Abstract. Weighted anisotropic Triebel-Lizorkin spaces are introduced and studied with the use of discrete wavelet transforms. This study extends the isotropic methods of dyadic ϕ-transforms of Jawerth (1985, 1989) to non-isotropic settings associated with general expansive matrix dilations and A ∞ weights.In close analogy with the isotropic theory, we show that weighted anisotropic Triebel-Lizorkin spaces are characterized by the magnitude of the ϕ-transforms in appropriate sequence spaces. We also introduce non-isotropic analogues of the class of almost diagonal operators and we obtain atomic and molecular decompositions of these spaces, thus extending isotropic results of Frazier and Jawerth.