Characterization of sensitization to furry animal allergen components in an adult population

Suzuki, Shintaro; Nwaru, Bright I.; Ekerljung, Linda; Sjölander, Sigrid; Mincheva, Roxana; Rönmark, Erik P.; Rönmark, Eva; Lundbäck, Bo; Borres, Magnus P.; Lötvall, Jan

doi:10.1111/cea.13355

Cited by 34 publications

(56 citation statements)

References 39 publications

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“…Fel d 1, a secretoglobin, is the major cat allergen . (Table ) Although monosensitization to Fel d 1 is common, individuals sensitized to the cat allergens Fel d 2 (an albumin allergen) and Fel d 4 (a lipocalin allergen) are usually also sensitized to Fel d 1 . Fel d 1 is a sufficiently dominant allergen that IgE sensitization to Fel d 1 is equivalent to cat extract in predicting cat allergy …”

Section: Fel D1 the Major Cat Allergenmentioning

confidence: 99%

“…Allergies to cat affect 7%‐25% of the population and represent a growing public health concern as these rates increase . The prevalence of cat allergy varies between countries, timing of exposure, and allergic predisposition .…”

Section: Cat Allergies: a Common Problem With Consequences For Humansmentioning

confidence: 99%

“…In the West Sweden Asthma Study, the characterization of sensitization to furry animal allergen components was assessed in an adult population . Fel d 1 was the most prevalent cat component in monosensitized individuals, whereas all cat allergens including Fel d 1 were detected in polysensitized individuals.…”

Section: Cat Allergies: a Common Problem With Consequences For Humansmentioning

confidence: 99%

“…2,[5][6][7][8][9]13 (Table 1) Although monosensitization to Fel d 1 is common, individuals sensitized to the cat allergens Fel d 2 (an albumin allergen) and Fel d 4 (a lipocalin allergen) are usually also sensitized to Fel d 1. 3 Fel d 1 is a sufficiently dominant allergen that IgE sensitization to Fel d 1 is equivalent to cat extract in predicting cat allergy. 3,13,14 All cats produce Fel d 1 regardless of breed, age, hair length, sex, housing (indoors vs outdoors), or body weight; there are no allergenfree or hypoallergenic cats.…”

Section: Fel D1 the Ma Jor C At Allerg Enmentioning

confidence: 99%

“…Allergies to cats are the most common mammalian‐origin allergy in humans and affect approximately 1 in 5 adults worldwide . Fel d 1 is the major cat allergen, accounting for up to 96% of human allergic sensitization to cats and 60%‐90% of the overall antigenicity of cats and cat dander …”

Section: Introductionmentioning

confidence: 99%

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Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen

Satyaraj¹,

Wedner

Bousquet

2019

Allergy

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Background Allergies to cats are the most common animal‐origin allergy, and affect approximately 1 in 5 adults worldwide. The prevalence of allergy to furry animals has been increasing, and allergy to cats is a major risk factor for the development of asthma and rhinitis. The diagnosis of cat allergy is now well established. The exact significance of component‐resolved diagnosis in the diagnosis of cat allergy remains to be fully understood. Allergen avoidance is effective but often has a psychologic impact. Allergen immunotherapy is not well demonstrated. There is a need for innovative approaches to better manage cat allergens. Next‐generation care pathways for asthma and rhinitis will define the place of cat allergen avoidance. Methods and Results This manuscript, based on content presented at the European Academy of Allergy and Clinical Immunology Congress 2019, provides information on the prevalence and impact of cat allergies and the molecular biology of Fel d 1, the major cat allergen. Discussion The authors present the scientific basis of a novel care pathway that utilizes anti‐Fel d 1 IgY antibodies to safely and effectively neutralize Fel d 1 after its production by the cat but before human exposure. Conclusion Efficacy of a feline diet with an egg product ingredient containing anti‐Fel d 1 IgY antibodies was demonstrated in vitro, ex vivo, and in vivo, and further validated by a pilot exposure study involving cat‐allergic human participants.

