2022
DOI: 10.1016/j.biopha.2022.113759
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Characterization of the activity and the mechanism of action of a new toluquinol derivative with improved potential as an antiangiogenic drug

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Cited by 2 publications
(2 citation statements)
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“…Endothelial cells constitutively secrete MMP-2, which is required to trigger tumor angiogenesis in vitro and in vivo [56,57]. A decrease in the production of MMP-2 by endothelial cells has been observed with other angiogenesis inhibitors [8,9,11,13,34,58]. Our data show that incubation with danthron significantly inhibited the MMP-2 secretion by HUVEC.…”
Section: Discussionsupporting
confidence: 66%
See 1 more Smart Citation
“…Endothelial cells constitutively secrete MMP-2, which is required to trigger tumor angiogenesis in vitro and in vivo [56,57]. A decrease in the production of MMP-2 by endothelial cells has been observed with other angiogenesis inhibitors [8,9,11,13,34,58]. Our data show that incubation with danthron significantly inhibited the MMP-2 secretion by HUVEC.…”
Section: Discussionsupporting
confidence: 66%
“…Cell redox capacity was determined by measuring the disulfide reduction by endothelial and tumor cells as previously described [34]. Cells were treated for 24 or 48 h with tested compounds in 6-well plates (DMSO and 10, 25 or 50 µM of danthron), and they were washed three times with cold PBS supplemented with 1 mM CaCl 2 and 0.5 mM MgCl 2 .…”
Section: Determination Of Sulfhydryl Groupsmentioning
confidence: 99%