Characterization of the Coronary Vasodilator and Hemodynamic Actions of Monensin, A Carboxylic Ionophore

Rk, Saini; Rk, Hester; Somani, Pitambar; Bc, Pressman

doi:10.1097/00005344-197901000-00012

Cited by 28 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The increased weight of the heart as a percent of body weight observed in this experiment may be due to myocardial enlargement. Monensin has been reported to stimulate the contraction of the cardiac muscle, increase cardiac blood flow, and reduce peripheral resistance (Sutko et al, 1975;Saini et al, 1979). Monensin transports calcium poorly, compared to sodium, and the primary effect is to alter sodium, which in turn, modulates calcium and alters the contractile state of the myocardium (Bassett et al, 1978).…”

Section: Discussionmentioning

confidence: 99%

The Potential of Monensin for Body Weight Control and Ad Libitum Feeding of Broiler Breeders from Day-Old to Sexual Maturity

Oyawoye

Krueger

1986

Poultry Science

View full text Add to dashboard Cite

A total of 180 male and 360 female day-old Indian River broiler breeder chicks were randomly allocated to 18 floor pens in an open-sided pullet brooding and growing house. The birds were subjected to six growing systems that were a combination of three levels of monensin (100, 300, and 400 ppm) and two levels of starter crude protein (CP) (14 and 18% CP) in a randomized complete block design. The basal diets were formulated to be isocaloric, containing 2920 kcal ME/kg. Birds fed 100 ppm of monensin were feed restricted and served as controls, while birds fed 300 or 400 ppm of the drug were fed ad libitum from day-old to sexual maturity. The parameters determined were biweekly individual body weights, feed consumption, internal organ weights, bone and serum mineral composition, and mortality to 21 weeks of age. In general, birds fed high levels of monensin plus ad libitum feeding from day-old were more variable in body weight compared to the feed-restricted controls. In the females, high levels of monensin in the diet were associated with significant reductions in body weight, even with ad libitum feeding, to 21 weeks of age. Male birds fed 300 ppm of the drug were significantly heavier than the feed-restricted controls but were still within the range recommended at this age. High levels of monensin in the diet were associated with a significant reduction in cumulative ad libitum feed consumption compared to the feed-restricted controls.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Section: Discussionmentioning

confidence: 99%

The Potential of Monensin for Body Weight Control and Ad Libitum Feeding of Broiler Breeders from Day-Old to Sexual Maturity

Oyawoye

Krueger

1986

Poultry Science

View full text Add to dashboard Cite

show abstract

“…Although early efforts to discover novel inotropes that influence sodium homeostatis focused on agents like monensin [34], which is a sodium ionophore, recent efforts have been directed towards increasing sodium influx into cardiac muscle by directly stimulating the voltage-dependent sodium fast channel [44]. Sodium-channel stimulating activity has been identified for a variety of natural products, most notably various polypeptides extracted from the sea anemone [45].…”

Section: Sodium Channel Stimulatorsmentioning

confidence: 99%

New mechanisms for positive inotropic agents: Focus on the discovery and development of imazodan

Weishaar¹,

Kobylarz-Singer²,

Klinkefus³

1989

Cardiovasc Drug Ther

View full text Add to dashboard Cite

Intense efforts during the last decade to identify a useful positive inotropic agent to replace digitalis for the treatment of congestive heart failure have led to the discovery of several dozen potential substitutes, of which a number are currently undergoing clinical trials. In addition to producing a variety of new therapeutic entities, research in this area has also yielded valuable new information regarding the fundamental events that regulate calcium homeostasis and contractile function in the cardiac cell. For example, several of these new inotropic agents, including the calcium-channel stimulator BAY-k 8644, the sodium-channel stimulator DPI-201-186, and the sodium-calcium exchange inhibitor dichlorobenzamil, have provided considerable insight into the role of sodium and calcium in regulating contractility and the molecular events that mediate potential-dependent ion channels. Likewise, the discovery and development of agents like imazodan, amrinone, enoximone, and other selective type III phosphodiesterase inhibitors have provided new information regarding multiple molecular forms of cyclic nucleotide phosphodiesterase, compartmentation of cyclic AMP, and the importance of soluble vs. membrane-bound phosphodiesterases.

