Characterization of Silver Sulfadiazine and Related Compounds

Sandmann, Beverly J.; Nesbitt, Russell U.; Sandmann, Robert A.

doi:10.1002/jps.2600630634

Cited by 20 publications

(3 citation statements)

References 4 publications

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“…SMT-Ag is highly hydrophobic, with water solubility <3 µg/mL, as determined by UV–Vis spectrophotometry, which makes the binding of SMT-Ag to the carrier by adsorption or complexation quite challenging. However, some silver sulfonamides show increased solubility in ammonia [ 41 ]. The solubility of STM-Ag in 0.06% ammonia was nine times higher than that in water, reaching 18 ± 0.2 ug/mL, which may potentially simplify drug loading.…”

Section: Resultsmentioning

confidence: 99%

Silver-Sulfamethazine-Conjugated β-Cyclodextrin/Dextran-Coated Magnetic Nanoparticles for Pathogen Inhibition

Shatan,

Patsula,

Macková

et al. 2024

Nanomaterials

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In the fight against antibiotic resistance, which is rising to dangerously high levels worldwide, new strategies based on antibiotic-conjugated biocompatible polymers bound to magnetic nanoparticles that allow the drug to be manipulated and delivered to a specific target are being proposed. Here, we report the direct surface engineering of nontoxic iron oxide nanoparticles (IONs) using biocompatible dextran (Dex) covalently linked to β-cyclodextrin (β-CD) with the ability to form non-covalent complexes with silver-sulfamethazine (SMT-Ag). To achieve a good interaction of β-CD-modified dextran with the surface of the nanoparticles, it was functionalized with diphosphonic acid (DPA) that provides strong binding to Fe atoms. The synthesized polymers and nanoparticles were characterized by various methods, such as nuclear magnetic resonance (NMR), Fourier transform infrared (FTIR) and ultraviolet–visible (UV–Vis) spectroscopies, transmission electron microscopy (TEM), thermogravimetric analysis (TGA), atomic absorption spectroscopy (AAS), dynamic light scattering (DLS), etc. The resulting magnetic ION@DPA-Dex-β-CD-SMT-Ag nanoparticles were colloidally stable in water and contained 24 μg of antibiotic per mg of the particles. When tested for in vitro antimicrobial activity on Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria and fungi (yeast Candida albicans and mold Aspergillus niger), the particles showed promising potential.

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Section: Resultsmentioning

confidence: 99%

Silver-Sulfamethazine-Conjugated β-Cyclodextrin/Dextran-Coated Magnetic Nanoparticles for Pathogen Inhibition

Shatan,

Patsula,

Macková

et al. 2024

Nanomaterials

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“… 32 In addition, the proven efficacy of AgSD in the treatment of Pseudomonas infection in burns has been documented. 33 In line with our research program in replacing traditional synthetic methods by electrochemical methods 1–7,17 herein, we would like to report an efficient electrochemical method for the synthesis of AgSD microcrystals through oxidation of a silver rod in the presence of sulfadiazine in aqueous solution and in a simple quasi-two-compartment cell.…”

Section: Introductionmentioning

confidence: 90%

Green electrochemical synthesis of silver sulfadiazine microcrystals

2019

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Electrochemical synthesis of silver sulfadiazine (AgSD) microcrystals was carried out galvanostatically in a special two-electrode cell equipped with a sacrificial silver rod anode and a stainless steel plate cathode. The cell used in this work consists of a small cylindrical chamber containing aqueous sulfadiazine/sodium nitrate as the anode compartment inside a larger cylindrical chamber containing nitric acid solution as the cathode compartment.The ionic connection of two chambers is carried out through a solvent surface layer. In this study, the effect of the experimental parameters such as applied current density and sodium nitrate concentration as well as nitric acid concentration on the yield and energy consumption of AgSD is discussed. The proposed method is fast and green and has unique features including synthesis in a single step, and no need for a metal salt.

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“…Several authors have reported the antimicrobial activity of sulfa drugs and their metal complexes [1][2][3][4] . Studies on their metal chelates could have much physiological and pharmacological relevance, because the metal chelates of sulfa drugs have been found to be more bacteriostatic than the drugs themselves 5 . Besides, silver has been used in medicine for many years 6 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Antimicrobial Screening of Benzene Sulfonamide, 4-Amino-N- (5-Methyl-3-Isoxazolyl) Monosilver Salt and Related Compounds

Herole¹,

Velingkar²

2012

Int J Pharmceut Chem

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ABSTRACT:The synthesis of sulfa drug-metal complexes has received much attention due to their effective application as chemotherapeutic agents to be employed for the prevention and cure of bacterial infection in human being. Further more, sulfa drugs and their metal complexes, posses many applications as diuretic, antiglaucoma, antiepileptic etc 1-2 .The present work report the synthesis, characterization and antimicrobial screening of synthesized silver-sulfa drug complexes.

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Characterization of Silver Sulfadiazine and Related Compounds

Cited by 20 publications

References 4 publications

Silver-Sulfamethazine-Conjugated β-Cyclodextrin/Dextran-Coated Magnetic Nanoparticles for Pathogen Inhibition

Silver-Sulfamethazine-Conjugated β-Cyclodextrin/Dextran-Coated Magnetic Nanoparticles for Pathogen Inhibition

Green electrochemical synthesis of silver sulfadiazine microcrystals

Synthesis, Characterization and Antimicrobial Screening of Benzene Sulfonamide, 4-Amino-N- (5-Methyl-3-Isoxazolyl) Monosilver Salt and Related Compounds

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