Characterization of the effect of serum bilirubin concentrations on coronary endothelial function via measurement of high-sensitivity C-reactive protein and high-density lipoprotein cholesterol

Yoshino, Satoshi; Hamasaki, Shuichi; Ishida, Susumu; Kataoka, Tetsuro; Yoshikawa, Akiko; Oketani, Naoya; Saihara, Keishi; Ichiki, Hitoshi; Kuwahata, So; Fujita, Shoji; Takumi, Takuro; Yoshimoto, Issei; Nakazaki, Mitsuhiro

doi:10.1007/s00380-011-0228-z

Cited by 15 publications

(13 citation statements)

References 33 publications

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“…Flow-mediated dilation was significantly greater in overweight patients with the greatest bilirubin concentrations (Ͼ0.77 mg/dl), further suggesting that bilirubin protects against endothelial dysfunction (197). Elevated serum bilirubin concentrations are also associated with improved endothelium-dependent function of coronary arteries in patients without coronary heart disease (CHD) (196). Acetylcholine-mediated increases in coronary blood flow (CBF) and coronary artery diameter were positively correlated with serum bilirubin concentrations.…”

Section: Potential Protective Effects Of Bilirubinmentioning

confidence: 96%

“…Acetylcholine-mediated increases in coronary blood flow (CBF) and coronary artery diameter were positively correlated with serum bilirubin concentrations. Furthermore, hs-CRP and HDL were independent predictors correlating with serum bilirubin concentrations and therefore suggested that bilirubin may mediate these effects by reducing inflammation and increasing HDL availability (196). The reported beneficial effect of bilirubin on lipid status was recently reviewed, indicating bilirubin might have discrete effects on cholesterol metabolism (20).…”

Section: Potential Protective Effects Of Bilirubinmentioning

confidence: 98%

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Circulating bilirubin and defense against kidney disease and cardiovascular mortality: mechanisms contributing to protection in clinical investigations

Boon

Bulmer

Coombes

et al. 2014

American Journal of Physiology-Renal Physiology

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Unconjugated bilirubin is an endogenous circulating antioxidant, bound to albumin, and therefore is retained in the vascular compartment. Bilirubin has well-documented neurotoxic effects in infants; however, current evidence indicates mildly elevated bilirubin is associated with protection from cardiovascular disease and all-cause mortality in adults. Recent clinical studies show mildly elevated bilirubin is associated with protection from kidney damage and dysfunction, in addition to cardiovascular events and all-cause mortality in patients undergoing hemodialysis. This is the first review to examine the clinical evidence and summarize the potential mechanisms of action that link bilirubin to protection from kidney damage, subsequent kidney failure, and dialysis-related mortality. With this understanding, it is hoped that new therapies will be developed to prevent renal dysfunction and mortality from cardiovascular disease in at-risk individuals.

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Section: Potential Protective Effects Of Bilirubinmentioning

confidence: 96%

Section: Potential Protective Effects Of Bilirubinmentioning

confidence: 98%

Circulating bilirubin and defense against kidney disease and cardiovascular mortality: mechanisms contributing to protection in clinical investigations

Boon

Bulmer

Coombes

et al. 2014

American Journal of Physiology-Renal Physiology

View full text Add to dashboard Cite

show abstract

“…In a populationbased study using measurement of hsCRP as an indicator of inflammation, a high level of bilirubin was found to be associated with favorable coronary endothelial function [121]. Low bilirubin levels were found to inversely correlate with high coronary artery calcification and reduced hsCRP level [122].…”

Section: Bilirubin and Inflammationmentioning

confidence: 98%

The pharmacological features of bilirubin: the question of the century

Zahir

Rabbani

Khan

et al. 2015

Cellular and Molecular Biology Letters

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This review looks at the toxicity and metabolism of bilirubin in terms of its pharmacological potential. Its role has gained importance as more research has revealed the functional significance and interrelationship between the gasotransmitters nitric oxide and carbon monoxide. The biological actions of bilirubin have mostly been characterized in the high micromolar range where toxic effects occur. However, it could also prove to be an important cytoprotector for brain tissue, which is inherently less equipped for antioxidant defense. Plasma bilirubin levels negatively correlate to a number of disease states. Higher levels of bilirubin that are still within the normal range provide a protective effect to the body. The effects on various disorders could be tested using controlled pharmacological upregulation of the molecule with animal models. At nanomolar concentrations, considerable benefits have been obtained when the molecule was delivered pharmacologically under in vitro or in vivo test conditions, particularly in neurodegenerative disorders and after tissue or organ transplantation. The induction of heme oxygenase-1 (HMOX-1) via the activation of nuclear factor erythroid 2-related factor or the use of bile pigments in the harvesting of diseased tissue are novel applications, and like every new therapy, should be used with caution. HMOX-1 is tissue specific, and in exceptional states, such as schizophrenia and specific types of renal disorder, the same therapy may have disastrous effects.

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“…Other studies have shown that higher plasma total cholesterol, higher triglycerides, increased small dense LDL and lower high density lipoprotein (HDL) cholesterol are related to lower bilirubin levels [9,[20][21][22], although such relationships have not been consistently reported [23].…”

Section: Introductionmentioning

confidence: 99%

Increased large VLDL and small LDL particles are related to lower bilirubin in Type 2 diabetes mellitus

Dullaart¹,

Vries²,

Lefrandt³

2014

Clinical Biochemistry

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Characterization of the effect of serum bilirubin concentrations on coronary endothelial function via measurement of high-sensitivity C-reactive protein and high-density lipoprotein cholesterol

Cited by 15 publications

References 33 publications

Circulating bilirubin and defense against kidney disease and cardiovascular mortality: mechanisms contributing to protection in clinical investigations

Circulating bilirubin and defense against kidney disease and cardiovascular mortality: mechanisms contributing to protection in clinical investigations

The pharmacological features of bilirubin: the question of the century

Increased large VLDL and small LDL particles are related to lower bilirubin in Type 2 diabetes mellitus

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