Characterization of the coronary vascular β‐adrenoceptor in the pig

Drew, G. M.; Levy, Gerhard

doi:10.1111/j.1476-5381.1972.tb06880.x

Cited by 44 publications

(13 citation statements)

References 16 publications

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“…Atria are generally assumed to-contain mainly /,-type receptors. In isolated coronary arteries from other species /#,-adrenoceptors also appear to predominate (Baron, Speden & Bohr, 1972;Drew & Levy, 1972;Cornish & Miller, 1974 uptake inhibitors metaraminol, cocaine and desipramine all failed to potentiate responses to noradrenaline and nerve stimulation. Phenoxybenzamine could not be tested at an effective concentration for inhibition of neuronal (or extraneuronal) uptake since it markedly reduced responses to the spasmogen, acetylcholine.…”

Section: Discussionmentioning

confidence: 93%

Effects of Uptake Inhibitors on Responses of Sheep Coronary Arteries to Catecholamines and Sympathetic Nerve Stimulation

Brine¹,

Cornish²,

Miller³

1979

British J Pharmacology

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1 Transmural stimulation of intrinsic sympathetic nerves and exogenous catecholamines produce /I-adrenoceptor mediated relaxant responses in strips of contracted sheep coronary artery.2 The neuronal uptake inhibitors, metaraminol, cocaine and desipramine and the extraneuronal uptake inhibitor, cortisol, failed to potentiate responses to noradrenaline or sympathetic stimulation; responses to isoprenaline were enhanced by cortisol. 3 Oxytetracycline, which inhibits binding to connective tissue fibres, did not affect responses to noradrenaline or nerve stimulation. 4 17,B-Oestradiol, caffeine and U0521 proved to be unsuitable compounds for studying catecholamine inactivation since they non-selectively potentiated responses to noradrenaline and isoprenaline. 5 It is concluded that catecholamine inactivation processes do not modify transmitter function in sheep coronary arteries.

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Section: Discussionmentioning

confidence: 93%

Effects of Uptake Inhibitors on Responses of Sheep Coronary Arteries to Catecholamines and Sympathetic Nerve Stimulation

Brine¹,

Cornish²,

Miller³

1979

British J Pharmacology

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“…In fact, there was conflicting evidence about the nature of /3-adrenoceptors in coronary vascular smooth muscle. Baron et al, 33 Drew and Levy, 38 and Johansson 39 concluded that /3-adrenoceptors of canine and porcine coronary arteries were /3,-type. On the other hand, Bayer et al 40 suggested that /3-adrenoceptors of porcine coronary artery are different from those of the myocardium and belong to the /3 2 -type.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of adrenoceptors and [3H]nitrendipine receptors of porcine vascular smooth muscle: differences between coronary artery and aorta.

Nishimura¹,

Kobayashi²,

Nakamura³

1987

Circulation Research

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“…Norepinephrine contracted the strips duced by 10-4 M papaverine were taken as 100%; mean absolute values in the control arteries (e) and those treated with 10-6 M (0) metoprolol were 346 ± 38 (n = 7) and 349 ± 63 mg (n = 7), respectively, and those in control arteries (e) and those treated with 10-6 (0) and 10-5 M (x) butox amine were 349 ± 44 (n = 8), 309 ± 39, (n = 8), and 296 ± 4 1 mg (n = 8), (Drew and Levy, 1972), kitten (Cornish and Miller, 1975), rat (Nyborg and Mikkelsen, 1985), and bovine coro nary arteries (Purdy and Stupecky, 1986). …”

Section: Discussionmentioning

confidence: 90%

Regional Difference in the Response Mediated by β₁-Adrenoceptor Subtype in Bovine Cerebral Arteries

Ayajiki

Toda

1992

J Cereb Blood Flow Metab

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Summary: Helical strips of bovine rostral cerebral arter ies (anterior cerebral, middle cerebral, and internal ca rotid artery) responded to norepinephrine with contrac tions, whereas the caudal cerebral arteries (posterior communicating, posterior cerebral, and basilar artery) re laxed in response to the amine. After blockade of a-adrenoceptors, norepinephrine-induced rostral artery contractions were reversed to relaxations, which were smaller than those in the caudal arteries. Isoproterenol, dobutamine, and terbutaline produced greater relaxations in caudal than in rostral arteries, but forskolin relaxed these arteries to a similar magnitude. The isoproterenol induced relaxation was not affected by removal of the endothelium. Maximal relaxations induced by terbutaline Large arteries distributing to the base of the brain are thought to be important in regulating CBF (Kon tos et al., 1978). These arteries are innervated adrenergically; according to histochemical studies, noradrenergic nerves are more dense in the rostral than in the caudal part of rat and cat cerebral arter ies (Edvinsson, 1975;Kobayashi, 1981 507in caudal arteries were much inferior to those by isopro terenol, norepinephrine, and dobutamine. Relaxations caused by isoproterenol, norepinephrine, and terbutaline in the caudal arteries were attenuated by metoprolol, but not influenced by butoxamine. Relaxations mediated pos sibly by 131-adrenoceptor subtype are greater in bovine caudal cerebral arteries than in the rostral arteries. The heterogeneity does not appear to be associated with the different ability of cyclic AMP to relax arterial smooth muscle but with the difference of l3-adrenoceptor popu lations and/or processes from the receptors to adenylate cyclase. Key Words: Cerebral artery-Regional differ ence-N orepinephrine-Isoproterenol-Terbutaline Forskolin-Metoprolol-131-adrenoceptor subtype. MATERIALS AND METHODSCerebral arteries were isolated from the bovine brain, which was obtained from a slaughterhouse within 30 min after death of the animal. The arteries (1.0-1.3 mm out side diameter) used for this series of experiments were as

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Characterization of the coronary vascular β‐adrenoceptor in the pig

Cited by 44 publications

References 16 publications

Effects of Uptake Inhibitors on Responses of Sheep Coronary Arteries to Catecholamines and Sympathetic Nerve Stimulation

Effects of Uptake Inhibitors on Responses of Sheep Coronary Arteries to Catecholamines and Sympathetic Nerve Stimulation

Characteristics of adrenoceptors and [3H]nitrendipine receptors of porcine vascular smooth muscle: differences between coronary artery and aorta.

Regional Difference in the Response Mediated by β₁-Adrenoceptor Subtype in Bovine Cerebral Arteries

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Characterization of the coronary vascular β‐adrenoceptor in the pig

Cited by 44 publications

References 16 publications

Effects of Uptake Inhibitors on Responses of Sheep Coronary Arteries to Catecholamines and Sympathetic Nerve Stimulation

Effects of Uptake Inhibitors on Responses of Sheep Coronary Arteries to Catecholamines and Sympathetic Nerve Stimulation

Characteristics of adrenoceptors and [3H]nitrendipine receptors of porcine vascular smooth muscle: differences between coronary artery and aorta.

Regional Difference in the Response Mediated by β1-Adrenoceptor Subtype in Bovine Cerebral Arteries

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Regional Difference in the Response Mediated by β₁-Adrenoceptor Subtype in Bovine Cerebral Arteries