Characterization of the Humoral Immune Response to Bovine Collagen Implants

Immunologic Aspects of Bovine Injectable Collagen in Humans

“…These observations stand in contrast to those of McCoy [21] and Frank et al [19] who demonstrated increased antibody titers as repeated injections were given. Further, the 28% antibody response rate to periurethral collagen injection [20], compared with the 10% response rate to dermal collagen, may be explained by the large amounts used for treatment of urinary incontinence.…”

“…Subtyping studies showed that all patients had antibodies of the IgG (80–100% of sera samples) or IgA (40–50% of samples) subtype [19, 20, 21]; no IgM or IgE subtypes were detected in any of the patients [19]. Immune complexes were not found in the serum of patients reacting to the implant material [27].…”

Generalized destructive, ulcerating and debilitating necrobiosis lipoidica sine diabetes in a young male recalcitrant to therapy

“…Dahl suggested that NL may fit into this list of associated autoimmune diseases |7|, He and Quimby [8], detected IgM and immune complexes in NL lesions and proposed deposition of immune complexes in the dermal microvessels as the primary event in NL. In our patient no depositions of C3, IgG or IgM were detected in direct immunofluorescence, A defective ultrastructure of collagen showing a loss of typical crossstriation was demonstrated in NL [9], This and the finding of elevated circulating anti-bovine collagen antibodies in response to implanted bovine collagen [10] lead to the assumption that necrobiotic human collagen may act as an immune stimulator in NL. Therefore the author proposes, that vascular changes encountered in the lower limb lesions of ordinary necrobiosis are probably not primary in origin, but secondary to factors like arteriosclerosis.…”

Cutaneous Hypersensitivity Reaction to Injectable Hyaluronic Acid Gel

“…5,6 Since its approval in the early 1980s, however, bovine collagen has been the mainstay of therapy for correction of facial contour defects, atrophic scars, and wrinkles. [5][6][7][8][9] This reaction usually subsides within 6 months, but has been reported to last up to 18 months in some people. Approximately 3% of patients will experience an allergic reaction to injected bovine collagen with development of circulating antibodies to the foreign material.…”