Characterization of PVA-IDA Hydrogel Crosslinked with 1.25%, 2.5% and 5% Glutaraldehyde

Thompson, Audie; Nguyen, Danny; Nave, Felecia

doi:10.5176/2339-5060_1.1.1

Cited by 4 publications

(7 citation statements)

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“…The spectra obtained for PVA and PVA/GLUT are in agreement with previous works, which discuss that IR peaks at 3300, 2930, 1731, 1141, and 1091 cm −1 are related to hydroxyl and acetate groups, typical for the PVA and GLUT …”

Section: Resultsmentioning

confidence: 97%

“…Hydroxyls of the PVA react with GLUT to form acetals, and therefore a cross‐linked material becomes less capable of hydrogen bonding with water molecules. During the intermolecular cross‐linking caused by the acetylation reaction, the hydroxyl groups of PVA are consumed resulting in a material with a decreased degree of swelling . In addition, less water can be absorbed after the cross‐linking because the new structure has smaller intermolecular spaces …”

Section: Resultsmentioning

confidence: 99%

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Characterization of PVA/glutaraldehyde hydrogels obtained using Central Composite Rotatable Design (CCRD)

et al. 2017

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Hydrogels are made from natural or synthetic polymers and, currently, they have many biomedical applications. In this work, the conditions for obtaining a hydrogel with similar physicochemical characteristics to the vitreous humor were defined using polyvinyl alcohol (PVA) and glutaraldehyde (GLUT) as cross-linker. The concentration of PVA and GLUT were modified, and their effect was analyzed in terms of the refractive index, density, and dynamic viscosity. The hydrogel which was obtained using 3.98% (w/V) of PVA, 3.13 mL (1.57 g) of GLUT in 100 mL, and the initial pH of 7.2 showed similar characteristics to the vitreous humor (density = 1.0174 ± 0.0050 g mL , dynamic viscosity = 3.7425 ± 0.1800 mPa s and refractive index = 1.3410 ± 0.0010). The hydrogels were further investigated by rheological measurements, infrared spectroscopy, differential scanning calorimetry, X-ray diffraction and determination of swelling degree. The reticulation with GLUT promoted an increase in viscosity and glass transition temperature. On the other hand, it stimulated a decrease in the swelling degree, crystallinity, melting temperature, and intensity of the band related to the -OH bond, compared with the PVA without reticulation. The reticulated hydrogel displayed Newtonian behavior and a higher apparent viscosity than the PVA. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1558-1566, 2018.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Characterization of PVA/glutaraldehyde hydrogels obtained using Central Composite Rotatable Design (CCRD)

et al. 2017

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“…The PWF of PVA-5 (2.61 ± 0.39 L/m 2 ·h) displayed an approximate 5% decrease as compared to PVA-2.5′s PWF measurement (2.74 ± 0.74 L/m 2 ·h). Increasing the concentration of GA increases the rate of reaction, which leads to a decline in chain mobility and reactivity [ 27 , 28 ]. This increase in GA concentration, in turn, increases the density of cross-links in the PVA structure resulting in smaller pores on the surface as confirmed by ESC.…”

Section: Resultsmentioning

confidence: 99%

“…CA’s surface has been chemically reacted and modified with numerous high-performance surface modifiers to increase its antifouling capabilities, and PVA has attracted interest due to the ease of its surface modification. In order to decrease the swelling of the polymeric membrane in water, a chemical solution such as glutaraldehyde (GA) is employed to cross-link the PVA polymer [ 20 , 27 ]. GA is widely used in cross-linking PVA since the aldehyde group of GA forms acetal linkages with the hydroxyl groups of PVA and enhances the potential for covalently linking the PVA to the CA [ 19 , 20 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

