Characterization of Rabbit Corneas Subjected to Stromal Stiffening by the Açaí Extract (<i>Euterpe oleracea</i>)

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

“…The elastic modulus was 10.5 times higher in corneas treated with 4% açaí extract for 2h than in those in the control group [7].…”

Section: Introductionmentioning

confidence: 74%

Comparison of morphological changes of corneal collagen fibers treated with collagen crosslinking agents using second harmonic generation images

Zeitoune

Bersanetti

Schor

et al. 2020

International Journal of Biological Macromolecules

Self Cite

View full text Add to dashboard Cite

show abstract

“…Slusarewicz et al [28] comparing the efficiency of seven compounds in collagen crosslinking observed that the PA were very efficient and reacted rapidly with the tissue. In addition, Bersanetti et al [29] showed that the ac ¸aı ´extract is efficient to promote an increase in the denaturation temperature and enthalpy of rabbit corneas.…”

Section: Resultsmentioning

confidence: 99%

DSC characterization of rabbit corneas treated with Stryphnodendron adstringens (Mart.) Coville extracts

Cruz

Moraes

Nogueira

et al. 2017

J Therm Anal Calorim

View full text Add to dashboard Cite

Keratoconus is an eye ectasia that affects the cornea causing distortion of vision. Corneal crosslinking promoted by riboflavin photo-stimulated at 365 nm is a treatment used successfully to block the keratoconus progression. In this study, we characterize rabbit corneas subjected to enhanced crosslinking using different vegetable extracts prepared from Stryphnodendron adstringens (Mart.) Coville bark by differential scanning calorimetry. The extracts tested in this study were: aqueous, ketonic, ethanolic, ethyl acetate and hydroalcoholic, which revealed high levels of polyphenols, such as proanthocyanidins. The corneas, obtained from the slaughter rabbits, were divided into groups: control (consisting of untreated corneal samples) and S. adstringens, where the samples were subjected to 4% vegetable extracts for 2 h. The DSC profiles of the corneas were obtained in nitrogen atmosphere. The results showed that temperature and enthalpy of denaturation of the corneal samples treated with S. adstringens were higher than the control group. The control group presents temperature and enthalpy values of 59.8 ± 1.1 °C and 24.6 ± 2.7 J g -1 , respectively. After crosslinking with ketone extract, the values were 90.1 ± 1.1 °C and 39.9 ± 2.7 J g -1 . These results show that S. adstringens is efficient to increment the crosslinking level of the corneas.

show abstract

“…Various photoactivated cross-linkers other than riboflavin include rose bengal, Eosin Y, and WST-D, all of which are excited by different spectra of light. 81 Among the previously reported chemical cross-linkers genipin, 82 glyceraldehyde, 83 glutaraldhyde, 84 Açaí Extract, 85 formaldehyde releasers, 86 decoron, 87 and nitroalcohols 88 have been explored for use in corneal or scleral cross-linking. These agents do not require exposure to irradiance to be activated, but none of them has been translated into clinical practice.…”

Section: Advances In Treatmentmentioning

confidence: 99%

Advances in the diagnosis and treatment of keratoconus

2021

View full text Add to dashboard Cite

Keratoconus had traditionally been considered a rare disease at a time when the imaging technology was inept in detecting subtle manifestations, resulting in more severe disease at presentation. The increased demand for refractive surgery in recent years also made it essential to more effectively detect keratoconus before attempting any ablative procedure. Consequently, the armamentarium of tools that can be used to diagnose and treat keratoconus has significantly expanded. The advances in imaging technology have allowed clinicians and researchers alike to visualize the cornea layer by layer looking for any early changes that might be indicative of keratoconus. In addition to the conventional geometrical evaluation, efforts are also underway to enable spatially resolved corneal biomechanical evaluation. Artificial intelligence has been exploited in a multitude of ways to enhance diagnostic efficiency and to guide treatment. As for treatment, corneal cross-linking treatment remains the mainstay preventive approach, yet the current main focus of research is on increasing oxygen availability and developing new strategies to improve riboflavin permeability during the procedure. Some new combined protocols are being proposed to simultaneously halt keratoconus progression and correct refractive error. Bowman layer transplantation and additive keratoplasty are newly emerging alternatives to conventional keratoplasty techniques that are used in keratoconus surgery. Advances in tissue engineering and regenerative therapy might bring new perspectives for treatment at the cellular level and hence obviate the need for invasive surgeries. In this review, we describe the advances in the diagnosis and treatment of keratoconus primarily focusing on newly emerging approaches and strategies.

show abstract

Characterization of Rabbit Corneas Subjected to Stromal Stiffening by the Açaí Extract (Euterpe oleracea)

Abstract: The açaí extract was effective in promoting CXL in rabbit corneas as characterized by the different techniques.

Cited by 10 publications

References 36 publications

Comparison of morphological changes of corneal collagen fibers treated with collagen crosslinking agents using second harmonic generation images

Comparison of morphological changes of corneal collagen fibers treated with collagen crosslinking agents using second harmonic generation images

DSC characterization of rabbit corneas treated with Stryphnodendron adstringens (Mart.) Coville extracts

Advances in the diagnosis and treatment of keratoconus

Contact Info

Product

Resources

About