Characterization of the biological antioxidant potential in the vitreous fluid from patients with rhegmatogenous retinal detachment

Maeno, Atsuko; Suzuki, Yukihiko; Adachi, Kobu; Takahashi, Saburo; Yokoi, Yuki; Nakazawa, Makoto

doi:10.1111/aos.13002

Cited by 9 publications

(22 citation statements)

References 6 publications

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“…previously reported the BAP values and levels of inflammatory cytokines in the vitreous fluid from patients with RRD [15,21]. In those studies, we found that the BAP was significantly decreased while the levels of macrophage chemotactic factor-1 (MCP-1), macrophage inflammatory protein-1β (MIP-1β), interferon-inducible 10-kDa protein (IP-10), interleukin-6 (IL-6), and IL-8 were significantly increased in the vitreous fluid in RRD patients, indicating significantly increased oxidative stress and inflammatory reaction on the retinal cells [15,21].…”

Section: Journal Of Clinical and Experimental Ophthalmologymentioning

confidence: 97%

“…systemTM (Wismerll, Tokyo, Japan) in line with the manufacturer's instructions as previously reported [15]. In brief, the solution is initially colorized when Fe 3+ ions are dissolved in the thiocyanate derivative solution (colored solution), and after addition of the vitreous samples, the Fe 3+ ions are reduced to Fe 2+ , which causes decolorization of the solution.…”

Section: Quantitative Analyses Of Bapmentioning

confidence: 99%

“…An analysis of variance (ANOVA) was employed to examine whether there was any statistical difference among members in the same group, or not. In addition to the results previously reported, [15] we performed multivariate regression analysis conducted using a stepwise method, and incorporated the extent of the detachment, duration of symptoms, vitreous status, macular status and patient age as the independent variables for the analysis of the BAP.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…These findings demonstrated that differences in age were not a concern and would not cause problems in any of our further analyses. The BAP values in the examined disorders were previously reported [15] and are summarized in Table 2. In brief, the results showed that the BAP values were statistically distinguishable among the five groups by ANOVA.…”

Section: Vitreous Bap In the Examined Disordersmentioning

confidence: 99%

“…In many vitreoretinal disorders, oxidative stress has been implicated as a factor inducing the development of retinal cellular damage [1]. These disorders include proliferative diabetic retinopathy (PDR), [2][3][4][5] retinitis pigmentosa, [6][7][8][9] age-related macular degeneration, [10][11][12][13] and rhegmatogenous retinal detachment (RRD) [14,15]. Furthermore, previous experimental studies have revealed that photoreceptor cells themselves have the potential to produce reactive oxygen species (ROS) by NAPDH oxidase when they are stressed by the deprivation of serum in culture conditions [16].…”

Section: Introductionmentioning

confidence: 99%

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Oxidative Stress in the Vitreous Fluid with Rhegmatogenous Retinal Detachment

Suzuki¹,

Adachi²,

Takahashi³

et al. 2017

J Clin Exp Ophthalmol

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Purpose: To characterize the biological antioxidant potential (BAP) in the vitreous fluid in patients with rhegmatogenous retinal detachment (RRD).Design: Laboratory investigation. Materials and methods:Undiluted vitreous fluid was obtained at the time of vitrectomy from patients with RRD (45 eyes), proliferative diabetic retinopathy (PDR, 93 eyes), retinal vein occlusion (14 eyes), epiretinal membrane (ERM, 18 eyes) and macular hole (MH, 24 eyes). The BAP values were determined by measuring the reducing potential shown by the conversion of Fe 3+ to Fe 2+. Clinical features including the extent of the detachment, duration of symptoms, presence of proliferative vitreoretinopathy or vitreous hemorrhaging, and macular status (on or off), as well as the patient age were analyzed.Results: RRD patients exhibited a significantly lower BAP than MH patients, and PDR patients had a significantly lower BAP than ERM and MH patients. Regarding the clinical features, although the BAP in RRD patients was significantly correlated with the extent of the detached area (β=−0.384, p=0.008), there was no significant correlation between the BAP and the other features in a multivariate regression analysis. Discussion:The present results suggest that significantly increased oxidative stress was present in RRD patients compared to MH Patients. Controlling oxygen stress may be an effective treatment for photoreceptor protection in cases of RRD.

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Section: Journal Of Clinical and Experimental Ophthalmologymentioning

confidence: 97%

Section: Quantitative Analyses Of Bapmentioning

confidence: 99%

Section: Statistical Analysesmentioning

confidence: 99%

Section: Vitreous Bap In the Examined Disordersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Oxidative Stress in the Vitreous Fluid with Rhegmatogenous Retinal Detachment

Suzuki¹,

Adachi²,

Takahashi³

et al. 2017

J Clin Exp Ophthalmol

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Electrolyte, Nitric Oxide and Oxidative Stress Levels of Aqueous Humor in Patients with Retinal Detachment and Silicone Oil Tamponade

Kars

Toklu

Yorgun

et al. 2020

Current Eye Research

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Profiles of Inflammatory Cytokines in the Vitreous Fluid from Patients with Rhegmatogenous Retinal Detachment and Their Correlations with Clinical Features

Takahashi

Adachi

Suzuki

et al. 2016

BioMed Research International

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Purpose. To characterize the profiles for inflammatory cytokines in the vitreous fluid from patients with rhegmatogenous retinal detachment (RRD) by comparing those of other vitreoretinal diseases and to analyze the correlation between intravitreal cytokines and clinical features. Materials and Methods. Vitreous fluid was obtained at the time of surgery from 28 RRD eyes. Vitreous fluid was similarly collected from patients with macular hole (MH), epiretinal membrane, proliferative diabetic retinopathy (PDR), and retinal vein occlusion as controls. Twenty-seven cytokines were measured. Intravitreal cytokine profiles in RRD were characterized by comparing these with those in other vitreoretinal diseases. We also analyzed the correlations between vitreous cytokines and clinical features. Results. There were statistical differences in the MCP-1, MIP-1β, and IP-10 between the RRD and MH, while the IL-6 and IL-8 exhibited levels that were between those for the PDR and MH. MIP-1β was significantly correlated to both the extent and duration of the RRD, while IL-8 was significantly correlated to the extent of the RRD. Conclusions. MCP-1, MIP-1β, and IP-10 may modify the pathologic features of RRD. The levels of these cytokines are related in part to the clinical features and the level of photoreceptor damage.

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Characterization of the biological antioxidant potential in the vitreous fluid from patients with rhegmatogenous retinal detachment

Cited by 9 publications

References 6 publications

Oxidative Stress in the Vitreous Fluid with Rhegmatogenous Retinal Detachment

Oxidative Stress in the Vitreous Fluid with Rhegmatogenous Retinal Detachment

Electrolyte, Nitric Oxide and Oxidative Stress Levels of Aqueous Humor in Patients with Retinal Detachment and Silicone Oil Tamponade

Profiles of Inflammatory Cytokines in the Vitreous Fluid from Patients with Rhegmatogenous Retinal Detachment and Their Correlations with Clinical Features

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