Characterization of the immune response in the synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome

Hurtado-Nédelec, Margarita; Chollet‐Martin, Sylvie; Nicaise-Roland, Pascale; Grootenboer‐Mignot, Sabine; Ruimy, Raymond; Meyer, Olivier; Hayem, Gilles

doi:10.1093/rheumatology/ken185

Cited by 145 publications

(112 citation statements)

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“…In addition, IgA upregulation has been previously reported in a cohort of 29 SAPHO patients [4,5] . In our report, IgA was also upregulated; hence, it could be useful for the definitive diagnosis of SAPHO syndrome.…”

Section: Discussionmentioning

confidence: 74%

SAPHO syndrome in which certolizumab pegol was effective: A case report

et al. 2017

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A 45-year-old male suffered from persistent swelling and redness, with pain in his left lower leg and ankle. Pathological findings isolated from the ankle joint by arthroscopic synovectomy showed mild synovitis. Initially, this case was diagnosed as chronic mild arthritis and later treated as phlegmon because of the persistent redness and swelling inflammatory findings in his left lower leg. A systemic survey was performed. Based on the findings-such as chronic ankle arthritis with ipsilateral plantar pustulosis, chronic recurrent multifocal osteomyelitis in left distal tibia with magnetic resonance imaging (MRI), calcaneal osteitis with computed tomography, and pathological findings that neither malignant tumor nor infection was detected-this case reached the definitive diagnosis of SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome. The hot spots detected in the bilateral sternoclavicular and costosternal joints with bone scintigraphy and their arthritic change detected by computed tomography also supported the diagnosis of SAPHO syndrome. This case was refractory to nonsteroidal antiinflammatory drugs (NSAIDS); therefore, the TNF inhibitor certolizumab pegol was tried. This agent rapidly improved not only the chief complaints but also the objective symptoms and laboratory findings at most six weeks after its administration.

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Section: Discussionmentioning

confidence: 74%

SAPHO syndrome in which certolizumab pegol was effective: A case report

et al. 2017

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“…In etwa 3 -7,5 % der Fälle kann es zu einer chronisch entzündlichen Darmerkrankung kommen, wobei der Morbus Crohn häufiger als die Colitis ulcerosa ist [9]. Die Ätiologie der Erkrankung ist weitgehend unbekannt, diskutiert wird aber eine mögliche Triggerung durch Propionibacterium acnes [7]. Außerdem werden immunologische und hereditäre Faktoren bei der Pathogenese des SAPHO-Syndroms diskutiert [9].…”

Section: Rezidivierende Multifokale Osteomyelitis Ohne Dermatoseunclassified

Rezidivierende multifokale Osteomyelitis ohne Dermatose

Lamparter¹,

List-Hellwig²,

Basten³

2013

Dtsch med Wochenschr

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“…In a large registry, serum concentrations of TNF-a were increased in two-thirds of patients with active disease 1 . Increased TNF-a expression was observed in biopsies obtained from osteolytic lesions of 2 adults with SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome, a disorder that presents mainly in adulthood and produces bony lesions similar to those of CRMO 8 . TNF-a promotes osteoclast activation in vitro, representing a possible mechanism by which local TNF-a overexpression may contribute to osteolysis 9 .…”

Section: Casementioning

confidence: 99%