Characterization of ribonucleotide reductases of emerging pathogens<i>Elizabethkingia anophelis</i>and<i>Elizabethkingia meningoseptica</i>and streptonigrin as their inhibitor: a computational study

Mahfuz, A M U B; Iqbal, Muhammad Nasir; Opazo, Felipe Stambuk; Zubair-Bin-Mahfuj, A. M.

doi:10.1080/07391102.2021.1930166

Cited by 4 publications

(3 citation statements)

References 31 publications

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“… 27 These results indicate that streptonigrin may be a potential inhibitor of these ribonucleotide reductases. 27 …”

Section: Biological Activities Of Streptonigrinmentioning

confidence: 88%

“…According to the results from the most recent study on molecular docking and dynamics simulations, streptonigrin can bind to Elizabethkingia anophelis and Elizabethkingia meningoseptica ribonucleotide reductase alpha subunits with good affinity. 27 These results indicate that streptonigrin may be a potential inhibitor of these ribonucleotide reductases. 27 One of the very early studies showed that the bacteriocidal activity of streptonigrin is similar to that of mitomycin, which also contains an aminoquinone fragment.…”

Section: Antibacterial Activitymentioning

confidence: 88%

“…27 These results indicate that streptonigrin may be a potential inhibitor of these ribonucleotide reductases. 27 One of the very early studies showed that the bacteriocidal activity of streptonigrin is similar to that of mitomycin, which also contains an aminoquinone fragment. 2 Further, a study reported that a modified bacteria foraging algorithm (mbfA) mutant of Bradyrhizobium japonicum defective in iron export is sensitive to short-term exposure to high levels of iron or hydrogen peroxide.…”

Section: Antibacterial Activitymentioning

confidence: 88%

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Chemistry, Biosynthesis and Pharmacology of Streptonigrin: An Old Molecule with Future Prospects for New Drug Design, Development and Therapy

Nasir¹,

Sekar²,

Ravi³

et al. 2023

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Streptonigrin is an aminoquinone alkaloid isolated from Streptomyces flocculus and is gaining attention as a drug molecule owing to its potential antitumor and antibiotic effects. It was previously used as an anticancer drug but has been discontinued because of its toxic effects. However, according to the most recent studies, the toxicity of streptonigrin and its structurally modified derivatives has been reduced while maintaining their potential pharmacological action at lower concentrations. To date, many investigations have been conducted on this molecule and its derivatives to determine the most effective molecule with low toxicity to enable new drug discovery. Therefore, the main objective of this study is to provide a comprehensive review and to discuss the prospects for streptonigrin and its derived compounds, which may boost the molecule as a highly interesting target molecule for new drug design, development and therapy. To complete this review, relevant literature was collected from several scientific databases, including Google Scholar, PubMed, Scopus and ScienceDirect. Following a complete screening, the obtained information is summarized in the present review to provide a good reference and accelerate the development and utilization of streptonigrin and its derivatives as pharmaceuticals.

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“… 27 These results indicate that streptonigrin may be a potential inhibitor of these ribonucleotide reductases. 27 …”

Section: Biological Activities Of Streptonigrinmentioning

confidence: 88%

Section: Antibacterial Activitymentioning

confidence: 88%