Characterization of Riboflavin-modified Dentin Collagen Matrix

Fawzy, A.; Nitisusanta, Lorraine I.; Iqbal, Kulsum; Daood, Umer; Beng, Lu Thong; Neo, Jaclyn L.

doi:10.1177/0022034512459053

Cited by 51 publications

(61 citation statements)

References 26 publications

(38 reference statements)

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“…In contrast to the current results, some previous studies stated that dentin surface preparation with RF/UVA increased the µTBS values immediately and after water storage (9, 30). They attributed this increase in bond strength to the stiffness of dentin collagen matrix (9,30,32), upstanding of collagen fibrils and enhanced resin infiltration following cross-linking (30), decreased activity of MMPs due to increased cross linking of dentin collagen (9,29) and direct cross linking of MMPs (9). The difference between the current results and those of previous studies may be explained as follows:…”

Section: Discussioncontrasting

confidence: 59%

“…Due to the biocompatibility and cross linking of dentin collagen matrix, this technique may be used as a method of dentin surface preparation or as an optimizer of adhesive systems (29). This study aimed to assess the efficacy of riboflavin activated with light (by a light curing unit) for collagen cross linking and optimizing the bond strength of an etch and rinse adhesive system to dentin.…”

Section: Introductionmentioning

confidence: 99%

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The Efficacy of Riboflavin for Collagen Cross-Linking and Optimizing the Bond Strength of an Etch and Rinse Adhesive System to Dentin

Kasraei¹,

Malek²,

Khamverdi³

et al. 2017

Avicenna J Dent Res

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Background and Objectives: Previous studies have shown that increasing collagen resistance to degradation stabilizes the resindentin interface and collagen cross-linkers can prevent the degradation of collagen fibrils as such. This study sought to assess the efficacy of light-activated riboflavin for collagen cross-linking and optimizing the micro tensile bond strength (µTBS) of an etch and rinse adhesive system to dentin. Methods: Occlusal surfaces of 12 sound premolars were ground in order to expose dentin. The teeth were randomly divided into two groups. Adper single bond was applied on etched dentin and light cured in the control group and Composite was then applied. In the test group, all the steps were done in a similar manner to the control group with the difference that after acid etching, 0.1% riboflavin solution was applied on dentin surface and was activated by blue light irradiation for 2 minutes. After thermocycling, the teeth were sectioned in 2 directions in such a way that 14 resin-dentin sticks with 1 mm2 cross-section were prepared in each

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Section: Discussioncontrasting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

The Efficacy of Riboflavin for Collagen Cross-Linking and Optimizing the Bond Strength of an Etch and Rinse Adhesive System to Dentin

Kasraei¹,

Malek²,

Khamverdi³

et al. 2017

Avicenna J Dent Res

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“…The most likely reason for significant improvement in the bulk mechanical properties of non-demineralized dentin is the formation of covalent crosslinks in the dentin collagen matrix, which was detected by Raman analysis. Recently, UVA-RF was found to crosslink the collagen matrix, and to increase the mechanical properties of demineralized dentin (7). In this study, the dentin specimens were etched with 37% phosphoric acid to dissolve the mineral components and expose the collagen matrix to UVA-RF directly.…”

Section: Discussionmentioning

confidence: 99%

“…UVA-activated riboflavin (UVA-RF) has been considered to be a successful treatment strategy for progressive keratoconus because of its consistent stabilizing effect in corneal collagen crosslinking (4). Recently, UVA-RF has been shown to enhance the mechanical properties and mechanical stability of dentin collagen matrix (6,7). However, these studies focused on completely demineralized dentin collagen.…”

Section: Introductionmentioning

confidence: 99%

UVA-activated riboflavin improves the strength of human dentin

Liu

Zhou

Chen

et al. 2015

Journal of Oral Science

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The aim of this study was to evaluate the effects of UVA-activated riboflavin (UVA-RF) on the mechanical properties of non-demineralized human dentin. Dentin specimens obtained from 20 teeth were randomly divided into the following four groups: group 1 (control): no treatment, group 2 (low UVA-RF): specimens were exposed to UVA-RF for 10 min, group 3 (medium UVA-RF): specimens were exposed to UVA-RF for 30 min, and group 4 (high UVA-RF): specimens were exposed to UVA-RF for 60 min. Three-point flexural test and Raman spectroscopic analyses were performed. The mean flexural strengths (MPa) were 129.96, 128.96, 144.21, and 147.54, and the mean elastic modulus (GPa) were 8.59, 8.38, 10.21, and 9.87 for groups 1 to 4, respectively. Raman spectra showed chemical modifications of dental collagen under medium and high UVA-RF treatment. We conclude that medium and high UVA-RF increases the strength of non-demineralized human dentin by collagen crosslinking. (J Oral Sci 57, 229-234, 2015)

