Characterization of polymorph transformations that decrease the stability of tablets containing the WHO essential drug mebendazole

Vibrational spectroscopy used in polymorphic analysis

“…To achieve the transition and to obtain the desired crystal form, water activity needed to be controlled [20]. Excipients from the pharmaceutical formulations play an important role in bioavailability, so they were studied too [21].…”

Polymorphism and Solvatomorphism 2010

“…144 Metastable form-C is generally preferred clinically owing to its favorable bioavailability and toxicity properties, but it has been reported that this polymorphic form can convert to the thermodynamically stable, least soluble, form-A under conditions of increased temperature and relative humidity. An accelerated stability study of form-C enabled a conclusion that the Johnson-Mehl-Avrami-Erofeyev-Kolmogorov model could adequately describe the phase transformation kinetics into form-A.…”

Hydrogen bonding motifs, spectral characterization, theoretical computations and anticancer studies on chloride salt of 6-mercaptopurine: An assembly of corrugated lamina shows enhanced solubility

“…In which, the formation of its salts or co-crystals has attracted the field of crystal engineering because of the change in properties of a drug using a generally regarded as safe [4] coformer, especially to get advantageous solubility, bioavailability, stability and good tablet processing qualities [5][6][7][8]. Almost 40% of the APIs in the market today face a major problem of poor solubility [9].…”