Characterization of the Gut Microbiota in Urban Thai Individuals Reveals Enterotype-Specific Signature

Sinsuebchuea, Jiramaetha; Paenkaew, Prasobsook; Wutthi-in, Montree; Nantanaranon, Thatchawanon; Laeman, Kiattiyot; Kittichotirat, Weerayuth; Wattanachaisaereekul, Songsak; Dulsawat, Sudarat; Nopharatana, Montira; Vorapreeda, Namol; Bhumiratana, Sakarindr; Cheevadhanarak, Supapon; Sutheeworapong, Sawannee

doi:10.3390/microorganisms11010136

Cited by 3 publications

(1 citation statement)

References 125 publications

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“…Interestingly, the stability of the GM was also confirmed at the level of individual strains (33). Accordingly, pioneering research in this field already attempted to identify characteristic eubiotic states of the GM, leading to the concept of enterotypes -recurrent patterns of GM composition dominated by particular bacterial taxa -that correlate most strongly with long-term dietary habits (31,34).…”

Section: Gut Microbiota Enterotypesmentioning

confidence: 99%

Crosstalk between vitamin status and gut microbiota: The key to maintaining immune homeostasis in the gut

Rakić,

Repac,

Lunić

et al. 2023

Arhiv za farmaciju

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The human gut microbiota is a diverse ecosystem that harbours a variety of microorganisms, including proteobacteria, bacteria, viruses, fungi, protists, and archaea. These microorganisms are collectively involved in several vital functions, including nutrient metabolism, vitamin synthesis, immune system regulation, neurotransmitter production, drug metabolism, and communication with the central nervous system. Dysbiosis within the gut microbiota has been shown to be a critical factor in the development of chronic disease. Investigating the effects of gut microbiota composition on overall health holds promise for the treatment of inflammatory diseases and the development of new therapeutic interventions. One notable aspect of the functionality of the gut microbiota is its involvement in the production of essential B vitamins. These vitamins exert a significant influence on immune responses and the composition of the gut microbiota. Competition may occur between the host and the gut microbiota for B vitamins, which some bacteria obtain from food or from synthesis by other gut bacteria. Thus, the availability of B vitamins in the diet has the potential to influence the composition of the gut microbiota and thus immune homeostasis. The profile of the gut microbiota varies individually, with diet proving to be an important modulator of both its composition and functional properties. However, further extensive research efforts are needed to understand the complex interplay between the gut microbiota, vitamins, and immune response mechanisms. Such investigations have the potential to develop innovative therapeutic strategies for a spectrum of inflammatory diseases, opening new avenues for improved patient outcomes.

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Section: Gut Microbiota Enterotypesmentioning

confidence: 99%

Crosstalk between vitamin status and gut microbiota: The key to maintaining immune homeostasis in the gut

Rakić,

Repac,

Lunić

et al. 2023

Arhiv za farmaciju

View full text Add to dashboard Cite

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Alleviation of migraine through gut microbiota-brain axis and dietary interventions: Coupling epigenetic network information with critical literary survey

Prathiviraj,

Adithya,

Rajeev

et al. 2023

Trends in Food Science & Technology

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Impact of urbanization on gut microbiome mosaics across geographic and dietary contexts

Vinogradova,

Mukhanbetzhanov,

Nurgaziyev

et al. 2024

mSystems

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This study provides a comprehensive assessment of how urban-rural divides influence gut microbial diversity and composition across the distinct geographical landscapes of Kazakhstan, elucidating the intricate interplay between lifestyle, environment, and gut microbiome. In this prospective cohort study, we enrolled 651 participants from urban centers and rural settlements across Kazakhstan, following ethical approval and informed consent. Comprehensive demographic, dietary, and stool sample data were collected. 16S rRNA gene sequencing and shotgun metagenomics techniques were employed to delineate the intricate patterns of the gut microbiome. A rigorous statistical framework dissected the interplay between urbanization gradients, geography, dietary lifestyles, and microbial dynamics. Our findings demonstrate a stark microbial divide between urban and rural gut ecosystems. The study found significant differences in gut microbiome diversity and composition between urban and rural populations in Kazakhstan. Urban microbiomes exhibited reduced diversity, higher Firmicutes/Bacteroidetes ratios, and increased prevalence of genera Coprococcus and Parasutterella . In contrast, rural populations had greater microbial diversity and abundance of Ligilactobacillus , Sutterella , and Paraprevotella . Urbanization also influenced dietary patterns, with urban areas consuming more salt, cholesterol, and protein, while rural areas had diets richer in carbohydrates and fiber. The study also identified distinct patterns in the prevalence of antibiotic resistance genes and virulence factors between urban and rural gut microbiomes. This study sheds light on how urbanization may be deeply involved in shaping the intricate mosaic of the gut microbiome across Kazakhstan’s diverse geographical and dietary landscapes, underscoring the complex interplay between environmental exposures, dietary lifestyles, and the microbial residents inhabiting our intestines. IMPORTANCE The study examined gut microbiome composition across diverse geographical locations in Kazakhstan, spanning urban centers and rural settlements. This allows for thoroughly investigating how urbanization gradients and geographic factors shape the gut microbiome. The study's examination of the gut resistome and prevalence of virulence-associated genes provide essential insights into the public health implications of urbanization-driven microbiome alterations. Collecting comprehensive demographic, dietary, and stool sample data enables the researchers to better understand the relationships between urbanization, nutritional patterns, and gut microbiome composition. The findings have important implications for understanding how urbanization-driven microbiome changes may impact human health and well-being, paving the way for tailored interventions to restore a balanced gut microbial ecology.

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Characterization of the Gut Microbiota in Urban Thai Individuals Reveals Enterotype-Specific Signature

Cited by 3 publications

References 125 publications

Crosstalk between vitamin status and gut microbiota: The key to maintaining immune homeostasis in the gut

Crosstalk between vitamin status and gut microbiota: The key to maintaining immune homeostasis in the gut

Alleviation of migraine through gut microbiota-brain axis and dietary interventions: Coupling epigenetic network information with critical literary survey

Impact of urbanization on gut microbiome mosaics across geographic and dietary contexts

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