Characterization of the bile acid profile in developing male and female hamsters in response to dietary cholesterol challenge

Effects of dietary alpha linolenic acid on cholesterol metabolism in male and female hamsters of the LPN strain

“…In our hamsters, the concentration of hepatic LDL receptors was the same in males and females, which is consistent with the absence of difference in LDL-C. Actually, in the hamster, the effect of gender on LDL-C concentration appears to be strain-dependent. Indeed, females of strains prone to atherosclerosis, such as the F1B, exhibit lower LDL-C than males [32,33], whereas no gender-related differences were noted in strains prone to biliary cholesterol gallstones, which is the case of the LPN strain used in the present study [62]. The same discrepancy with epidemiological data appears for HDL metabolism.…”

“…This contrasts with the human, in which HDL-C is higher in women than in men [59]. Again, a strain-related sensitivity is to be involved [62,33]. The data were analyzed with a two-way (diet and gender as factors) analysis of variance (ANOVA) and the significance level was preset at P Ͻ 0.05.…”

Alteration of sphingolipid metabolism and pSTAT3 expression by dietary cholesterol in the gallbladder of hamsters

“…The consumption of cholesterol-enriched diets leads to increased plasma cholesterol concentrations in most animal species, including humans, but the degree of the responsiveness differs according to the species and the individuals within a species (Chen et al, 1998). The serum levels of total cholesterol, LDL cholesterol and triglycerides in cholesterol-fed hamsters were elevated and associated with gallstone formation in our experiment and others (Trautwein et al, 1999). The serum cholesterol level appears to be the prerequisite to the development of liver injury, which may be related to the altered lipid metabolism associated with the changes in the levels of lipid metabolites in the serum and bile.…”

Mathematically modelling the dynamics of cholesterol metabolism and ageing

“…For example, aged female rodents often have an increased concentration of serum bile acids, whereas levels remain constant in males with age (Fu et al, 2012). This is in addition to alterations to the composition of bile acids (Trautwein et al, 1999). Gut microflora are also affected by the ageing process.…”