Characterization of the cytosolic estrogen receptor in rat skeletal muscle

Dahlberg, Erik

doi:10.1016/0304-4165(82)90381-6

Cited by 65 publications

(32 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Insulin, however, increases protein synthesis in skeletal muscle (see, for example, Young, 1980) unlike zeranol in this study. There is also evidence of oestrogen binding to skeletal muscle from male and female rats (Dub6 et al 1976, Dahlberg, 1982.…”

Section: Discussionmentioning

confidence: 99%

Effects of trenbolone acetate and zeranol on protein metabolism in male castrate andfemale lambs

1983

View full text Add to dashboard Cite

1. Tissue composition and skeletal muscle cathepsin D (EC 3 . 4 . 2 3 . 5 ) activity were measured in wether lambs treated with trenbolone acetate (TBA) and oestradiol-17P (Oe) in combination and female lambs treated with TBA or zeranol. Muscle and liver protein fractional synthesis rates and plasma leucine flux were measured in the female lambs.2. Male castrate lambs treated with TBA plus Oe showed increased growth rate, improved food conversion efficiency, decreased muscle RNA concentration and decreased total cathepsin D activity in muscle.3. Female lambs treated with TBA or zeranol showed increased weight gain, improved food conversion efficiency, decreased muscle RNA and DNA concentrations and decreased free cathepsin D activity in muscle. Mixed muscle protein fractional synthesis rate was decreased after TBA treatment. Plasma leucine flux, not corrected for oxidation or food intake, was not increased by TBA or zeranol treatment.4. Treatment of female lambs with TBA or zeranol caused increased growth rate. This increased growth rate is probably due in part to decreased muscle protein degradation, since evidence was obtained that muscle protein synthesis is decreased by TBA and zeranol treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of trenbolone acetate and zeranol on protein metabolism in male castrate andfemale lambs

1983

View full text Add to dashboard Cite

show abstract

“…Estrogen receptors are present in skeletal muscle, 23 the largest component of fat-free mass, suggesting that estrogen may have a direct effect in maintaining various tissue components of fat-free mass. Menopause-related changes in growth factors may also contribute to changes in fatfree tissue mass.…”

Section: Fat-free and Skeletal Muscle Massmentioning

confidence: 99%

Effect of menopausal status on body composition and abdominal fat distribution

et al. 2000

View full text Add to dashboard Cite

OBJECTIVE: Preliminary studies suggest that the menopause transition is associated with deleterious changes in body composition and abdominal fat distribution. Limitations of the methodology used in these studies, however, render their conclusions controversial. Thus, the present study used radiologic imaging techniques to examine the effect of menopausal status on body composition and abdominal fat distribution. DESIGN: Cross-sectional. SUBJECTS: Fifty-three healthy, middle-aged, premenopausal women (mean AE SD; 47 AE 3 y) and 28 early-postmenopausal women (51 AE 4 y). MEASUREMENTS: Total and regional body composition by dual energy X-ray absorptiometry and abdominal fat distribution by computed tomography. RESULTS: No differences in total body fat-free mass or appendicular skeletal muscle mass were noted between groups. In contrast, total body fat mass was 28% higher (23 AE 7 vs 18 AE 7 kg) and percentage fat 17% higher (35 AE 6 vs 30 AE 9%; both P`0.01) in postmenopausal women compared with premenopausal women. Postmenopausal women had a 49% greater intra-abdominal (88 AE 32 vs 59 AE 32 cm 2 ; P`0.01) and a 22% greater abdominal subcutaneous fat area (277 AE 93 vs 227 AE 108 cm 2 ; P`0.05) compared to premenopausal women. The menopause-related difference in intra-abdominal fat persisted (P`0.05) after statistical adjustment for age and total body fat mass, whereas no difference in abdominal subcutaneous fat was noted. A similar pattern of differences in total and abdominal adiposity was noted in sub-samples of pre-and postmenopausal women matched for age or fat mass. CONCLUSION: Our data suggest that early-postmenopausal status is associated with a preferential increase in intraabdominal fat that is independent of age and total body fat mass.

