Characterization of the Cross-Linked Structure of Hydrogels

Peppas, Nikolaos A.; Barr-Howell, Barbara D.

doi:10.1201/9780429285097-2

Cited by 23 publications

(31 citation statements)

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“…This hydrogel parameter, also known as pore (mesh) size ξ relates to the M c and is dependent first for M c to be found by using the Peppas–Merrill or other predictive models . In 1986, the Peppas and Bar–Howell equation predicts ξ as the average distance between two consecutive macromolecular chains,

ξ = {υ_{2, s}}^{- 1 / 3} {(\frac{2 C_{n} M_{c}}{M_{r}})}^{1 / 2} ℓ

where C n is the characteristic ratio of the comonomers and ℓ is the carbon–carbon bond distance …”

Section: Introductionmentioning

confidence: 99%

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Effect of network mesh size and swelling to the drug delivery from pH responsive hydrogels

Hegab

Pardue

Shen

et al. 2019

J of Applied Polymer Sci

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pH responsive hydrogels are ideal platforms for numerous therapeutic delivery applications, including oral delivery, as they are capable of overcoming the many barriers that must be considered when creating an effective drug delivery system. Understanding of the innate hydrogel network structure and its swelling behavior at environmentally relevant conditions is vital for designing hydrogel network capable of effective controlled drug release. Herein, we explored how to expand traditional techniques of swelling and pore characterization to gain better insight into the performance of anionic microparticles composed of the poly(methyl methacrylate‐co‐acrylic acid) with varying molar percentage of 10, 20, and 30 mol% of MMA, for controlled release of low‐molecular‐weight drugs. By evaluating these carrier systems at environmental conditions, we can observe changes in swelling and pore size of the anionic hydrogel networks as a function of MMA, which was then correlated with the release profiles of the small‐molecular‐weight drug sodium nitrate. With the correlation of the swelling behavior of the networks and the release profiles, we demonstrated how the expansion of swelling parameters at relevant pH values provides further incite for evaluating for the optimal blend for controlled release. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48767.

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ξ = {υ_{2, s}}^{- 1 / 3} {(\frac{2 C_{n} M_{c}}{M_{r}})}^{1 / 2} ℓ

where C n is the characteristic ratio of the comonomers and ℓ is the carbon–carbon bond distance …”

Section: Introductionmentioning

confidence: 99%

“…where C n is the characteristic ratio of the comonomers and ℓ is the carbon-carbon bond distance. 18,23 The number average molecular weight can experimentally be determined for a copolymer without any crosslinking agent. Rather than measuring M n experimentally, Foss et al proposed an equation the value of M n for a copolymer network.…”

Section: Introductionmentioning

confidence: 99%

Effect of network mesh size and swelling to the drug delivery from pH responsive hydrogels

Hegab

Pardue

Shen

et al. 2019

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…As redes poliméricas intumescem pela sua imersão em solvente apropriado. Mudanças dimensionais, ou aumento no peso das redes intumescidas, podem ser comparadas ao material não intumescido para determinação do grau de reticulação [32,71].…”

Section: Intumescimentounclassified

“…Este polímeros tem sido usados como curativos de ferida [84] e seu emprego na medicina vem aumentando [50]. Os polímeros sintéticos utilizados para esta função correspondem aos hidrogéis que, de acordo com as condições de preparação, podem adquirir formato de membranas, as quais apresentam resistência à manipulação e, de acordo com o grau de reticulação, formam redes de poros suficientemente grandes para diversas aplicações [71].…”

Section: Introductionunclassified

“…OH ligados lateralmente a sua cadeia[70]. Suas aplicações são relacionadas ao desenvolvimento de sistemas de liberação controlada de drogas[71], como prótese para disco intervertebral[25], como parte de membranas para curativo de feridas[87], etc. microorganismos como fonte de armazenamento de energia ou parte estrutural[28].Os polissacarídeos podem ser degradados por hidrólise quando em solução, ou mesmo por hidrólise enzimática.…”

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