Characterization of Spray Patterns of Inhalation Aerosols Using Thin-Layer Chromatography

Benjamin, Eric J.; Kroeten, Joseph J.; Shek, Efraim

doi:10.1002/jps.2600720415

Cited by 13 publications

(4 citation statements)

References 8 publications

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“…A close similarity was found in flume patterns of two corticosteroid inhalers and the photographic evaluation showed good correlation with the efficiency of drug delivery determined by liquid chromatography. Another study visualized aerosol flumes by using flash photography and nontimed exposures (Benjamin et al 1983). Variations in the size of actuator orifice were found to produce flumes which were not ideal and this observation was confirmed by analysing the spots produced by the aerosol jets on a silica gel thin layer chromatography plate placed at a fixed distance from the actuator.…”

Section: Discussionmentioning

confidence: 98%

High speed photographic analysis of aerosols produced by metered dose inhalers

Dhand

Malik

Balakrishnan

et al. 1988

Journal of Pharmacy and Pharmacology

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The design of pressurized metered dose inhalers (MDI) used to assess asthma is variable. We have examined the aerosol spray flumes generated by four commercially available MDI products using high speed video photography. For this purpose a moulded jacket was designed which could hold the inhaler in an immovable position during actuation. Fresh inhalers were fitted in the jacket after thorough shaking and three successive actuations 30 s apart were filmed with a high speed video camera (200 frames s-1). The aerosol, ejected at high velocity into calm room air, was seen to have a 'jet' phase followed by a 'cloud' phase as a result of particle dispersion. Filming was continued till the flume could no longer be visualized on the TV monitor. High speed photography was used to record flumes seen on the video monitor, to enable characterization of flume appearance, dimensions and mean velocity.

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Section: Discussionmentioning

confidence: 98%

High speed photographic analysis of aerosols produced by metered dose inhalers

Dhand

Malik

Balakrishnan

et al. 1988

Journal of Pharmacy and Pharmacology

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“…Spray pattern is useful in determining the performance of a specific formulation, valve combination and ensures therapeutic performance and batch to batch uniformity[5]. The spray delivered through MDI was impinged onto a glass plate containing activated silica gel-dye mixture.…”

Section: Methodsmentioning

confidence: 99%

Formulation and development of metered dose inhalations of salbutamol in solution form

Khale¹,

Bajaj

2011

Indian J Pharm Sci

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In the present study attempts were made to prepare metered dose inhalation of salbutamol in solution form and compared it with the marketed metered dose inhalation in suspension form. Solution form of the drug was found better than marketed suspension formulation with respect to homogeneity and content uniformity. Propellant blend P-11 and P-12 in the proportion 30:70 was selected as it gave optimum vapour pressure. Surfactant oleic acid in concentration 10 mg per can was selected as it gave best results with clarity, spray pattern, vapour pressure, content per spray and rate of evaporation. Ethyl alcohol 2 ml per can was used as a cosolvent to give a clear solution, optimum vapour pressure, maximum content per spray and fair rate of evaporation. The selected formulation was subjected to the physico-chemical evaluation tests as per the standard pharmacopoeial procedures and the characteristics of the formulations were further compared with a conventional marketed formulation. In vitro study reveled the net respirable fraction was better than marketed preparation.

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“…Spray pattern is useful in determining the performance of a specific formulation-valve combination and ensures therapeutic performance 9 . In addition the test serves as a check on batch to batch uniformity of aerosols.…”

Section: Spray Patternmentioning

confidence: 99%

Untitled

2011

IJPSR

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The direct delivery of therapeutically active drug to the pulmonary tract has proved to be a life saving tool for many Asthmatics. Salbutamol being a drug of choice in severe Asthma attacks, in the present study attempt was made to prepare MDI of Salbutamol in suspension formulation and compare it with the marketed MDI of salbutamol suspension. The proportion of C.F.C. propellant blend (p11 & p12) in 30:70 proportion gave optimum vapor pressure; in the range of 70-75 psig was selected. Oleic acid was selected as a surfactant and its concentration was optimized. A series of physicochemical tests were performed simultaneously on both the preparations. Results were compared. The formulations were further subjected to in-vitro evaluation whereby net respirable fraction was determined. Logic behind this study was to create a better suspension than that available in the market. In all qualitative as well as quantitative tests the formulated suspension was comparable with marketed MDI. However our formulation retained minimum amount of drug (8.57%) on adaptor compared to the marketed preparation (10.40%). This shows the maximum availability of the drug in the pulmonary tract.

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Characterization of Spray Patterns of Inhalation Aerosols Using Thin-Layer Chromatography

Cited by 13 publications

References 8 publications

High speed photographic analysis of aerosols produced by metered dose inhalers

High speed photographic analysis of aerosols produced by metered dose inhalers

Formulation and development of metered dose inhalations of salbutamol in solution form

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