer may also be increased by depriving rats of social interaction during adolescence (Ikemoto and Panksepp, 1992) or adulthood (Chow et al, 2022); however other studies suggest that social depravation during adolescence reduces the reinforcing magnitude of social interaction in adulthood (van den Berg et al, 1999). Future studies should evaluate the degree to which these and other environmental factors affect social reinforcer magnitude in a choice context.…”

Section: Discussionmentioning

confidence: 99%

“…The procedure consisted of nine choice trials to permit high response requirements that captured the cocaine breakpoint. Since prior literature indicates that social interaction maintains lower levels of operant responding relative to food reinforcers (Baldwin et al, 2022; Chow et al, 2022), the ratio requirement on the social lever was held constant at FR3 during all trials to facilitate maintenance of social responding. If a rat failed to complete a ratio requirement within the 10-min trial period, the trial terminated, a 30-s time out period ensued, the trial was counted as an omission, and the ratio requirement did not increment for the next trial.…”

Section: Methodsmentioning

confidence: 99%

Effects of environmental manipulations on cocaine-vs-social choice in male and female rats

Marcus

Negus

Banks

2022

Preprint

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Cocaine use disorder occurs in an environment where cocaine and other nondrug commodities are concurrently available. Preclinical drug-vs-nondrug choice procedures are one simplified method of modeling this complex clinical environment. The present study established a discrete-trial progressive-ratio (PR) cocaine-vs-social interaction choice procedure in male and female rats and determined sensitivity of choice behavior to manipulations of reinforcer magnitude and non-contingent “sample” reinforcer presentation. Rats could make up to nine discrete choices between an intravenous cocaine infusion (0.1 – 1.0 mg/kg/inf) and social interaction with a same-sex social “Partner” rat. Cocaine infusions were available under a PR schedule of reinforcement, and social interaction was available under a fixed-ratio (FR) 3 schedule. Social interaction was chosen over no or small cocaine doses (saline, 0.01 mg/kg/inf) and behavior was reallocated away from social and towards cocaine at larger cocaine doses (1.0 mg/kg/inf). Manipulating social interaction time as one method to alter social reinforcer magnitude did not significantly alter cocaine-vs-social choice. Removing the non-contingent reinforcer presentations before the discrete choice trials also failed to affect cocaine-vs-social choice, suggesting the time interval was sufficient to minimize any potential influence of the non-contingent cocaine infusions on subsequent choice behavior. Overall, the present results were consistent with previous drug-vs-social choice studies and extend our knowledge of environmental factors impacting drug-vs-social choice. Future studies determining the pharmacological sensitivity of cocaine-vs-social choice will be important in expanding the preclinical utility of these procedures for candidate medication drug development.

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Developmental trajectory of social reward motivation from early adolescence into adulthood in female and male Long‐Evans rats

Murray,

Logan,

Sheehan

et al. 2024

Developmental Psychobiology

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Most studies of adolescent and adult behavior involved one age group of each, whereas the dynamic changes in brain development suggest that there may be behavioral flux in adolescence. In two studies, we investigated developmental changes in social reward motivation in female and male Long‐Evans rats from prepuberty to early adulthood in a social operant conditioning task. Given the earlier onset of puberty in females than in males, we predicted the course of social reward development would differ between the sexes. Overall, the pattern of results from both studies suggests that the trajectory of social motivation across adolescence is characterized by upward and downward shifts that do not depend on the sex of the rats. During training, in both studies, the mean number of social gate openings and percentage of social gate openings was higher at P30 (prepubertal, early adolescence) and P50 (late adolescence) than at P40 (mid adolescence) and P70 (adulthood) irrespective of sex. Nevertheless, the specific age comparisons that were significant depended on the study. In both studies, P30 rats had greater levels of social motivation than did adults in accessing a social reward when increased effort was required (progressive ratio tests). In an extinction test, only P30 and P50 rats continued to show more nose‐pokes at the previously social gate than at the nonsocial gate, suggesting resistance to extinction. The results highlight the importance of characterizing behavior at several timepoints in adolescence to understand the neural mechanisms, many of which show similar discontinuities as they develop across adolescence.

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Characterization of operant social interaction in rats: effects of access duration, effort, peer familiarity, housing conditions, and choice between social interaction vs. food or remifentanil

Cited by 32 publications

References 56 publications

Effects of environmental manipulations on cocaine-vs-social choice in male and female rats

Effects of environmental manipulations on cocaine-vs-social choice in male and female rats

Effects of environmental manipulations on cocaine-vs-social choice in male and female rats

Developmental trajectory of social reward motivation from early adolescence into adulthood in female and male Long‐Evans rats

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