Characterization of Sleep in Aplysia californica

Vorster, Albrecht; Krishnan, Harini C.; Cirelli, Chiara; Lyons, Lisa C.

doi:10.5665/sleep.3992

Cited by 32 publications

(47 citation statements)

References 81 publications

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“…Unlike rodent models, Aplysia do not exhibit any sleep during their active period, maintaining a strong diurnal pattern of activity. 27 Although long-term memory formation in Aplysia is strongly regulated by the circadian clock with training-induced kinase activation and gene expression dependent on the time of training, 94,95 there appear to be no differences in the molecular pathways required for 24 h memory when animals are trained early in the day compared to later in the day, as long as the training still occurs during the animal's active period. Presumably, sleep deprivation interferes with molecular signaling processes affecting the induction of gene expression and protein synthesis necessary for LTM.…”

Section: Discussionmentioning

confidence: 99%

“…Aplysia sleep in consolidated bouts with longer bouts occurring in the first half of the night, demonstrate rebound sleep after sleep deprivation, and exhibit longer latencies to appetitive and aversive stimuli during sleep. 27 The almost complete absence of daytime rest and the lack of fragmentation in the sleep pattern at night, 27 reminiscent of the human sleep pattern, facilitates the study of acute sleep deprivation on the induction of STM and LTM. Aplysia as a model system provides the future potential to study the interactions between sleep and memory at the level of the neuronal circuit as associative and nonassociative learning paradigms have been well characterized.…”

Section: Discussionmentioning

confidence: 99%

“…Sleep in Aplysia occurs during the night in long bouts, with virtually no daytime sleep evident, and is characterized by preferred body position, preferred rest location, and decreased responsiveness to appetitive and aversive sensory stimuli. 27 Following a single night of sleep deprivation, Aplysia exhibit rebound sleep, demonstrating homeostatic as well as circadian regulation of sleep. 27 Aplysia has been an excellent model for dissecting the molecular mechanisms involved in long-term and short-term associative and nonassociative memory formation.…”

Section: Significancementioning

confidence: 99%

“…27 Following a single night of sleep deprivation, Aplysia exhibit rebound sleep, demonstrating homeostatic as well as circadian regulation of sleep. 27 Aplysia has been an excellent model for dissecting the molecular mechanisms involved in long-term and short-term associative and nonassociative memory formation. [28][29][30][31][32][33] The underlying mechanisms of memory formation identified in Aplysia extrapolate to more complex systems as they are highly conserved between vertebrates and invertebrates species.…”

Section: Significancementioning

confidence: 99%

“…Sleep deprivation was performed using context changes every 30 min and tactile stimulation similar to previous studies 27 with slight modifications. Briefly, animals were transferred to individual, chilled, and aerated plastic containers (40 cm × 40 cm) filled with artificial seawater.…”

Section: Sleep Deprivationmentioning

confidence: 99%

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Acute Sleep Deprivation Blocks Short- and Long-Term Operant Memory inAplysia

Krishnan

Gandour

Ramos

et al. 2016

Sleep

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Study Objectives: Insufficient sleep in individuals appears increasingly common due to the demands of modern work schedules and technology use. Consequently, there is a growing need to understand the interactions between sleep deprivation and memory. The current study determined the effects of acute sleep deprivation on short and long-term associative memory using the marine mollusk Aplysia californica, a relatively simple model system well known for studies of learning and memory. Methods: Aplysia were sleep deprived for 9 hours using context changes and tactile stimulation either prior to or after training for the operant learning paradigm, learning that food is inedible (LFI). The effects of sleep deprivation on short-term (STM) and long-term memory (LTM) were assessed. Results: Acute sleep deprivation prior to LFI training impaired the induction of STM and LTM with persistent effects lasting at least 24 h. Sleep deprivation immediately after training blocked the consolidation of LTM. However, sleep deprivation following the period of molecular consolidation did not affect memory recall. Memory impairments were independent of handling-induced stress, as daytime handled control animals demonstrated no memory deficits. Additional training immediately after sleep deprivation failed to rescue the induction of memory, but additional training alleviated the persistent impairment in memory induction when training occurred 24 h following sleep deprivation. Conclusions: Acute sleep deprivation inhibited the induction and consolidation, but not the recall of memory. These behavioral studies establish Aplysia as an effective model system for studying the interactions between sleep and memory formation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Significancementioning

confidence: 99%

Section: Significancementioning

confidence: 99%

Section: Sleep Deprivationmentioning

confidence: 99%

See 3 more Smart Citations

Acute Sleep Deprivation Blocks Short- and Long-Term Operant Memory inAplysia

Krishnan

Gandour

Ramos

et al. 2016

Sleep

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A perspective on neuroethology: what the past teaches us about the future of neuroethology

Beetz

2024

J Comp Physiol A

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For 100 years, the Journal of Comparative Physiology-A has significantly supported research in the field of neuroethology. The celebration of the journal’s centennial is a great time point to appreciate the recent progress in neuroethology and to discuss possible avenues of the field. Animal behavior is the main source of inspiration for neuroethologists. This is illustrated by the huge diversity of investigated behaviors and species. To explain behavior at a mechanistic level, neuroethologists combine neuroscientific approaches with sophisticated behavioral analysis. The rapid technological progress in neuroscience makes neuroethology a highly dynamic and exciting field of research. To summarize the recent scientific progress in neuroethology, I went through all abstracts of the last six International Congresses for Neuroethology (ICNs 2010–2022) and categorized them based on the sensory modalities, experimental model species, and research topics. This highlights the diversity of neuroethology and gives us a perspective on the field’s scientific future. At the end, I highlight three research topics that may, among others, influence the future of neuroethology. I hope that sharing my roots may inspire other scientists to follow neuroethological approaches.

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Roles for sleep in memory: insights from the fly

Donlea

2019

Current Opinion in Neurobiology

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Sleep has been universally conserved across animal species. The basic functions of sleep remain unclear, but insufficient sleep impairs memory acquisition and retention in both vertebrates and invertebrates. Sleep is also a homeostatic process that is influenced not only by the amount of time awake, but also by neural activity and plasticity. Due to the breadth and precision of available genetic tools, the fruit fly has become a powerful model system to understand sleep regulation and function. Importantly, these tools enable the dissection of memory-encoding circuits at the level of individual neurons, and have allowed the development of genetic tools to induce sleep on-demand. This review describes recent investigations of the role for sleep in memory using Drosophila and current hypotheses of sleep's functions for supporting plasticity, learning, and memory.

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Characterization of Sleep in Aplysia californica

Cited by 32 publications

References 81 publications

Acute Sleep Deprivation Blocks Short- and Long-Term Operant Memory inAplysia

Acute Sleep Deprivation Blocks Short- and Long-Term Operant Memory inAplysia

A perspective on neuroethology: what the past teaches us about the future of neuroethology

Roles for sleep in memory: insights from the fly

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