Characterization of thalassemia major and diabetes mellitus patients at a reference center in Brazil

Olivatto, Gabriela Marsola; Teixeira, Carla Regina de Souza; Sisdelli, Marcela Ganzella; Zanetti, María Lúcia; Silveira, Renata Cristina de Campos Pereira; Gonçalves, Claudio Vinicius

doi:10.1016/j.htct.2018.08.005

Cited by 7 publications

(7 citation statements)

References 10 publications

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“…However a study found 16.1% of thalassemic patients had diabetes. 19 Another study noted that the incidence of diabetes in thalassemia children was 17.5%. 9 Frequency of first cousin consanguinity was 100 (67 %) and of 2 nd cousin were 48 (33 %).…”

Section: Discussionmentioning

confidence: 99%

“…9 Another study state that there may be role of deficiency of insulin, dysfunction of liver and genetic impact of consanguinity that may start in early. 11,19 Additionally a study found that due to regular transfusions, pancreatic iron may cause impaired glucose tolerance and overt diabetes. 9 Limitations: Study has no information of iron load, only estimated via the iron take through transfusion.…”

Section: Discussionmentioning

confidence: 99%

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Impact of consanguinity marriage on developing type 1 diabetes of beta thalassemia children

Khurshid¹,

Fatima²,

Hamza³

et al. 2021

JAFMDC

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Objective: To find impact of consanguinity marriage on developing diabetes in a group of thalassemia children. Methodology: A cross sectional study carried out from October 2016 to June 2017at thalassemia centers of Lahore city. One hundred and fifty beta thalassemia major children with age range 4 to 8 years receiving regular blood transfusion were recruited by purposive sampling. Structured questionnaires were filled by the consented parents of children. Results: Among total number of thalassemia patients, the frequency of male was100 and of female was 50. The frequency of male and female diabetic thalassemia children was 25 (25 %) and 25 (50%) respectively. Frequency of general consanguinity was 148(98.66%). Weak correlation of fasting blood sugar with consanguinity in diabetic thalassemia children was observed. Conclusion: Consanguinity marriages may have a role on developing diabetes in thalassemia children.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Impact of consanguinity marriage on developing type 1 diabetes of beta thalassemia children

Khurshid¹,

Fatima²,

Hamza³

et al. 2021

JAFMDC

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“…The damage sustained by β-cells under iron overload in TDT and NTDT impairs insulin production and leads to hyperglycemia and diabetes. Iron overload also negatively alters the proper functioning of pancreatic β-cells and reduces their insulin production capacity early on during the development of glucose intolerance [20]. Iron overload in β-thalassemia patients could lead to insulin resistance, where elevated blood sugar levels develop because of diminished responsiveness to insulin.…”

Section: Possible Links Between β-Thalassemia and Diabetesmentioning

confidence: 99%

“…1). Therefore, long-term monitoring and management are essential to delay or mitigate anemia, skeletal deformities, heart failure, and diabetes among other complications [18][19][20]. This article aims to review the evidence linking diabetes with β-thalassemia major and explore the utility of early prediction biomarkers and the mechanism(s) underlying this association.…”

Section: Introductionmentioning

confidence: 99%

β-Thalassemia and Diabetes Mellitus: Current State and Future Directions

Taneera,

Mahgoub,

Qannita

et al. 2023

Horm Metab Res

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Abstractβ-Thalassemia major is a congenital hemoglobin disorder that requires regular blood transfusion. The disease is often associated with iron overload and diabetes mellitus, among other complications. Pancreatic iron overload in β-thalassemia patients disrupts β-cell function and insulin secretion and induces insulin resistance. Several risk factors, including family history of diabetes, sedentary lifestyle, obesity, gender, and advanced age increase the risk of diabetes in β-thalassemia patients. Precautionary measures such as blood glucose monitoring, anti-diabetic medications, and healthy living in β-thalassemia patients notwithstanding, the prevalence of diabetes in β-thalassemia patients continues to rise. This review aims to address the relationship between β-thalassemia and diabetes in an attempt to understand how the pathology and management of β-thalassemia precipitate diabetes mellitus. The possible employment of surrogate biomarkers for early prediction and intervention is discussed. More work is still needed to better understand the molecular mechanism(s) underlying the link between β-thalassemia and diabetes and to identify novel prognostic and therapeutic targets.

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“…The toxic effect of iron accumulation in beta and acinar cells of pancreas in addition to peripheral resistance to insulin can be the main mechanism through which patients with BTM develop diabetes. 7 However, most of the alterations that occurred in the pancreas are caused by an iron overload which has not been accentuated using chelators. The prevalence of diabetes mellitus in patients with BTM varies from 9.7% to 29%.…”

mentioning

confidence: 99%

Investigation of Pancreatic Sonography Findings in Patients With Beta-Thalassemia Major

Behzadmehr

Shahramian

Rahimi

et al. 2021

Journal of Diagnostic Medical Sonography

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Objective: Some structural abnormalities have been reported on sonography of pancreas in patients with beta-thalassemia which can indicate that the patient is developing diabetes. In this study, the aim was to investigate the findings of pancreatic sonography in patients, with beta-thalassemia major. Methods: This cross-sectional study included information extracted from the medical record and entered into an information form. A cohort of 190 people were split into case and control groups, retrospectively. The required data were extracted from patient’s documents. Data were analyzed with SPSS software, version 22; with the chi-square statistical tests. A P value of < .05 was considered statistically significant. Results: This study consisted of 33 males and 61 females in the case group and 32 males and 64 females in the control group. The most common echogenicity observed during pancreatic sonography, in the control group, was an isoechoic feature (72.3%), followed by hyper and hypoechogenicity (18.1% and 9.6%, respectively). The prevalence of an isoechoic texture in the patient case group was 58.3%, while hyper and hypoechogenicity were seen in 26% and 2.1%, respectively ( P = .070). There was a poor negative correlation between diabetes and pancreatic echogenicity ( P = .002 and r = −.226). Also, there was a poor positive correlation between fasting serum glucose levels and pancreatic echogenicity ( P = .034, n = 96 and r = .217). Conclusion: This study demonstrates, in this patient group, that there was a poor relationship between pancreatic head size with serum ferritin levels and pancreatic echogenicity with diabetes. These results may suggest using sonography to diagnose early stages of diabetes in patients with thalassemia.

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Characterization of thalassemia major and diabetes mellitus patients at a reference center in Brazil

Cited by 7 publications

References 10 publications

Impact of consanguinity marriage on developing type 1 diabetes of beta thalassemia children

Impact of consanguinity marriage on developing type 1 diabetes of beta thalassemia children

β-Thalassemia and Diabetes Mellitus: Current State and Future Directions

Investigation of Pancreatic Sonography Findings in Patients With Beta-Thalassemia Major

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