Characterization of photoacoustic tomography system with dual illumination

Fukutani, Keiko; Someda, Yasuhiro; Taku, Masakazu; Asao, Yasufumi; Kobayashi, S; Yagi, T.; Yamakawa, Makoto; Shiina, Tsuyoshi; Sugie, Tomoharu; Toi, Masakazu

doi:10.1117/12.873690

Cited by 17 publications

(14 citation statements)

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“…208,210 The Canon prototype presented a configuration similar to that of the Twente mammograph with respect to patient position and breast compression geometry. 211 The illumination system was different and relied on two sources to provide forward and backward illumination with respect to the 345 element array transducer. The forward and backward laser pulses could be applied simultaneously to maximize optical fluence in the region of interest or alternately to evaluate forward and backward images separately.…”

Section: Photoacoustic Mammographymentioning

confidence: 99%

Review of optical breast imaging and spectroscopy

et al. 2016

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Diffuse optical imaging and spectroscopy of the female breast is an area of active research. We review the present status of this field and discuss the broad range of methodologies and applications. Starting with a brief overview on breast physiology, the remodeling of vasculature and extracellular matrix caused by solid tumors is highlighted that is relevant for contrast in optical imaging. Then, the various instrumental techniques and the related methods of data analysis and image generation are described and compared including multimodality instrumentation, fluorescence mammography, broadband spectroscopy, and diffuse correlation spectroscopy. We review the clinical results on functional properties of malignant and benign breast lesions compared to host tissue and discuss the various methods to improve contrast between healthy and diseased tissue, such as enhanced spectroscopic information, dynamic variations of functional properties, pharmacokinetics of extrinsic contrast agents, including the enhanced permeability and retention effect. We discuss research on monitoring neoadjuvant chemotherapy and on breast cancer risk assessment as potential clinical applications of optical breast imaging and spectroscopy. Moreover, we consider new experimental approaches, such as photoacoustic imaging and long-wavelength tissue spectroscopy.

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Section: Photoacoustic Mammographymentioning

confidence: 99%

Review of optical breast imaging and spectroscopy

et al. 2016

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“…A prototype machine of a dual illuminated mode photoacoustic tomography system (Canon Inc., Tokyo, Japan) was used [24,25]. Figure 1 shows a photograph of the machine and a schematic description of the measurement.…”

Section: Instrumentsmentioning

confidence: 99%

Photoacoustic mammography: initial clinical results

et al. 2012

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“…The technique has been considered for breast cancer imaging since the late 1990s (23)(24)(25), using different implementations and imaging geometry designs. One design trend has been the use of rigid imaging chambers to contain the target tissue and position the optical illumination and ultrasound components at predetermined positions in relation to the object scanned (23,24,(26)(27)(28)(29)(30)(31). Typically, the patient lies in the prone position on a bed with the rigid imaging chamber.…”

Section: Introductionmentioning

confidence: 99%

“…Alternatively, handheld optoacoustic imaging has been considered for breast cancer imaging, using a linear ultrasound array retrofitted with an illumination source for optoacoustic signal generation (32). Notably, optoacoustic imaging of the breast has used at most two wavelengths, which affords limited information on the spectral content of the breast tissues (28,32,33). While rigid imaging chambers may allow three-dimensional data collection and reconstruction, handheld scanners are more versatile in their use and can operate similarly or simultaneously with US, also applied in handheld mode (32).…”

Section: Introductionmentioning

confidence: 99%

Multispectral Optoacoustic Tomography (MSOT) of Human Breast Cancer

Diot

Metz

Noske

et al. 2017

Clinical Cancer Research

226

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In a pilot study, we introduce fast handheld multispectral optoacoustic tomography (MSOT) of the breast at 28 wavelengths, aiming to identify high-resolution optoacoustic (photoacoustic) patterns of breast cancer and noncancerous breast tissue. We imaged 10 female patients ages 48-81 years with malignant nonspecific breast cancer or invasive lobular carcinoma. Three healthy volunteers ages 31-36 years were also imaged. Fast-MSOT was based on unique single-frame-per-pulse (SFPP) image acquisition employed to improve the accuracy of spectral differentiation over using a small number of wavelengths. Breast tissue was illuminated at the 700-970 nm spectral range over 0.56 seconds total scan time. MSOT data were guided by ultrasonography and X-ray mammography or MRI. The extended spectral range allowed the computation of oxygenated hemoglobin (HBO), deoxygenated hemoglobin (HB), total blood volume (TBV), lipid, and water contributions, allowing first insights into high-resolution breast tissue MSOT cancer patterns. TBV and Hb/HBO images resolved marked differences between cancer and control tissue, manifested as a vessel-rich tumor periphery with highly heterogeneous spatial appearance compared with healthy tissue. We observe significant TBV variations between different tumors and between tumors over healthy tissues. Water and fat lipid layers appear disrupted in cancer versus healthy tissue; however, offer weaker contrast compared with TBV images. In contrast to optical methods, MSOT resolves physiologic cancer features with high resolution and revealed patterns not offered by other radiologic modalities. The new features relate to personalized and precision medicine potential. .

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Characterization of photoacoustic tomography system with dual illumination

Cited by 17 publications

References 0 publications

Review of optical breast imaging and spectroscopy

Review of optical breast imaging and spectroscopy

Photoacoustic mammography: initial clinical results

Multispectral Optoacoustic Tomography (MSOT) of Human Breast Cancer

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