2022
DOI: 10.1101/2022.06.21.496989
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Characterization of proteome-size scaling by integrative omics reveals mechanisms of proliferation control in cancer

Abstract: Almost all living cells maintain size uniformity through successive divisions. Proteins that sub- or super-scale with size act as rheostats which regulate cell progression. A comprehensive atlas of these proteins is lacking; particularly in cancer cells where both mitogen and growth signalling are dysregulated.Utilising a multi-omic strategy, that integrates quantitative single cell imaging, phosphoproteomic and transcriptomic datasets, we leverage the inherent size heterogeneity of melanoma cells to investiga… Show more

Help me understand this report
View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 75 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?