Characterization of the discriminative stimulus effects of the NOP agonist Ro 64-6198 in non-human primates

Opioid receptors (MOP-r, KOP-r, DOP-r, as well as NOP-r) and their endogenous neuropeptide agonist systems are involved in diverse neurobiological and behavioral functions, in health and disease. These functions include pain and analgesia, addictions, and psychiatric diseases (e.g., depression-, anxiety-like, and stress-related disorders). Drug discrimination assays have been used to characterize the behavioral pharmacology of ligands with affinity at MOP-r, KOP-r, or DOP-r (and to a lesser extent NOP-r). Therefore, drug discrimination studies with opioid ligands have an important continuing role in translational investigations of diseases that are affected by these neurobiological targets and their pharmacotherapy.

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Discriminative Stimulus Properties of Opioid Ligands: Progress and Future Directions

Butelman

Kreek

2016

The Behavioral Neuroscience of Drug Discrimination

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Characterization of the discriminative stimulus effects of the NOP agonist Ro 64-6198 in non-human primates

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Discriminative Stimulus Properties of Opioid Ligands: Progress and Future Directions

Discriminative Stimulus Properties of Opioid Ligands: Progress and Future Directions

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