Characterization of regulatory T cell responses to defined immunodominant T cell epitopes of the Plasmodium falciparum antigen Pf155/RESA

Troye‐Blomberg, Marita; Sjöberg, Katarina; Olerup, Olle; Riley, Eleanor M.; Kabilan, L; Perlmann, Hedvig; Marbiah, Nuahn T.; Perlmann, Peter

doi:10.1016/0165-2478(90)90103-w

Cited by 16 publications

(6 citation statements)

References 28 publications

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“…In recent studies with several antigens from both blood and gametocyte stages of the parasites, it was suggested that bias toward a particular responder type may reflect the type of exposure encountered during childhood, akin to the phenomenon of clonal imprinting or "original antigenic sin" (26,39). Another possibility is that host genetic factors are important for responder status as is the case for the response to Pf155/RESA (41).…”

Section: Discussionmentioning

confidence: 99%

Levels of Antibody to Conserved Parts ofPlasmodium falciparumMerozoite Surface Protein 1 in Ghanaian Children Are Not Associated with Protection from Clinical Malaria

et al. 1999

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The 19-kDa conserved C-terminal part of the Plasmodium falciparum merozoite surface protein 1 (PfMSP1 19 ) is a malaria vaccine candidate antigen, and human antibody responses to PfMSP1 19 have been associated with protection against clinical malaria. In this longitudinal study carried out in an area of stable but seasonal malaria transmission with an estimated parasite inoculation of about 20 infective bites/year, we monitored 266 3to 15-year-old Ghanaian children clinically and parasitologically over a period of 18 months. Blood samples were collected at the beginning of the study before the major malaria season in April and after the season in November. Using enzyme-linked immunosorbent assay, we measured antibody responses to recombinant gluthathione S-transferase-PfMSP1 19 fusion proteins corresponding to the Wellcome and MAD20 allelic variants in these samples. Prevalence of antibodies recognizing the Wellcome 19 construct containing both epidermal growth factor (EGF)-like motifs in Wellcome type PfMSP1 19 was about 30%. Prevalence of antibodies to constructs containing only the first EGF domain from either Wellcome or MAD20 type PfMSP1 19 was about 15%, whereas antibodies recognizing a construct containing only the second EGF domain of MAD20 type PfMSP1 19 was found in only about 4% of the donors. Neither the prevalence nor the levels of any of the antibody specificities varied significantly with season, age, or sex. Significantly, and in contrast to previous reports from other parts of West Africa, we found no evidence of an association between antibody responses to PfMSP1 19 and clinical protection against malaria.

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Section: Discussionmentioning

confidence: 99%

Levels of Antibody to Conserved Parts ofPlasmodium falciparumMerozoite Surface Protein 1 in Ghanaian Children Are Not Associated with Protection from Clinical Malaria

et al. 1999

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“…T-cell responses to Pfl55 / RESA antigen include proliferation and lymphokine production and T-dependent B-cell production of anti-Pfl55/RESA antibodies (38). An interesting finding is the apparent dissociation between different T-cell response types to Pfl55/RESA (38), suggesting functionally distinct T-cell subsets, similar to the TH1 and TH2 type T cells described in mice (88,91).…”

Section: Asexual Blood Stage Antigensmentioning

confidence: 95%

T‐cell responses in malaria

Hviid

Jakobsen

Abu-Zeid

et al. 1992

APMIS

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Malaria is caused by infection with protozoan parasites of the genus Plasmodium. It remains one of the most severe health problems in tropical regions of the world, and the rapid spread of resistance to drugs and insecticides has stimulated intensive research aimed at the development of a malaria vaccine. Despite this, no efficient operative vaccine is currently available. A large amount of information on T-cell responses to malaria antigens has been accumulated, concerning antigens derived from all stages of the parasite life cycle. The present review summarizes some of that information, and discusses factors affecting the responses of T cells to malaria antigens.

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“…In in vitro cultures it has also been shown that production of IL-4 by PBMC stimulated with defined antigenic peptides from the RESA/Pf 155 P . falciparum was correlated with the in vitro production of antibodies to the same peptide (Troye-Blomberg et al 1990b, Riley, Olerup & Troye-Blomberg, 1991.…”

Section: Di5cussionmentioning

confidence: 97%

In vitro lymphoproliferative responses to malaria antigens: a prospective study of residents of a holoendemic area with perennial malaria transmission

Mshana

Boulandi

Mayombo

et al. 1993

Parasite Immunology

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A longitudinal, prospective study to examine the relationship between the outcome of infection with Plasmodium falciparum parasites and in vitro T-cell proliferative responses to a P. falciparum schizont extract (PfSE) was conducted in a village in south-eastern Gabon, an area where malaria is holoendemic and transmission is intense and perennial. The donor's age was found to have a strong independent influence on all malariometric indices. At the community level, the in vitro lymphoproliferative response to PfSE was bimodal with 30% of the villagers studied showing persistently low responses. The frequency of low or high responders within the study population did not show any consistent relationship with the community parasite rates or the number of either patent parasitaemic episodes or clinical malarial attacks per individual. At the individual donor level, the response was negatively correlated with P. falciparum parasite density in those donors who were parasitaemic at the time of sampling. High in vitro lymphoproliferative responses to PfSE were predictive of resistance to clinical malaria. The PfSE-induced in vitro lymphoproliferative response was dependent on antigen presenting cells, CD4+ T-cells and UCHL-1+ cells.

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Characterization of regulatory T cell responses to defined immunodominant T cell epitopes of the Plasmodium falciparum antigen Pf155/RESA

Cited by 16 publications

References 28 publications

Levels of Antibody to Conserved Parts ofPlasmodium falciparumMerozoite Surface Protein 1 in Ghanaian Children Are Not Associated with Protection from Clinical Malaria

Levels of Antibody to Conserved Parts ofPlasmodium falciparumMerozoite Surface Protein 1 in Ghanaian Children Are Not Associated with Protection from Clinical Malaria

T‐cell responses in malaria

In vitro lymphoproliferative responses to malaria antigens: a prospective study of residents of a holoendemic area with perennial malaria transmission

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