“…The involvement of secondary alcohol metabolites in anthracyclineinduced cardiomyopathy is indicated by the evidence presented in several biochemical, pharmacokinetic, and genetic studies (Minotti et al, 2004;Salvatorelli et al, 2006;Gianni et al, 2008;Mordente et al, 2009;Ferguson et al, 2015). Anthracycline alcohol metabolite formation is catalyzed mainly by distinct cytosolic NADPH-dependent oxidoreductases (Mordente et al, 2003;Jin and Penning, 2007;Oppermann, 2007;Bains et al, 2010;Malátková et al, 2010;Blanco et al, 2012) that metabolize a broad range of endogenous and exogenous carbonyl-containing compounds, including steroids, eicosanoids, cofactors, neurotransmitters, and polyols (Jin and Penning, 2007;Oppermann, 2007;Bains et al, 2010;Malátková et al, 2010).…”