Characterization of pH-responsive high molecular-weight chitosan/poly (vinyl alcohol) hydrogel prepared by gamma irradiation for localizing drug release

Vo, Tu Minh Tran; Piroonpan, Thananchai; Preuksarattanawut, Charasphat; Kobayashi, Takaomi; Potiyaraj, Pranut

doi:10.1186/s40643-022-00576-6

Cited by 21 publications

(7 citation statements)

References 59 publications

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“…The Higuchi equation is possibly the first model that quantifies drug release from thin films. Due to its simplicity [ 14 ], the Higuchi equation is widely used to correlate the kinetic of drugs released from various solid systems [ 8 , 15 , 16 , 17 , 18 , 19 , 20 ]. Th Higuchi equation has the following for:

where n t is the cumulative amount of the drug released at time t , while n max is the maximum amount of drug that can be released at an infinite time.…”

Section: Resultsmentioning

confidence: 99%

Cellulose Nanocrystals (CNCs) and Its Modified Form from Durian Rind as Dexamethasone Carrier

et al. 2022

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In this study, CNCs were extracted from durian rind. Modification to CNCs with saponin was conducted at 50 °C for one h. CNCs and CNCs-saponin were employed as dexamethasone carriers. Modification to CNCs using saponin did not change the relative crystallinity of CNCs. CNCs’ molecular structure and surface chemistry did not alter significantly after modification. Both nanoparticles have surface charges independently of pH. Dexamethasone-released kinetics were studied at two different pH (7.4 and 5.8). Higuchi, Ritger–Peppas, first-order kinetic and sigmoidal equations were used to represent the released kinetic data. The sigmoidal equation was found to be superior to other models. The CNCs and CNCs-saponin showed burst release at 30 min. The study indicated that cell viability decreased by 30% after modification with saponin.

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where n t is the cumulative amount of the drug released at time t , while n max is the maximum amount of drug that can be released at an infinite time.…”

Section: Resultsmentioning

confidence: 99%

Cellulose Nanocrystals (CNCs) and Its Modified Form from Durian Rind as Dexamethasone Carrier

et al. 2022

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“…It was found that drugloaded AM-O-β-CD showed a pH dependent drug release pro le. The drug release from the nanostructure in low pH was much higher due to Schiff base, high drug loading capacity and increase drug solubility [34] than the pure drug in the same environment.…”

Section: Characterization Of Drug Loaded Am-o-β-cd Nanoparticlementioning

confidence: 97%

Fabrication and Investigation of Oxidized-β-Cyclodextrin Nanoparticle as a Novel Class pH Responsive Drug Delivery Vehicle

Bergal,

Andac

2023

J Polym Environ

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Oxidized β-cyclodextrin (O-β-CD) nanoparticle was synthesized using oxidation process and Amoxicillin trihydrate (AMOX) model drug was integrated both via Schiff base reaction (C = N bond) as well as inclusion into cavity of O-β-CD to evaluate pH-responsive drug release behavior. The drug loaded nanocarrier (AM-O-β-CD) was characterized and results showed this formation, encapsulation and morphological change with average particle size (398 ± 8.51nm), negative zeta potential values (-25.4 ± 1.54) and high entrapment e ciency (86.1%).The in vitro release behavior of AM-O-β-CD was evaluated in physiological buffer conditions (0.1 M PBS, pH 5.2, at 37°C). It was found that drug-loaded AM-O-β-CD showed sustain, prolonged much higher drug release pro le (94.72%) in low pH than that of the pure drug (24.18%) in the same acidic medium.Release kinetics of drug loaded AM-O-β-CD was determined according to well-known mathematical models, revealing that in vitro release pro le could be best expressed by Higuchi kinetic model as release data showed the highest linearity (R 2 = 0.967) so that drug release takes place due to both dissolution and diffusion as it is expected.As a result, it has been proven that the nanostructure has the potential to be pH sensitive drug carrier, especially for drugs containing NH 2 side groups in acidic environments.

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“…The nanobeads composed of chitosan and agarose exhibit pH-sensitive releases of drugs, with different drug releases in tumor-simulated and normal cell-simulated buffers. Tran Vo et al [ 166 ] crosslinked chitosan/PVA hydrogels by using gamma irradiation. The higher swelling ratio of hydrogels was observed under acidic conditions, due to the protonation of amino groups.…”

Section: Pharmaceutical and Biomedical Applications Of Chitosan-based...mentioning

confidence: 99%

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Taokaew

Kaewkong

Kriangkrai

2023

Gels

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Chitosan is a promising naturally derived polysaccharide to be used in hydrogel forms for pharmaceutical and biomedical applications. The multifunctional chitosan-based hydrogels have attractive properties such as the ability to encapsulate, carry, and release the drug, biocompatibility, biodegradability, and non-immunogenicity. In this review, the advanced functions of the chitosan-based hydrogels are summarized, with emphasis on fabrications and resultant properties reported in literature from the recent decade. The recent progress in the applications of drug delivery, tissue engineering, disease treatments, and biosensors are reviewed. Current challenges and future development direction of the chitosan-based hydrogels for pharmaceutical and biomedical applications are prospected.

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Characterization of pH-responsive high molecular-weight chitosan/poly (vinyl alcohol) hydrogel prepared by gamma irradiation for localizing drug release

Cited by 21 publications

References 59 publications

Cellulose Nanocrystals (CNCs) and Its Modified Form from Durian Rind as Dexamethasone Carrier

Cellulose Nanocrystals (CNCs) and Its Modified Form from Durian Rind as Dexamethasone Carrier

Fabrication and Investigation of Oxidized-β-Cyclodextrin Nanoparticle as a Novel Class pH Responsive Drug Delivery Vehicle

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

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