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“…36,37 Riboflavin, bağlanma dayanımını arttırır, adeziv ara yüzeyi stabilize eder ve dentin MMPlerini inhibe eder. 36,38 Proantosiyanidin; doğal olarak oluşan polifenolik bileşenidir, tannin olarak da adlandırılır. Antioksidan özelliği olan çapraz bağ ajanıdır ve toksisitesi düşüktür.…”

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Effects of matrix metalloproteinase enzyms on adhesive bonding

Halaçoğlu¹,

Can²

2017

Yeditepe J Dent

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ÖZETMatriks metalloproteinaz enzimleri (MMP), dentin matriksinin içinde bulunan proteolitik enzimlerdir ve dentinin organik matriksini hidrolize etme özellikleri vardır. Rezin-dentin bağlanmasının elde edilmesi için dentine asit uygulanması sonrası dentinin kollajen fibrilleri açığa çıkar. Bu açığa çıkan kollajen fibriller MMP'lerin başlattığı hidrolitik bozulmadan etkilenebilir ve bunun sonucunda bağlanma dayanımında azalma olarak restorasyonların ağız içerisindeki uzun dö-nem performansı negatif etkilenebilir. Bu derlemenin amacı, dentin kaynaklı MMP'lerin dentin matriks bozulmasındaki rolünün anlaşılması ve kollajen bozulmasını inhibe eden MMP inhibitörlerinin dentinin bağlanma dayanımına etkisinin özetlenmesidir. Anahtar Kelimeler: Matriks metalloproteinazlar, dental adezivler, kollajen SUMMARY Matrix metalloproteinase enzymes (MMP) are proteolytic enzymes that found in dentin matrix and they are capable to hydrolyze organic matrix of dentin. Dentin collagen fibrils are exposed after acid etching of dentin in order to achieve resin-dentin bonding. These exposed collagen fibrils might be effected by hydrolytic degradation caused by MMP's resulting reduced bonding strength and long-term performance in oral cavity. The purpose of this review is to understand the role of MMP's in dentin matrix degradation and to summarize the effects of MMP inhibitors that inhibits the collagen degradation to dentin bonding strength. Key words: Matrix metalloproteinases, dental adhesives, collagen GİRİŞ Restoratif diş hekimliği alanında yapılan pek çok çalışma ve yeni geliştirilen materyallere rağmen, dentin-adeziv ara yüzeyi diş restorasyon kompleksindeki en zayıf nokta olma özelliğini korumaktadır. Rezin-dentin bağlanmasının elde edilmesi için dentin yüzeyinin fiziksel ve kimyasal özelliklerini değiştirecek birkaç uygulama yapılması gerekir. Kavite preparasyonu sırasında dentin yüzeyinde oluşan 1-2µm kalınlığında smear tabakası self-etching primer ile modifiye edilir veya %37'lik fosforik asit ile tamamen ortadan kaldırılır.1 Dentinin asitlendiği durumlarda, dentin yüzeyinde-ki tüm mineral komponent ve smear tabakasının altında bulunan 5µm kalınlıkta mineralize dentin çözünür ve böylece altta bulunan tip I kollajen fibril ağı açığa çıkar.2 Kollajen fibriller arasında oluşan boşluğa interfibriler alan adı verilir ve bu boşluk adeziv komonomerleri için difüzyon kanalları oluşturur.3 Adeziv komonomerleri demineralizasyon derinliği boyunca ilerleyerek hibrit tabakasını oluşturur. 4 İdealde hibrit tabakasının uzun yıllar boyunca sağlam kalması beklenir, ancak zamanla hidrolitik çözünmeden dolayı adeziv ara yüzey-de bozulmalar meydana gelebilir.

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Characterization of Riboflavin-modified Dentin Collagen Matrix

Cited by 51 publications

References 26 publications

The Efficacy of Riboflavin for Collagen Cross-Linking and Optimizing the Bond Strength of an Etch and Rinse Adhesive System to Dentin

The Efficacy of Riboflavin for Collagen Cross-Linking and Optimizing the Bond Strength of an Etch and Rinse Adhesive System to Dentin

UVA-activated riboflavin improves the strength of human dentin

Effects of matrix metalloproteinase enzyms on adhesive bonding

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