Characterization of recent Getah virus isolates from South Korea

Hj, Seo; Hc, Kim; Ta, Klein; Jy, Park; Cho, Yun Sang; Cho, I-S; Sg, Kyung; Jy, Yeh

doi:10.4149/av_2012_03_265

Cited by 13 publications

(9 citation statements)

References 3 publications

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“…It was first isolated from Culex gelidus mosquitoes from Malaysia in 1955. Subsequently, GETV has been isolated in various countries such as Japan, the Philippines, the Republic of Korea, India, and China (Brown and Timoney 1998 ; Nemoto et al 2016 ; Seo et al 2012 ; Zhai et al 2008a ). Recent isolates of GETV in Russia, Mongolia, and China indicate a change in the world distribution in terms of re-emerging GETV (Zhai et al 2008a ).…”

Section: Mosquito-borne Viruses Pathogenic To Humans or Animalsmentioning

confidence: 99%

Mosquito-Associated Viruses in China

et al. 2018

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Mosquitoes are classified into approximately 3500 species and further grouped into 41 genera. Epidemiologically, they are considered to be among the most important disease vectors in the world and they can harbor a wide variety of viruses. Several mosquito viruses are considered to be of significant medical importance and can cause serious public health issues throughout the world. Such viruses are Japanese encephalitis virus (JEV), dengue virus (DENV), chikungunya virus (CHIKV), and Zika virus (ZIKV). Others are the newly recognized mosquito viruses such as Banna virus (BAV) and Yunnan orbivirus (YNOV) with unclear medical significance. The remaining mosquito viruses are those that naturally infect mosquitoes but do not appear to infect humans or other vertebrates. With the continuous development and improvement of mosquito and mosquito-associated virus surveillance systems in China, many novel mosquito-associated viruses have been discovered in recent years. This review aims to systematically outline the history, characteristics, distribution, and/or current epidemic status of mosquito-associated viruses in China.

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Section: Mosquito-borne Viruses Pathogenic To Humans or Animalsmentioning

confidence: 99%

Mosquito-Associated Viruses in China

et al. 2018

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“…GETV is an OW alphavirus, which typically cause rheumatic disease and are also known as arthritogenic alphaviruses. GETV was first isolated in Malaysia in 1955 from a Culex mosquito and then spread to Japan, China, Korea, and Australia [6][7][8][9][10]. As a mosquito-borne virus, GETV has an extensive host range, which includes pig, fox, cattle, horse, and human [9,[11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Structural Insights into Alphavirus Assembly Revealed by the Cryo-EM Structure of Getah Virus

Wang

Sun

Cui

et al. 2022

Viruses

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Getah virus (GETV) is a member of the alphavirus genus, and it infects a variety of animal species, including horses, pigs, cattle, and foxes. Human infection with this virus has also been reported. The structure of GETV has not yet been determined. In this study, we report the cryo-EM structure of GETV at a resolution of 3.5 Å. This structure reveals conformational polymorphism of the envelope glycoproteins E1 and E2 at icosahedral 3-fold and quasi-3-fold axes, which is believed to be a necessary organization in forming a curvature surface of virions. In our density map, three extra densities are identified, one of which is believed a “pocket factor”; the other two are located by domain D of E2, and they may maintain the stability of E1/E2 heterodimers. We also identify three N-glycosylations at E1 N141, E2 N200, and E2 N262, which might be associated with receptor binding and membrane fusion. The resolving of the structure of GETV provides new insights into the structure and assembly of alphaviruses and lays a basis for studying the differences of biology and pathogenicity between arthritogenic and encephalitic alphaviruses.

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“…Our sero-prevalence data show that the overall seropositivity rate for GETV in racehorses was moderately low (12.4%); in addition, the regional sero-prevalence against GETV ranged from 22.3% It is known that A. vexans nipponii, which transmits both GETV and Japanese encephalitis virus (JEV), is distributed widely in Korea; it was first found in Gyeongnam province during the early summer season (27,28). According to a recently paper, Aedes vexans nipponii collected in June 2010 was positive for GETV (10). According to our serosurveillance data, Gyeongnam province showed the highest seropositivity rate for GETV (22.3%) among the other prov- inces.…”

Section: Disccusionmentioning

confidence: 96%

“…GETV was isolated in Malaysia in 1955 from Culex gelidus mosquitoes (7), and has since been isolated from a variety of mosquitoes, including Culex, Aedes, and Armigeres in Japan, China, Korea, and Australia (8,9,10,11). GETV infections in horses have been reported in Japan and India (12,13).…”

Section: Chikungunya Mayaro O'nyong Nyong Ross River Semlikimentioning

confidence: 99%

Sero-surveillance of Getah Virus among Thoroughbred Horses in Korea

Yang

Kim

et al. 2015

J Bacteriol Virol

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Getah virus (GETV), which is transmitted by mosquitoes, causes lower limb edema and stiffness in horses. In this study, we investigated the sero-surveillance of GETV among Thoroughbred racehorses in Korea during 2013 and 2014. A total of 1,182 equine serum samples collected from Thoroughbred racehorses in four provinces (Gyeongnam, Gyeonggi, Jeonbuk and Jeju provinces) were analyzed using virus neutralization (VN) tests. An antibody titer of ≥ 1:2 was considered positive. Overall, the seropositivity rate for GETV was found to be 12.4% (146/1,182) among the racehorses; the annual seropositivity rates were 12.4% and 12.2% in 2013 and 2014, respectively. The seropositivity rates in April and September in 2013 turned out to be 8.6% and 15.2%, respectively. The regional distribution of seropositivity ranged from 5.0% to 22.3% in 2013 and from 0.0% to 15.0% in 2014, respectively. Gyeongnam province had the highest seropositivity rate than other provinces. By analyzing the distribution of VN titers according to horse age, we found that the highest GETV seropositivity rate was in horses over 6 years of age (22.4% and 28.1%, 2013 and 2014, respectively), and that the incidence of GETV was higher in geldings (17.6% and 18.6%, 2013 and 2014, respectively) than in males and females. These results indicate that Thoroughbred horses raised in Korea were bitten by mosquitoes harboring GETV.

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Characterization of recent Getah virus isolates from South Korea

Cited by 13 publications

References 3 publications

Mosquito-Associated Viruses in China

Mosquito-Associated Viruses in China

Structural Insights into Alphavirus Assembly Revealed by the Cryo-EM Structure of Getah Virus

Sero-surveillance of Getah Virus among Thoroughbred Horses in Korea

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