show abstract

“…Efforts to identify the mechanism of the in situ coronary vasodilation by monensin have not been conclusive. In one study, a /S-adrenergjc antagonist reversed the monensin-induced coronary vasodilation in the dog (deGuzman and Pressman, 1975), whereas, in another study, aminophylline (an adenosine antagonist), but not propranolol, attenuated this vasodilator action of monensin (Saini et al, 1979). In yet another group of experiments, neither pretreatment was effective .…”

mentioning

confidence: 98%

“…In the anesthetized dog, monensin elicits dose-dependent increases in myocardial contractility, aortic blood pressure, cardiac output, and coronary blood flow, and decreases in total peripheral resistance Saini et al, 1979). A recent study by Pressman and Painter (1982) has emphasized that the positive inotropic effect of monensin on the myocardium is caused by an increase in intracellular sodium concentration and the resultant stimulation of sodium-calcium exchange.…”

mentioning

confidence: 99%

“…A recent study by Pressman and Painter (1982) has emphasized that the positive inotropic effect of monensin on the myocardium is caused by an increase in intracellular sodium concentration and the resultant stimulation of sodium-calcium exchange. The cardiotonic effects are partially antagonized by practolol, propranolol, and H87/07 (/3-adrenergic antagonists) Shlafer et al, 1975;Sutko et al, 1977;Shlafer et al, 1978;Saini et al, 1979). Efforts to identify the mechanism of the in situ coronary vasodilation by monensin have not been conclusive.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Mechanism of canine coronary artery relaxation by monensin.

Anderson

Winquist

Webb³

et al. 1983

Circulation Research

View full text Add to dashboard Cite

Monensin is a monocarboxylic sodium ionophore which causes increased myocardial contractility and increased coronary blood flow in the anesthetized dog. The current experiment investigated the mechanism by which monensin produces relaxation of smooth muscle from the canine coronary artery. Helical strips of coronary artery were mounted in a muscle chamber and made to contract by stimulation with 5-hydroxytryptamine. First, concentration-response curves were established for the relaxant effect of added monensin. Then the following agents were evaluated for their effects on the monensin-induced inhibition of contraction to 5-hydroxytryptamine: aminophylline, indomethacin, propranolol, ouabain, and a potassium-free solution. Finally, the effect of added monensin on potassium-induced relaxation of denervated coronary artery strips was used to further characterize this relaxant effect. The results demonstrate that monensin causes coronary smooth muscle relaxation at the same concentrations reported to cause a positive inotropic effect in isolated myocardial preparations. The monensin-induced inhibition of contraction of the isolated coronary artery was not blocked by aminophylline, propranolol, or indomethacin, demonstrating that the inhibition is not mediated by adenosine, by /3-adrenergic receptors, or by prostaglandins. The inhibition of coronary smooth muscle contraction was completely blocked by ouabain or by a potassium-free solution. Monensin also potentiated potassiuminduced relaxation of both innervated and denervated coronary artery strips; both the potassiuminduced relaxation and the potentiation of this relaxation by monensin were ouabain-blocked. We conclude that monensin produces coronary relaxation by stimulation of Na + ,K + -ATPase. This stimulation may result from a monensin-induced increase in intracellular sodium ion concentration similar to the change that, paradoxically, mediates the positive inotropic effect in the myocardium. (CircRes 53: 168-175, 1983)

show abstract

Characterization of the Coronary Vasodilator and Hemodynamic Actions of Monensin, A Carboxylic Ionophore

Cited by 28 publications

References 0 publications

The Potential of Monensin for Body Weight Control and Ad Libitum Feeding of Broiler Breeders from Day-Old to Sexual Maturity

The Potential of Monensin for Body Weight Control and Ad Libitum Feeding of Broiler Breeders from Day-Old to Sexual Maturity

New mechanisms for positive inotropic agents: Focus on the discovery and development of imazodan

Mechanism of canine coronary artery relaxation by monensin.

Contact Info

Product

Resources

About