Characterization of serum acid phosphatase associated with dengue hemorrhagic fever.

Lam, Kwok‐Wai; Burke, Donald S.; Siemens, M; Cipperly, V; Li, C Y; Yam, Lung T.

doi:10.1093/clinchem/28.11.2296

Cited by 5 publications

(1 citation statement)

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“…Observation has revealed that acid phosphatase in the serum was higher and showed the activity of 5.74 IU/L, which correlates with the results of studies carried out by Yam [5]. The reason for increased activity of acid phosphatase in DF is their release from osteoclast, which is in accordance with the clinical observation of severe bone pain in many patients associated with this disease [6]. Irregular increase in alkaline phosphatase was observed which was also seen by Jagadishkumar et al [7].…”

Section: Discussionsupporting

confidence: 86%

Biochemical Study of Certain Enzymes in Dengue Fever Patients

Jain

Kumar²,

Sogani

2020

Asian J Pharm Clin Res

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Objective: The main objective of the present study is to correlate the effect of certain enzymes in diagnosis of dengue fever (DF) and impact of these elevated/decreased blood levels of enzymes on patients of DF. Methods: The study was carried out on 30 patients suspected to be suffering from DF. Blood sample was collected and tested for various parameters such as protein (albumin), lactate dehydrogenase (LDH), creatinine kinase (CK), C-reactive protein (CRP), acid phosphatase, alkaline phosphatase, serum glutamic oxaloacetic transaminase (SGOT), and serum glutamic pyruvic transaminase (SGPT). Results: Serum enzymes such as LDH and CK were found to be elevated to be a good marker of muscle damage and progression of diseases. CRP as a marker of inflammation was also found to be elevated. Enzymes like acid phosphatase increased abruptly while alkaline phosphatase was irregular. Liver enzymes SGOT and SGPT activity were also enhanced. Conclusion: Increased level of transaminases can be reflective of the formation of various amino acids for the synthesis of new protein and for channeling of glutamate and aspartate along with glycine for the synthesis of purine and pyrimidine nucleotides. Objective: The main objective of the present study is to correlate the effect of certain enzymes in diagnosis of dengue fever (DF) and impact of these elevated/decreased blood levels of enzymes on patients of DF. Methods: The study was carried out on 30 patients suspected to be suffering from DF. Blood sample was collected and tested for various parameters such as protein (albumin), lactate dehydrogenase (LDH), creatinine kinase (CK), C-reactive protein (CRP), acid phosphatase, alkaline phosphatase, serum glutamic oxaloacetic transaminase (SGOT), and serum glutamic pyruvic transaminase (SGPT). Results: Serum enzymes such as LDH and CK were found to be elevated to be a good marker of muscle damage and progression of diseases. CRP as a marker of inflammation was also found to be elevated. Enzymes like acid phosphatase increased abruptly while alkaline phosphatase was irregular. Liver enzymes SGOT and SGPT activity were also enhanced. Conclusion: Increased level of transaminases can be reflective of the formation of various amino acids for the synthesis of new protein and for channeling of glutamate and aspartate along with glycine for the synthesis of purine and pyrimidine nucleotides.

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Section: Discussionsupporting

confidence: 86%