1977
DOI: 10.1016/0002-9149(77)90187-4
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Characterization of the “border zone” in acute regional ischemia in the dog

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Cited by 147 publications
(25 citation statements)
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“…This latter surface was employed in constructing the replicas and is here termed the "ischemic margin." This finding is in agreement with that of Hearse et al 25 who noted that the polarity change occurred several millimeters outside the cyanotic demarcation.…”
Section: Resultssupporting
confidence: 93%
“…This latter surface was employed in constructing the replicas and is here termed the "ischemic margin." This finding is in agreement with that of Hearse et al 25 who noted that the polarity change occurred several millimeters outside the cyanotic demarcation.…”
Section: Resultssupporting
confidence: 93%
“…The x-ray angiogram should thus be made from myocardial sections that are relatively thin. In the present study, the left ventricle was sectioned into eight rings; this resulted in small epi-endo samples that were then combined from different rings to provide a sample size greater than 1 g. The view that a zone of intermediate ischemia and injury constitutes a significant fraction of the ischemic region is supported by a variety of studies [histochemical (Vokonas et al, 1978;Cox et al, 1968), biochemical (Cox et al, 1968;Hearse et al, 1977;Kjekshus and Sobel, 1970), myocardial blood flow (Becker et al, 1973;Vokonas et al, 1978;Jugdutt et al, 1979aJugdutt et al, , 1979bJugdutt et al, , 1980, and electrocardiographic (Maroko et al, 1971(Maroko et al, , 1977Braunwald et al, 1974)]. It is apparent that intermediate reductions in blood flow or injury may result if a tissue sample that is analyzed contains an admixture of nonischemic and ischemic myocardium and that the dimension of the zone will depend on the technique for sampling.…”
Section: Discussionmentioning
confidence: 96%
“…Considerable controversy exists concerning the transitional or border zone between ischemic and nonischemic zones. One view is that the ischemic region consists of a central zone of greatest ischemia that is surrounded by significant transitional zones characterized by intermediate reductions in blood flow (Becker et al, 1973;Jugdutt et al, 1979aJugdutt et al, , 1979bVokonas et al, 1978), intermediate myocardial injury, and incomplete necrosis (Vokonas et al, 1978;Cox et al, 1968;Hearse et al, 1977;Kjekshus and Sobel, 1970;Maroko et al, 1971Maroko et al, , 1977Braunwald et al, 1974;Sobel and Shell, 1973). According to this concept, transitional zones of intermediate ischemia result from preferential perfusion via the nonoccluded vasculature that borders the ischemic region.…”
Section: (Circ Res 52: 451 -459 1983)mentioning
confidence: 99%
“…16,1996 ATF3 RESPONDS TO STRESSES 1165 loop shape is reminiscent of the border zone reported previously (25). Hearse et al described concentric zones of different degrees of ischemia and postulated that gradients of metabolism and electrophysiology may exist in these zones (25). It is not clear, however, whether the loop-shaped expression of ATF3 is related to the border zone phenomenon.…”
Section: Induction Of Atf3 By Stress Signals Is An Early Eventmentioning
confidence: 99%