2022
DOI: 10.3390/ijms23179587
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Characterization of Philadelphia-like Pre-B Acute Lymphoblastic Leukemia: Experiences in Mexican Pediatric Patients

Abstract: Ph-like subtypes with CRLF2 abnormalities are frequent among Hispano–Latino children with pre-B ALL. Therefore, there is solid ground to suggest that this subtype is frequent in Mexican patients. The genomic complexity of Ph-like subtype constitutes a challenge for diagnosis, as it requires diverse genomic methodologies that are not widely available in diagnostic centers in Mexico. Here, we propose a diagnostic strategy for Ph-like ALL in accordance with our local capacity. Pre-B ALL patients without recurrent… Show more

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Cited by 9 publications
(7 citation statements)
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“…25,27,28 CRLF2 rearrangements were found to be prevalence in Hispanic or Latino ethnics with high incidence up to 49.5% in Mexico population. 29 In our study of large Chinese cohort, the incidence of P2RY8-CRLF2 and IgH-CRLF2 in non-DS BCP-ALL patients was 3.33% and 0.65% respectively, which was similar to those reported by UK Leukemia and St. Jude Children's Hospital studies in unselected cohorts. 8,9 Due to various techniques used to detect CRLF2 expression and different method to define the cut-off value of CRLF2 over-expression, the frequencies of CRLF2 over-expression reported in the literatures were discrepant, ranged from 4.7% to 19%.…”
Section: Discussionsupporting
confidence: 88%
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“…25,27,28 CRLF2 rearrangements were found to be prevalence in Hispanic or Latino ethnics with high incidence up to 49.5% in Mexico population. 29 In our study of large Chinese cohort, the incidence of P2RY8-CRLF2 and IgH-CRLF2 in non-DS BCP-ALL patients was 3.33% and 0.65% respectively, which was similar to those reported by UK Leukemia and St. Jude Children's Hospital studies in unselected cohorts. 8,9 Due to various techniques used to detect CRLF2 expression and different method to define the cut-off value of CRLF2 over-expression, the frequencies of CRLF2 over-expression reported in the literatures were discrepant, ranged from 4.7% to 19%.…”
Section: Discussionsupporting
confidence: 88%
“…Over the past decades, CRLF2 alterations, including P2RY8‐CRLF2 , IgH‐CRLF2 , and CRLF2 overexpression was discovered maybe a hallmark of genetic subgroups of childhood BCP‐ALL with high risk of treatment failure 25,27,28 . CRLF2 rearrangements were found to be prevalence in Hispanic or Latino ethnics with high incidence up to 49.5% in Mexico population 29 . In our study of large Chinese cohort, the incidence of P2RY8‐CRLF2 and IgH‐CRLF2 in non‐DS BCP‐ALL patients was 3.33% and 0.65% respectively, which was similar to those reported by UK Leukemia and St. Jude Children's Hospital studies in unselected cohorts 8,9 .…”
Section: Discussionsupporting
confidence: 88%
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“…The most relevant differences in Mexican patients are: the lower incidence of t ( 12 , 21 )( ETV6::RUNX1 ), similar to Hispanics ( 22 , 26 ). The t ( 1 , 19 )( TCF3::PBX1 ) is slightly more frequent in Mexicans than in Hispanics and non-Hispanics ( 22 , 27 ); abnormalities in CRLF2 are particularly frequent in Mexicans, with a similar incidence of IGH::CRLF2 compared to Hispanics, and P2RY8::CRLF2 is present with a higher frequency, all patients with these rearrangements presented CRLF2 overexpression ( 28 30 ); the iAMP21 is also frequent (10.1% in B-Others) ( 26 , 29 ). This means that in Mexicans, ETV6-RUNX1 , associated with standard prognosis, is reduced, and rearrangements of CRLF2 and iAMP21 , which confer high risk, are widely represented among Mexican patients.…”
Section: Epidemiological Considerations In Pediatric Allmentioning
confidence: 99%