Characterization of simultaneous heat, oxygen, and carbon dioxide transfer across a nonporous polydimethylsiloxane (PDMS) hollow fiber membrane

Matula, Emily E.; Nabity, James

doi:10.1016/j.ceja.2021.100106

Cited by 10 publications

(3 citation statements)

References 47 publications

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“…Pumps would keep the media constantly moving, lifting the culture, and reducing temperature and nutrient gradients. Gas transfer would be accomplished by nonporous membranes, allowing for simultaneous carbon dioxide, oxygen, and heat transfer as described in Matula and Nabity (2021) . Interface heat exchangers incorporated into the loops would transfer collected heat from the media to external ammonia loops or radiator systems.…”

Section: Discussionmentioning

confidence: 99%

Supporting Simultaneous Air Revitalization and Thermal Control in a Crewed Habitat With Temperate Chlorella vulgaris and Eurythermic Antarctic Chlorophyta

2021

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Including a multifunctional, bioregenerative algal photobioreactor for simultaneous air revitalization and thermal control may aid in carbon loop closure for long-duration surface habitats. However, using water-based algal media as a cabin heat sink may expose the contained culture to a dynamic, low temperature environment. Including psychrotolerant microalgae, native to these temperature regimes, in the photobioreactor may contribute to system stability. This paper assesses the impact of a cycled temperature environment, reflective of spacecraft thermal loops, to the oxygen provision capability of temperate Chlorella vulgaris and eurythermic Antarctic Chlorophyta. The tested 28-min temperature cycles reflected the internal thermal control loops of the International Space Station (C. vulgaris, 9–27°C; Chlorophyta-Ant, 4–14°C) and included a constant temperature control (10°C). Both sample types of the cycled temperature condition concluded with increased oxygen production rates (C. vulgaris; initial: 0.013 mgO2 L–1, final: 3.15 mgO2 L–1 and Chlorophyta-Ant; initial: 0.653 mgO2 L–1, final: 1.03 mgO2 L–1) and culture growth, suggesting environmental acclimation. Antarctic sample conditions exhibited increases or sustainment of oxygen production rates normalized by biomass dry weight, while both C. vulgaris sample conditions decreased oxygen production per biomass. However, even with the temperature-induced reduction, cycled temperature C. vulgaris had a significantly higher normalized oxygen production rate than Antarctic Chlorophyta. Chlorophyll fluorometry measurements showed that the cycled temperature conditions did not overly stress both sample types (FV/FM: 0.6–0.75), but the Antarctic Chlorophyta sample had significantly higher fluorometry readings than its C. vulgaris counterpart (F = 6.26, P < 0.05). The steady state C. vulgaris condition had significantly lower fluorometry readings than all other conditions (FV/FM: 0.34), suggesting a stressed culture. This study compares the results to similar experiments conducted in steady state or diurnally cycled temperature conditions. Recommendations for surface system implementation are based off the presented results. The preliminary findings imply that both C. vulgaris and Antarctic Chlorophyta can withstand the dynamic temperature environment reflective of a thermal control loop and these data can be used for future design models.

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Section: Discussionmentioning

confidence: 99%

Supporting Simultaneous Air Revitalization and Thermal Control in a Crewed Habitat With Temperate Chlorella vulgaris and Eurythermic Antarctic Chlorophyta

2021

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“…For example, the incorporation of microfluidics with the hanging droplet technique allowed the formation, maintenance and drug resistance assessment of multicellular spheroids [65]. The microfluidic chips were placed in incubators for cell proliferation under controlled CO 2 concentration, temperature and humidity environment [66], while the gas permeable microfluidic materials were used to ensure gas exchange in culture medium [67]. It also contributed for the improvement of microbial suspension culture, while microfluidics also provide oxygen supply and additional nutrients for extended time period (usually in days) to the cell culture platform [23,68].…”

Section: Single-phase Flow Culturementioning

confidence: 99%

Recent advances of integrated microfluidic suspension cell culture system

Kerk

Jameel

Xing

et al. 2021

Engineering Biology

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Microfluidic devices with superior microscale fluid manipulation ability and large integration flexibility offer great advantages of high throughput, parallelisation and multifunctional automation. Such features have been extensively utilised to facilitate cell culture processes such as cell capturing and culturing under controllable and monitored conditions for cell‐based assays. Incorporating functional components and microfabricated configurations offered different levels of fluid control and cell manipulation strategies to meet diverse culture demands. This review will discuss the advances of single‐phase flow and droplet‐based integrated microfluidic suspension cell culture systems and their applications for accelerated bioprocess development, high‐throughput cell selection, drug screening and scientific research to insight cell biology. Challenges and future prospects for this dynamically developing field are also highlighted.

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“…This allows for consistent mass transfer over a long period of time. Reliable gas transport can result in sustainable oxygenation system performance [ 46 ]. PDMS, an elastomeric polymer, has several ideal properties such as nontoxic, transparent, and bioinert and can inhibit microbial growth.…”

Section: Introductionmentioning

confidence: 99%

Novel polymer composite coated with ethylcellulose nanoparticle from waste paper as an alternative material to extracorporeal oxygenation membrane

Pratama,

Lestari,

Rofida

et al. 2023

J Polym Res

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Extracorporeal membrane oxygenator (ECMO) is a valuable technology to support people with acute respiratory distress syndrome (ARDS) and is recommended for COVID-19 patients. This study aims to fabricate polymer-based composite membranes coated with ethylcellulose nanoparticles from waste paper and identify the performance of the composite as ECMO candidates. Composite membranes were made from four types of polymers, namely, nylon, PTFE (polytetrafluoroethylene), Pebax ® MH-1657, and SBS (poly-(styrene-b-butadiene-b-styrene)). PDMS (polydimethylsiloxane) 1 wt.% and ethylcellulose nanoparticles (3% and 10 wt.%) were used as membrane coatings to increase their hydrophobic properties. The success of cellulose isolation and ethylcellulose synthesis from waste paper was confirmed by the FTIR and XRD analysis. The size of the synthesized ethylcellulose nanoparticles was 32.68 nm. The coating effect on composite membranes was studied by measuring the contact angle, membrane porosity, protein quantification tests, and single gas permeation of O 2 and CO 2 . Based on the protein quantification test, the protein could not pass through the Pebax/PDMS and SBS/PDMS composites coated with 10 wt.% ethylcellulose; this indicated less risk of plasma leakage. The gas permeation test on nylon/PDMS, PTFE/PDMS, and SBS/PDMS composites coated with 10% ethylcellulose resulted high CO 2 /O 2 selectivity, respectively, 2.17, 3.48, and 3.22 as good indication for extracorporeal oxygenation membrane. Supplementary Information The online version contains supplementary material available at 10.1007/s10965-023-03576-y.

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Characterization of simultaneous heat, oxygen, and carbon dioxide transfer across a nonporous polydimethylsiloxane (PDMS) hollow fiber membrane

Cited by 10 publications

References 47 publications

Supporting Simultaneous Air Revitalization and Thermal Control in a Crewed Habitat With Temperate Chlorella vulgaris and Eurythermic Antarctic Chlorophyta

Supporting Simultaneous Air Revitalization and Thermal Control in a Crewed Habitat With Temperate Chlorella vulgaris and Eurythermic Antarctic Chlorophyta

Recent advances of integrated microfluidic suspension cell culture system

Novel polymer composite coated with ethylcellulose nanoparticle from waste paper as an alternative material to extracorporeal oxygenation membrane

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