Characterization of Star Adhesive Sealants Based On PEG/Dextran Hydrogels

Artzi, Natalie; Shazly, Tarek; Crespo, Cristina; Ramos, Adriana Bon; Chenault, H. Keith; Edelman, Elazer R.

doi:10.1002/mabi.200800355

Cited by 71 publications

(61 citation statements)

References 27 publications

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“…[15] Dermabond 1 in contrast, is a much stronger adhesive, [16] and in glueing chamois leather we found high adhesive strength values of approximately 0.4 MPa. The adhesive bond strength of the TMPE-TMC based networks was found to be even better than that of Dermabond 1 .…”

mentioning

confidence: 77%

Development of Tissue Adhesives Based on Amphiphilic Isocyanate‐Terminated Trimethylene Carbonate Block Copolymers

Bochynska

Sharifi

Tienen

et al. 2013

Macromolecular Symposia

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Summary: In this study, novel 3-armed star-shaped isocyanate-terminated block copolymers based on trimethylolpropane ethoxylate (TMPE) and trimethylene carbonate (TMC) varying in composition were designed and synthesized. By reaction with water, networks were formed. The characteristics of these networks were compared with those prepared from analogous linear structures based on polyethylene glycol (PEG) and TMC. Tensile testing of the networks highlighted good mechanical properties. In lap shear adhesion tests to chamois leather, very good bonding strengths of up to 0.6 MPa were obtained. These values compare favorably with those of Dermabond 1 , which is currently one of the strongest clinically used tissue adhesives.

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mentioning

confidence: 77%

Development of Tissue Adhesives Based on Amphiphilic Isocyanate‐Terminated Trimethylene Carbonate Block Copolymers

Bochynska

Sharifi

Tienen

et al. 2013

Macromolecular Symposia

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“…Cytotoxicity and proliferation of 3T3 rat fi broblast tests revealed that PEG/dextran was signifi cantly less cytotoxic than octyl cyanoacrylate. The highermolecular-weight dextran aldehyde exhibited lower cytotoxicity as well as higher proliferation [ 95 ] .…”

Section: Peg-based Sealantmentioning

confidence: 98%

“…PEG/dextran aldehyde was developed as biocompatible tissue adhesive [ 95 ] . It consisted of a relatively short-chain PEG polymer (linear PEG of 2 kDa or 8-arm PEG of 10 kDa) containing amine-terminated groups and dextran-containing aldehyde groups.…”

Section: Peg-based Sealantmentioning

confidence: 99%

Sealants (Adhesives) to Prevent Bleeding

Suzuki

Ikada

2011

Biomaterials for Surgical Operation

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In general, surgical sealants (adhesives) are liquids and form gels when applied. Currently, several products are clinically available, including naturally derived fi brin sealants, semisynthetic products such as gelatin and albumin-based glues, and synthetic products including cyanoacrylates and poly(ethylene glycol). These products, however, have both advantages and disadvantages. While fi brin sealants have been successfully used in many surgical fi elds, they have several disadvantages including low adhesive strength. Other products, such as cyanoacrylates and protein-based products, have high adhesion strength but have high toxicity, and therefore, their applications are limited. Studies are still ongoing in order to develop sealants with higher adhesion strength and safer properties compared to the sealants that are currently available. This chapter reviews the chemistry and applications of clinically available sealants and recent developments in this fi eld.

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“…PEG replete with amine groups and oxidized dextran react at body temperature in a Schiff base reaction to form adhesive materials as aldehydes bind to tissue amines. The reaction is reversible and the material hydrolyzes to its polymeric components 16,17 . Although PEG polymers may undergo enzymatic degradation, significant fluid uptake and swelling dominate the degradation of our formulated PEG:dextran hydrogels, resulting in hydrolyticsensitive materials.…”

Section: Hhs Public Accessmentioning

confidence: 99%

Erratum: In vivo and in vitro tracking of erosion in biodegradable materials using non-invasive fluorescence imaging

Artzi¹,

Oliva²,

Puron³

et al. 2011

Nature Mater

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The design of erodible biomaterials relies on the ability to program the in vivo retention time, which necessitates real-time monitoring of erosion. However, in vivo performance cannot always be predicted by traditional determination of in vitro erosion 1,2 , and standard methods sacrifice samples or animals 3 , preventing sequential measures of the same specimen. We harnessed non-invasive fluorescence imaging to sequentially follow in vivo material-mass loss in order to model the degradation of materials hydrolytically (PEG:dextran hydrogel) and enzymatically (collagen). Hydrogel erosion rates in vivo and in vitro correlated, enabling the prediction of in vivo erosion of new material formulations from in vitro data. Collagen in vivo erosion was used to infer physiologic in vitro conditions that mimic erosive in vivo environments. This approach enables rapid in vitro screening of materials, and can be extended to simultaneously determine drug release and material erosion from a drug-eluting scaffold, or cell viability and material fate in tissue-engineering formulations.Users may view, print, copy, download and text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms 3,10,11,12,13 . Chromatography tracks molecular weight changes 2,12 but cannot be applied to eliminable materials that do not undergo chain scission. Material environment affects erosion, and the material and degradation products may affect the environment in turn 14,15 . Thus, in vivo residence times and in vitro durability of three dimensional degradable structures differ 2 . HHS Public AccessWe developed a noninvasive imaging technique that tracks material erosion in vivo through a fluorescent tag covalently attached to components of model materials. Materials erosion was calculated from the decay in total material fluorescence signal using non-invasive In Vivo Imaging System (IVIS). Model hydrolytically degradable adhesive materials used herein are based on polyethylene glycol (PEG) amine and dextran aldehyde 16,17 . PEG replete with amine groups and oxidized dextran react at body temperature in a Schiff base reaction to form adhesive materials as aldehydes bind to tissue amines. The reaction is reversible and the material hydrolyzes to its polymeric components 16,17 . Although PEG polymers may undergo enzymatic degradation, significant fluid uptake and swelling dominate the degradation of our formulated PEG:dextran hydrogels, resulting in hydrolyticsensitive materials. As material shape dictates fluid uptake, we examined whether fluorescence tracking could distinguish the fate of PEG:dextran formulations cast in a series of shapes, sizes and varied PEG solid content. Compressed denatured type II collagen was used as a model for enzymatically degradable material whose erosion profile should change with implantation site and natural variation in enzyme content.To enable the use of tagged materials to ...

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Characterization of Star Adhesive Sealants Based On PEG/Dextran Hydrogels

Cited by 71 publications

References 27 publications

Development of Tissue Adhesives Based on Amphiphilic Isocyanate‐Terminated Trimethylene Carbonate Block Copolymers

Development of Tissue Adhesives Based on Amphiphilic Isocyanate‐Terminated Trimethylene Carbonate Block Copolymers

Sealants (Adhesives) to Prevent Bleeding

Erratum: In vivo and in vitro tracking of erosion in biodegradable materials using non-invasive fluorescence imaging

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