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Section: Fel D1 the Major Cat Allergenmentioning

confidence: 99%

Section: Cat Allergies: a Common Problem With Consequences For Humansmentioning

confidence: 99%

Section: Cat Allergies: a Common Problem With Consequences For Humansmentioning

confidence: 99%

Section: Fel D1 the Ma Jor C At Allerg Enmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen

Satyaraj¹,

Wedner

Bousquet

2019

Allergy

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Complex IgE sensitization patterns in ragweed allergic patients: Implications for diagnosis and specific immunotherapy

Buzan

Zbîrcea

Gattinger

et al. 2022

Clinical & Translational All

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Background Ragweed (Ambrosia artemisiifolia) is one of the most important allergen sources, worldwide, causing severe respiratory allergic reactions in late summer and fall, in sensitized patients. Amb a 1 has been considered as the most important allergen in ragweed but 12 ragweed pollen allergens are known. The aim of our study was to investigate IgE reactivity profiles of ragweed allergic patients and to associate them with clinical symptoms. Methods IgE sensitization profiles from clinically well‐characterized ragweed allergic patients (n = 150) were analyzed using immunoblotted ragweed pollen extract. Immunoblot inhibition experiments were performed with two Amb a 1 isoforms and CCD markers and basophil activation experiments were performed with IgE serum before and after depletion of Amb a 1‐specific IgE. Results By IgE‐immunoblotting 19 different IgE reactivity patterns with and without Amb a 1‐sensitization were found. The majority of patients (>95%) suffered from rhino‐conjunctivitis, around 60% reported asthma‐like symptoms and about 25% had skin reactions. Patients with complex IgE sensitization profiles tended to have more clinical symptoms. Serum with and without Amb a 1‐specific IgE induced basophil activation. Conclusions Ragweed pollen allergic patients exhibit complex IgE reactivity profiles to ragweed allergens including Amb a 1 isoforms and cross‐reactive carbohydrates indicating the importance of Amb a 1 isoforms and additional allergens for diagnosis and allergen‐specific immunotherapy of ragweed allergy.

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Sensitization patterns to cat molecular allergens in subjects with allergic sensitization to cat dander

Özuygur Ermis,

Norouzi,

Borres

et al. 2023

Clinical & Translational All

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BackgroundThe use of molecular allergology has increasingly become common in the diagnosis and management of allergic diseases. However, there is still a lack of data on cat molecular allergens in adults. Therefore, we aimed to uncover the sensitization patterns to cat molecular allergens.MethodsParticipants were recruited from the West Asthma Sweden Study, a population‐based study enriched with asthma subjects aged 16–75 years. Of 1872, 361 individuals were positive for cat dander immunoglobulin E and were further analysed for cat molecular allergens (Fel d 1/2/4/7). Sensitization patterns were classified as monosensitization, polysensitization, and concomitant sensitization, and were related to demographic and clinical measurements.ResultsAmong cat‐sensitized subjects, 84.2% were sensitized to secretoglobin, while 42.4% were sensitized to lipocalins. Nearly half of the subjects were monosensitized to Fel d 1. Polysensitization was observed in 20.2%, and concomitant sensitization to protein families was seen in 7.2%. Asthma prevalence, cat exposure, and rural living were associated with poly‐ and concomitant sensitization to protein families. Concomitant sensitization to single allergens was more common in those with asthma than in those without, while concomitant sensitization to both Fel d 1 and Fel d 4 was the most common pattern in individuals with asthma. Sensitization patterns also differed according to cat ownership and the degree of urbanization.ConclusionSensitization to molecular allergens was observed in 90.9% of cat‐sensitized subjects and showed variations across participants' background characteristics and the presence of asthma. Identification of sensitization patterns to cat allergens might provide better characterization of cat‐allergic subjects.

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Characterization of sensitization to furry animal allergen components in an adult population

Cited by 34 publications

References 39 publications

Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen

Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen

Complex IgE sensitization patterns in ragweed allergic patients: Implications for diagnosis and specific immunotherapy

Sensitization patterns to cat molecular allergens in subjects with allergic sensitization to cat dander

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