“…Also, conventional extractions involve the use of large amounts of solvents, such as hydrocarbons, alcohols and chloro-alkanes, since the majority of phenolic compounds are not soluble in water (Ignat, Volf, & Popa, 2011). In some cases, such as an extraction of grape skin and seed proanthocyanidins, two steps extractions using first acetone/ water followed by methanol/water are usually used ( Curko et al, 2014). In addition, special attention should be paid to the choice of solvent in order to prevent target molecule degradation (Ignat et al, 2011;Revilla, Ryan, & Martín-Ortega, 1998).…”