Characterization of Suspicious Microcalcifications on Mammography Using 2D Shear-Wave Elastography

Kayadibi, Yasemin; Uçar, Neşe; Kaya, Mehmet; Yıldırım, Emine; Bektaş, Sibel

doi:10.1016/j.ultrasmedbio.2021.05.008

Cited by 6 publications

(11 citation statements)

References 55 publications

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“…Consistent with the results of previous studies, our study also showed a significant correlation between tumor stiffness and poor prognostic features of breast cancer, including older age, larger tumor size, lymph node metastasis, and higher tumor stage. Several studies have demonstrated that the presence of calcifications in breast lesions is correlated with increased mean elasticity values on SWE [28][29][30]. However, the impact of microcalcification on elastography in breast cancer remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Ultrasound Elastography and Fibrotic Focus and Their Association in Breast Cancer

Lee

Jeong

2022

JCM

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(1) Background: Ultrasound (US) elastography is an imaging technology that reveals tissue stiffness. This study aimed to investigate whether fibrotic focus (FF) affects elastographic findings in breast cancer, and to evaluate the clinical significance of US elastography and FF in breast cancer. (2) Methods: In this study, 151 patients with breast cancer who underwent surgery were included. Strain elastography was performed and an elasticity scoring system was used to assess the findings. The elasticity scores were classified as negative, equivocal, or positive. FF was evaluated in the surgical specimens. Medical records were reviewed for all patients. (3) Results: Elastographic findings were equivocal in 30 patients (19.9%) and positive in 121 patients (80.1%). FF was present in 68 patients (46.9%). There was no correlation between elastographic findings and FF. Older age, larger tumor size, lymph node metastasis, and higher tumor stage were associated with positive elastographic results. FF showed a positive correlation with age, postmenopausal status, tumor size, lymphovascular invasion, lymph node metastasis, tumor stage, and intratumoral and peritumoral inflammation. (4) Conclusions: Our study showed that positive elastographic results and FF were associated with poor prognostic factors for breast cancer. FF did not affect the elastographic findings of this study.

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Section: Discussionmentioning

confidence: 99%

Clinical Significance of Ultrasound Elastography and Fibrotic Focus and Their Association in Breast Cancer

Lee

Jeong

2022

JCM

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“…Our previous study using virtual touch tissue quantification imaging with Emax has proven its value in the differential diagnosis between benign and malignant FLLs[ 9 ]. 2D-SWE is one of the most advanced elastography techniques and could provide overall elastic information in tumors and locate the stiffest part[ 20 ]. In this study, the cutoff point of Emax was 1.905, which was similar to our previous result[ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Differential diagnosis of different types of solid focal liver lesions using two-dimensional shear wave elastography

Guo¹,

Dong²,

Qian³

et al. 2022

WJG

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BACKGROUND The clinical management and prognosis differ between benign and malignant solid focal liver lesions (FLLs), as well as among different pathological types of malignant FLLs. Accurate diagnosis of the possible types of solid FLLs is important. Our previous study confirmed the value of shear wave elastography (SWE) using maximal elasticity (Emax) as the parameter in the differential diagnosis between benign and malignant FLLs. However, the value of SWE in the differential diagnosis among different pathological types of malignant FLLs has not been proved. AIM To explore the value of two-dimensional SWE (2D-SWE) using Emax in the differential diagnosis of FLLs, especially among different pathological types of malignant FLLs. METHODS All the patients enrolled in this study were diagnosed as benign, malignant or undetermined FLLs by conventional ultrasound. Emax of FLLs and the periphery of FLLs was measured using 2D-SWE and compared between benign and malignant FLLs or among different pathological types of malignant FLLs. RESULTS The study included 32 benign FLLs in 31 patients and 100 malignant FLLs in 96 patients, including 16 cholangiocellular carcinomas (CCCs), 72 hepatocellular carcinomas (HCCs) and 12 liver metastases. Thirty-five FLLs were diagnosed as undetermined by conventional ultrasound. There were significant differences between Emax of malignant (2.21 ± 0.57 m/s) and benign (1.59 ± 0.37 m/s) FLLs ( P = 0.000), and between Emax of the periphery of malignant (1.52 ± 0.39 m/s) and benign (1.36 ± 0.44 m/s) FLLs ( P = 0.040). Emax of liver metastases (2.73 ± 0.99 m/s) was significantly higher than that of CCCs (2.14 ± 0.34 m/s) and HCCs (2.14 ± 0.46 m/s) ( P = 0.002). The sensitivity, specificity and accuracy were 71.00%, 84.38% and 74.24% respectively, using Emax > 1.905 m/s (AUC 0.843) to diagnose as malignant and 23 of 35 (65.74%) FLLs with undetermined diagnosis by conventional ultrasound were diagnosed correctly. CONCLUSION Malignant FLLs were stiffer than benign ones and liver metastases were stiffer than primary liver carcinomas. 2D-SWE with Emax was a useful complement to conventional ultrasound for the differential diagnosis of FLLs.

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“…The correlation between two-dimensional shear-wave elastography (2D-SWE) and histopathological results of microcalci cations (MCS) was performed using ultrasonography (USG) (Kayadibi et al, 2021). Fifty people with suspected MCS were evaluated.…”

Section: Literature Reviewmentioning

confidence: 99%

A novel machine learning approach on texture analysis for automatic breast microcalcification diagnosis classification of mammogram images

Sarvestani

Jamali

Taghizadeh

et al. 2023

J Cancer Res Clin Oncol

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Screening programs use mammography as a diagnostic tool for the early detection of breast cancer.Mammogram enhancement is used to increase the local contrast of the mammogram so that the lesions are more visible in the advanced image. For accurate diagnosis in the early stage of breast cancer, the appearance of masses and microcalci cation on the mammographic image are two important indicators.The objective of this study was to evaluate the feasibility of automatic separation of images of breast tissue microcalci cations and also to evaluate its accuracy by using two techniques of image enhancement and highlighting of breast tissue microcalci cations for the desired areas by regional ROI based on fuzzy system and also Gabor ltering method. After determining the clusters of breast tissue microcalci cations, the clusters are classi ed using the decision tree classi cation algorithm. Then, for segmentation, samples suspected of microcalci cation are highlighted and masked, and in the last stage, tissue characteristics are extracted. Subsequently, with the help of arti cial neural network (ANN), determining the benign and malignant types of segmented ROI clusters was accomplished. The proposed system is trained with a Digital Database for Screening Mammography (DDSM) developed by the University of South Florida, USA, and the simulations are performed under MATLAB software and the results are compared with previous work. The results of this training performed under this work show an accuracy of 93% and an improvement of sensitivity above 95%, which indicates that the proposed approach can be applied to ensure breast cancer diagnosis.

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Characterization of Suspicious Microcalcifications on Mammography Using 2D Shear-Wave Elastography

Cited by 6 publications

References 55 publications

Clinical Significance of Ultrasound Elastography and Fibrotic Focus and Their Association in Breast Cancer

Clinical Significance of Ultrasound Elastography and Fibrotic Focus and Their Association in Breast Cancer

Differential diagnosis of different types of solid focal liver lesions using two-dimensional shear wave elastography

A novel machine learning approach on texture analysis for automatic breast microcalcification diagnosis classification of mammogram images

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