Characterization of Patients with Drugs and Toxins Associated Pulmonary Arterial Hypertension: A Clinical and Outcomes Perspective.

Snook, S.; Kudelko, Kristina; Spiekerkoetter, Edda; Haddad, François; Zamanian, R.T.

doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a4923

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“…Although in most cases, the actual pulmonary vascular histopathology of stimulant-induced PAH and iPAH is indistinguishable, the disease course itself may be different. Anecdotally, our group has documented a more aggressive disease course in stimulant associated PAH when compared with iPAH (14). Although currently registries, such as REVEAL may provide validation of our findings and furthermore insight into the complexities of D&T-APAH, it is likely that future, prospective multi-centred studies will be needed to better document specific type, length, and route of exposure.…”

Section: Current Limitations and Challengesmentioning

confidence: 59%

Drugs and toxins-associated pulmonary arterial hypertension: lessons learned and challenges ahead

Perez

Kudelko

Snook

et al. 2010

International Journal of Clinical Practice

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Since the identification of the link between pulmonary arterial hypertension (PAH) and exposure to certain drugs and toxins nearly fifty years ago, the expanding landscape of available pharmaceuticals and illicit drugs is further fueling this association. While some causative agents in drugs and toxins associated PAH (D&T-APAH) have been identified, little is known about the exact biology and clinical implications of the disease. In this review, we discuss the historical evidence that links PAH with exposure to anorexinogens, cocaine, and methamphetamines and concentrate on what is known about potential pathogenesis, clinical manifestations, and current management. We conclude that future research should focus on studies looking at clinical outcome and susceptibility factors.

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Section: Current Limitations and Challengesmentioning

confidence: 59%