Characterization of Talaromyces purpureogenus strain F extrolites and development of production medium for extracellular pigments enriched with antioxidant properties

Parul, .; General, Thiyam; Dufossé, Laurent; Sharma, Ashok

doi:10.1016/j.fbp.2020.08.012

Cited by 12 publications

(9 citation statements)

References 42 publications

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“…Therefore, a big challenge in pigments production is to obtain pure extracts, containing fewer substances and, preferably, with only one color [ 19 ]. Figure 12 presents some fungal species and associated fermentative parameters that resulted in the production of yellow [ 66 , 80 , 81 , 82 , 83 , 84 ], orange [ 14 , 85 ] or red [ 14 , 79 , 85 , 86 , 87 , 88 , 89 ] pigments. However, in most of the works, yellow, orange and red azaphilones are produced simultaneously (cocktail pigments phenomenon) in different proportions.…”

Section: Processing and Innovations In Azaphilones Productionmentioning

confidence: 99%

“…Carbon source in the fermentation is a very major parameter to direct fungal metabolism. Parul et al [ 83 ] demonstrated that mannitol is the best carbon source for reproduction and growth of T. purpureogenus strain F, but the growth is accompanied by low yield of pigment production, while sucrose causes the opposite effect. The authors correlate this fact to species and strain-specific capacity to produce specific enzymes that will dictate the fungus priorities.…”

Section: Processing and Innovations In Azaphilones Productionmentioning

confidence: 99%

“…The authors correlate this fact to species and strain-specific capacity to produce specific enzymes that will dictate the fungus priorities. Under no stressing conditions and abundant carbon availability, primary metabolism is prioritized and the metabolism will be directed to biomass productions instead of secondary metabolites production [ 83 ]. In addition, the rate of carbon source depletion is also important.…”

Section: Processing and Innovations In Azaphilones Productionmentioning

confidence: 99%

“…In the same way, culture medium agitation and aeration ensure better distribution of nutrients and better growth, but at the expense of faster depletion of carbon sources. Therefore, agitation and aeration are factors that must be strictly controlled in industrial production [ 83 ].…”

Section: Processing and Innovations In Azaphilones Productionmentioning

confidence: 99%

“… Conditions reported for color-directed production of yellow, orange and red azaphilones [ 14 , 67 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 ]. …”

Section: Figurementioning

confidence: 99%

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Recent Findings in Azaphilone Pigments

Pimenta

Gomes

Cardoso

et al. 2021

JoF

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Filamentous fungi are known to biosynthesize an extraordinary range of azaphilones pigments with structural diversity and advantages over vegetal-derived colored natural products such agile and simple cultivation in the lab, acceptance of low-cost substrates, speed yield improvement, and ease of downstream processing. Modern genetic engineering allows industrial production, providing pigments with higher thermostability, water-solubility, and promising bioactivities combined with ecological functions. This review, covering the literature from 2020 onwards, focuses on the state-of-the-art of azaphilone dyes, the global market scenario, new compounds isolated in the period with respective biological activities, and biosynthetic pathways. Furthermore, we discussed the innovations of azaphilone cultivation and extraction techniques, as well as in yield improvement and scale-up. Potential applications in the food, cosmetic, pharmaceutical, and textile industries were also explored.

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Section: Processing and Innovations In Azaphilones Productionmentioning

confidence: 99%

Section: Processing and Innovations In Azaphilones Productionmentioning

confidence: 99%

Section: Processing and Innovations In Azaphilones Productionmentioning

confidence: 99%

Section: Processing and Innovations In Azaphilones Productionmentioning

confidence: 99%

“… Conditions reported for color-directed production of yellow, orange and red azaphilones [ 14 , 67 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 ]. …”

Section: Figurementioning

confidence: 99%

See 3 more Smart Citations

Recent Findings in Azaphilone Pigments

Pimenta

Gomes

Cardoso

et al. 2021

JoF

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Production and stability of pigments by Talaromyces purpurogenus LC128689 in an alternating air phase–liquid phase cultivation system

Ugwu

Ogbonna

et al. 2021

Biotech and App Biochem

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Effects of carbon source, nitrogen source, and alternatingly submerging the cells and exposing to gaseous oxygen on pigment production by Talaromyces purpurogenus LC128689, as well as pH, temperature, and UV stability of the pigments were investigated. Although fructose supported higher cell growth, a mixture of glucose and glycerol resulted in higher pigment production. Out of the organic and inorganic nitrogen sources investigated, peptone gave the highest cell concentration (7.2 ± 1.1 g/L) and pigment production (p ≤ 0 .05). The cells were then immobilized in loofa sponge and cultivated under alternating liquid phaseair phase (ALAP) system whereby the cells were alternatingly submerged and exposed to gaseous oxygen. After 20 days of cultivation, the concentrations of the red, orange, and yellow pigments were 30.15 AU 500 nm , 15 AU 460 nm , and 6.25 AU 400 nm , respectively. In comparison with submerged culture in flasks, the red and orange pigments were 100% and 50% higher (p ≤ 0.05) in ALAP system. On the other hand, the yellow pigment was 100% higher in flask cultures than in ALAP. The three pigments were stable within a pH range of 2-12, retained more than 80% of their color intensity after autoclaving at (121 • C and 1.0 atm) for 15 min and exposure to UV (3 uW/cm 2 ) for 24 h.

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