show abstract

“…Women are at higher risk of suffering fibromyalgia, rheumatoid arthritis, and hypermobility and sustain more connective tissue injuries than men, and this may be related to exposure to different sex hormones. Estrogen and progesterone receptors have been localized in synoviocytes and fibroblast from muscle and tendon tissue samples from animals (7,8,30) and human beings (19,30), and in vitro studies with increasing estrogen availability have shown a dose-dependent decrease in collagen synthesis rate and fibroblast proliferation in tissue samples from the human anterior cruciate ligament (20,37,38). Furthermore, in a well-designed study by Toth et al (33) it was demonstrated that ovariectomized rats increased muscle protein synthetic rates and lean body mass compared with sham-operated controls.…”

mentioning

confidence: 99%

No effect of menstrual cycle on myofibrillar and connective tissue protein synthesis in contracting skeletal muscle

Miller¹,

Hansen

Olesen

et al. 2006

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

-We tested the hypothesis that acute exercise would stimulate synthesis of myofibrillar protein and intramuscular collagen in women and that the phase of the menstrual cycle at which the exercise took place would influence the extent of the change. Fifteen young, healthy female subjects were studied in the follicular (FP, n ϭ 8) or the luteal phase (LP, n ϭ 7, n ϭ 1 out of phase) 24 h after an acute bout of one-legged exercise (60 min of kicking at 67% W max), samples being taken from the vastus lateralis in both the exercised and resting legs. Rates of synthesis of myofibrillar and muscle collagen proteins were measured by incorporation of [13 C]leucine. Myofibrillar protein synthesis (means Ϯ SD; rest FP: 0.053 Ϯ 0.009%/h, LP: 0.055 Ϯ 0.013%/h) was increased at 24-h postexercise (FP: 0.131 Ϯ 0.018%/h, P Ͻ 0.05, LP: 0.134 Ϯ 0.018%/h, P Ͻ 0.05) with no differences between phases. Similarly, muscle collagen synthesis (rest FP: 0.024 Ϯ 0.017%/h, LP: 0.021 Ϯ 0.006%/h) was elevated at 24-h postexercise (FP: 0.073 Ϯ 0.016%/h, P Ͻ 0.05, LP: 0.072 Ϯ 0.015%/h, P Ͻ 0.05), but the responses did not differ between menstrual phases. Therefore, there is no effect of menstrual cycle phase, at rest or in response to an acute bout of exercise, on myofibrillar protein synthesis and muscle collagen synthesis in women. stable isotopes; estrogen; exercise WE RECENTLY SHOWED THAT, in young healthy men, the rates of both myocellular proteins and intramuscular collagen (probably mostly peri-and epimysium) increased in response to an acute bout of exercise (24). Despite women having a smaller muscle mass than men (14), attempts to detect sex differences in protein metabolism have produced little evidence of their existence. There have been some reports of differences between the sexes in the rate of leucine oxidation at rest and during exercise (16,22,34) but there is no convincing evidence of major differences in whole body protein turnover and mixed-muscle protein synthesis (13,16,22,26,31,34) between the sexes, even after corrections for different sizes of fat-free mass (13,34). Furthermore, it is reported that men and women do not have different rates of muscle protein synthesis in response to exercise (31). The lower protein mass in women may therefore be the result of an accumulated sex-specific hormonal effect on synthesis or breakdown over a period of many years (32), or female sex hormones may influence protein synthesis in fractions of muscle, that are masked when measurements are made of mixed-muscle proteins in the whole body. Regarding the latter hypothesis, the synthetic rate of intramuscular connective tissue deserves scrutiny, because the frequency of several diseases linked to collagen-rich tissue, such as bone, connective tissue, and ligaments, seem to be sex specific (36). Women are at higher risk of suffering fibromyalgia, rheumatoid arthritis, and hypermobility and sustain more connective tissue injuries than men, and this may be related to exposure to different sex hormones. Estrogen and progesterone receptors hav...

show abstract

Characterization of the cytosolic estrogen receptor in rat skeletal muscle

Cited by 65 publications

References 36 publications

Effects of trenbolone acetate and zeranol on protein metabolism in male castrate andfemale lambs

Effects of trenbolone acetate and zeranol on protein metabolism in male castrate andfemale lambs

Effect of menopausal status on body composition and abdominal fat distribution

No effect of menstrual cycle on myofibrillar and connective tissue protein synthesis in contracting skeletal muscle

Contact Info

Product

Resources

About