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Development and Characterization of Membranes with PVA Containing Silver Particles: A Study of the Addition and Stability

et al. 2020

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Developing technologies for the reduction of biofouling and enhancement of membrane functionality and durability are challenging but critical for the advancement of water purification processes. Silver (Ag) is often used in the process of purification due to its anti-fouling properties; however, the leaching of this metal from a filtration membrane significantly reduces its effectiveness. Our study was designed to integrate the positive characteristics of poly vinyl alcohol (PVA) with the controlled incorporation of nano-scale silver ions across the membrane. This approach was designed with three goals in mind: (1) to improve antifouling activity; (2) to prevent leaching of the metal; and (3) to extend the durability of the functionalized membrane. The fabrication method we used was a modified version of manual coating in combination with sufficient pressure to ensure impregnation and proper blending of PVA with cellulose acetate. We then used the spin coater to enhance the cross-linking reaction, which improved membrane durability. Our results indicate that PVA acts as a reducing agent of Ag+ to Ag0 using X-ray photoelectron spectroscopy analysis and demonstrate that the metal retention was increased by more than 90% using PVA in combination with ultraviolet-photo-irradiated Ag+ reduced to Ag0. The Ag+ ions have sp hybrid orbitals, which accept lone pairs of electrons from a hydroxyl oxygen atom, and the covalent binding of silver to the hydroxyl groups of PVA enhanced retention. In fact, membranes with reduced Ag displayed a more effective attachment of Ag and a more efficient eradication of E. coli growth. Compared to pristine membranes, bovine serum albumin (BSA) flux increased by 8% after the initial addition of Ag and by 17% following ultraviolet irradiation and reduction of Ag, whereas BSA rejection increased by 10% and 11%, respectively. The implementation of this hybrid method for modifying commercial membranes could lead to significant savings due to increased metal retention and membrane effectiveness. These enhancements would ultimately increase the membrane’s longevity and reduce the cost/benefit ratio.

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Film Dressings Based on Hydrogels: Simultaneous and Sustained-Release of Bioactive Compounds with Wound Healing Properties

et al. 2019

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This research proposes the rational modeling, synthesis and evaluation of film dressing hydrogels based on polyvinyl alcohol crosslinked with 20 different kinds of dicarboxylic acids. These formulations would allow the sustained release of simultaneous bioactive compounds including allantoin, resveratrol, dexpanthenol and caffeic acid as a multi-target therapy in wound healing. Interaction energy calculations and molecular dynamics simulation studies allowed evaluating the intermolecular affinity of the above bioactive compounds by hydrogels crosslinked with the different dicarboxylic acids. According to the computational results, the hydrogels crosslinked with succinic, aspartic, maleic and malic acids were selected as the best candidates to be synthesized and evaluated experimentally. These four crosslinked hydrogels were prepared and characterized by FTIR, mechanical properties, SEM and equilibrium swelling ratio. The sustained release of the bioactive compounds from the film dressing was investigated in vitro and in vivo. The in vitro results indicate a good release profile for all four analyzed bioactive compounds. More importantly, in vivo experiments suggest that prepared formulations could considerably accelerate the healing rate of artificial wounds in rats. The histological studies show that these formulations help to successfully reconstruct and thicken epidermis during 14 days of wound healing. Moreover, the four film dressings developed and exhibited excellent biocompatibility. In conclusion, the novel film dressings based on hydrogels rationally designed with combinatorial and sustained release therapy could have significant promise as dressing materials for skin wound healing.

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Characterization of PVA-IDA Hydrogel Crosslinked with 1.25%, 2.5% and 5% Glutaraldehyde

Cited by 4 publications

References 0 publications

Characterization of PVA/glutaraldehyde hydrogels obtained using Central Composite Rotatable Design (CCRD)

Characterization of PVA/glutaraldehyde hydrogels obtained using Central Composite Rotatable Design (CCRD)

Development and Characterization of Membranes with PVA Containing Silver Particles: A Study of the Addition and Stability

Film Dressings Based on Hydrogels: Simultaneous and Sustained-Release of Bioactive Compounds with Wound Healing Properties

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