Characterization of surface property of poly(lactide-co-glycolide) after oxygen plasma treatment

Influence of Shear Stress in Perfusion Bioreactor Cultures for the Development of Three-Dimensional Bone Tissue Constructs: A Review

“…Various experimental setups, parallel plate flow chambers, [24][25][26][27][28][29][30][31][32] rotating disc [33][34][35][36][37] or radial flow devices, 38,39 cone and plate viscometers, 40 jet impingement 24 systems, and microfluidic apparatus, 41,42 have been utilized for applying flows in two-dimensional (2D) systems and examining the effect of shear stress on cell monolayers. In 3D systems, fluid agitation is essential in reducing mass transfer constraints associated with concentration gradients at the fluid-construct boundary interface 43,44 ; it has long been known that diffusion of oxygen and soluble nutrients to the construct core can become critically limited in longer term static cultures as tissue growth and extracellular matrix (ECM)/mineralization occurs, 45,46 resulting in a necrotic core with an external shell of viable tissue.…”

“…Numerous groups have shown that increasing the hydrophilicity or wettability of surface materials enhances cellular attachment strength. 25,28,30,31,37,41 In addition to the surface chemistry, Deligianni et al 33 showed that increasing surface roughness aided attachment strength, whereas further augmentation of the adhesion surfaces, by coating with biological ligands, has yielded improvements dependent upon ligand type 24,27,35 and proportional to ligand density. 26,32,36,39,42 Xiao and Truskey demonstrated that maintaining the native conformation of the ligand appears to be advantageous in conferring stronger ligand-receptor bonds 32 in comparison to using linear fragments.…”

Surface modified cellulose scaffolds for tissue engineering

“…However, synthetic biomaterials suffer from a major disadvantage as they often lack sites for cell adhesion; therefore, many need to be modified to introduce cell attachment cues, such as matrix ligands, for adhesion (O'Brien 2011). The addition of ligands or peptides may be achieved by passive adsorption (simplest method) (Cutler and García 2003), or more complex routes such as incorporation into the polymer backbone (Schmedlen et al 2002), at the ends of the polymer chains (Hersel et al 2003), or functionalised on the material surfaces (Wan et al 2004). In general, these approaches involve complex chemistries, or costly crosslinking reagents that are unstable after a short period of time, adding cost and complexity to production.…”

Non-Thermal Plasma Surface Modification of Biodegradable Polymers

“…Two possible wet-chemical routes are surface aminolysis and surface hydrolysis. Surface aminolysis in for example 1,6-hexanediamine leads to the production of free amino groups on the surface of the polyester which improves cell adhesion (Zhu et al, 2002, Zhu et al, 2004. By applying surface hydrolysis with the use of a NaOH solution, the ester group is hydrolyzed by the hydroxide anion leading to a rupture of the polymer chain and the formation of carboxylic acid and hydroxyl groups on the tail ends of the two new chains.…”

“…By applying surface hydrolysis with the use of a NaOH solution, the ester group is hydrolyzed by the hydroxide anion leading to a rupture of the polymer chain and the formation of carboxylic acid and hydroxyl groups on the tail ends of the two new chains. The presence of these groups results in an enhanced hydrophilicity and in improved cellmaterial interactions (Zhu et al, 2002, Zhu et al, 2004. Although these wet-chemical processes have their merit, some disadvantages cannot be neglected.…”