Characterization of skin function associated with obesity and specific correlation to local/systemic parameters in American women

Mori, Shinobu; Shiraishi, Akio; Epplen, Karen; Butcher, Desiree; Murase, Daiki; Yasuda, Yuka; Murase, Takatoshi

doi:10.1186/s12944-017-0608-1

Cited by 31 publications

(45 citation statements)

References 36 publications

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“…Obesity has been associated with decreased collagen deposition and slower wound healing in animal studies 17 . Increased body weight also raises the levels of tumour necrosis factor (TNF) and interleukin‐6, which is an adipose tissue‐derived pro‐inflammatory cytokine 18 . Both cytokines have the potential to induce local skin inflammation and worsen underlying IBD.…”

Section: Discussionmentioning

confidence: 99%

Risk factors and treatment outcomes of peristomal pyoderma gangrenosum in patients with inflammatory bowel disease

Wang

Prenner

Wang

et al. 2020

Aliment Pharmacol Ther

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Background: Insufficient data exist for peristomal pyoderma gangrenosum (PPG), which primarily affects patients with inflammatory bowel disease (IBD). Aims:To evaluate the risk factors and treatment response of PPG in IBD patients in a real-life cohort.Methods: Cases of PPG were identified retrospectively using ICD-9/10 codes in patients with IBD who had an ostomy at a tertiary care centre. Disease-specific characteristics were compared between groups with and without PPG, and response to therapy was evaluated in patients with PPG. Results:The cohort included 41 IBD patients with PPG and 123 IBD controls with an ostomy who never developed PPG. Patients with PPG were more likely to be female (76% vs 51%, P = 0.006), had higher BMIs (29.78 ± 0.89 vs 23.53 ± 0.51, P < 0.0001) and had increased usage of pouch belts (97% vs 71%, P = 0.0008) compared to controls. There were no differences in age at surgery (41.76 ± 2.60 vs 43.49 ± 1.50, P = 0.57) or IBD diagnosis (63% vs 54% Crohn's disease, P = 0.28) between PPG and controls. 85% of PPG patients achieved complete resolution with different treatments, including surgery. Complete resolution with topical corticosteroids and calcineurin inhibitors alone were low (14% and 13% respectively). Higher rates of complete resolution were reported with anti-tumour necrosis factor (TNF) agents (63%) and surgical interventions (80%). Conclusions:Female gender, higher BMI and pouch belts were associated with increased risk of developing PPG. Most PPG cases resolved after treatment with the highest rates of complete resolution seen with anti-TNF agents and surgical intervention.

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Section: Discussionmentioning

confidence: 99%

Risk factors and treatment outcomes of peristomal pyoderma gangrenosum in patients with inflammatory bowel disease

Wang

Prenner

Wang

et al. 2020

Aliment Pharmacol Ther

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“…Following publication of the original article [ 1 ], the authors identified an error. In the description in Fig.…”

Section: Correctionmentioning

confidence: 99%

Correction to: Characterization of skin function associated with obesity and specific correlation to local/systemic parameters in American women

Mori

Shiraishi

Epplen³

et al. 2017

Lipids Health Dis

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“…Recent studies have shown that obesity creates variations in skin physiology 5,29,30 . These changes include but are not limited to skin barrier function, epidermal changes, dermal changes, and changes to the vascular and capillary recruitment function.…”

Section: Introductionmentioning

confidence: 99%

Synthetic Photoplethysmography (PPG) of the radial artery through parallelized Monte Carlo and its correlation to Body Mass Index (BMI)

Boonya-Ananta

Rodriguez

Ajmal

et al. 2020

Preprint

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Cardiovascular disease is one of the leading causes of death in the United States and obesity significantly increases the risk of cardiovascular disease. The measurement of blood pressure (BP) is critical in monitoring and managing cardiovascular disease hence new wearable devices are being developed to make the BP metric mode accessible to physicians and patients. Several wearables utilize photoplethysmography from the wrist vasculature to derive BP assessment although many of these devices are still at the experimental stage. With the ultimate goal of supporting instrument development, we have developed a model the photoplethysmographic waveform derived from the radial artery at the volar surface of the wrist. To do so we have utilized the relation between vessel biomechanics through Finite Element Method and Monte Carlo light transport model. The model shows similar features to that seen in PPG waveform captured using an off the shelf device. We observe the influence of body mass index (BMI) on the PPG signal. A degradation the PPG signal of up to 40% in AC to DC signal ratio was thus observed.

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Characterization of skin function associated with obesity and specific correlation to local/systemic parameters in American women

Cited by 31 publications

References 36 publications

Risk factors and treatment outcomes of peristomal pyoderma gangrenosum in patients with inflammatory bowel disease

Risk factors and treatment outcomes of peristomal pyoderma gangrenosum in patients with inflammatory bowel disease

Correction to: Characterization of skin function associated with obesity and specific correlation to local/systemic parameters in American women

Synthetic Photoplethysmography (PPG) of the radial artery through parallelized Monte Carlo and its correlation to Body Mass Index (BMI)

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