Characterization of the Immune Response in Subjects with Self-Healing Cutaneous Leishmaniasis

Carvalho, Edgar M.; Correia, Dalmo; Bacellar, Olı́via; Almeida, Renata; Lessa, Hélio A.; Rocha, Hilda Carlos da

doi:10.4269/ajtmh.1995.53.273

Cited by 66 publications

(54 citation statements)

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“…8, a small percentage of both CD4+ and CD8+ cells were producing IFN-γ before treatment was initiated, both in the IC and the CH groups. At the end of treatment, however, cytometric analysis of stimulated Montenegro's skin test were positive in 88% of the cases, supporting previous observations from our group as well as from other studies (Carvalho et al 1995, da Costa et al 1996, thus confirming the validity of this test as a helpful diagnostic tool in leishmaniasis.…”

Section: Discussionsupporting

confidence: 79%

“…Our study focused primarily on the production of IFN-γ by these cells due to the involvement of this cytokine in resistance to and recovery from leishmanial infections (Carvalho et al 1995, Coutinho et al 1998, Ribeirode-Jesus et al 1998. When analyzing the production of this cytokine before treatment onset it was observed that cells from patients with chronic lesions produced more IFN-γ than those from patients with recent infections.…”

Section: Discussionmentioning

confidence: 99%

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Immunochemotherapy in American cutaneous leishmaniasis: immunological aspects before and after treatment

Toledo

Mayrink

Gollob

et al. 2001

Mem. Inst. Oswaldo Cruz

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Immunochemotherapy in American cutaneous leishmaniasis: immunological aspects before and after treatment

Toledo

Mayrink

Gollob

et al. 2001

Mem. Inst. Oswaldo Cruz

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“…It is also expected that T cell responses and monocyte function are important in the control of L. braziliensis infection. In fact, there is evidence of a Th1 type of response in subjects with subclinical L. braziliensis infection and in subjects with self-healing cutaneous leishmaniasis (37). The observation presented here that, early in the infection, T cell response is depressed in cutaneous leishmaniasis may indicate that, after infection, there is an absence of IFN-γ production that allows parasite multiplication.…”

mentioning

confidence: 59%

Cytokine profile and pathology in human leishmaniasis

Ribeiro-de-Jesus

Almeida

Lessa

et al. 1998

Braz J Med Biol Res

192

190

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The clinical spectrum of leishmaniasis and control of the infection are influenced by the parasite-host relationship. The role of cellular immune responses of the Th1 type in the protection against disease in experimental and human leishmaniasis is well established. In humans, production of IFN-γ is associated with the control of infection in children infected by Leishmania chagasi. In visceral leishmaniasis, an impairment in IFN-γ production and high IL-4 and IL-10 levels (Th2 cytokines) are observed in antigen-stimulated peripheral blood mononuclear cells (PBMC). Moreover, IL-12 restores IFN-γ production and enhances the cytotoxic response. IL-10 is the cytokine involved in down-regulation of IFN-γ production, since anti-IL-10 monoclonal antibody (mAb) restores in vitro IFN-γ production and lymphoproliferative responses, and IL-10 abrogates the effect of IL-12. In cutaneous and mucosal leishmaniasis, high levels of IFN-γ are found in L. amazonensis-stimulated PBMC. However, low or absent IFN-γ levels were observed in antigen-stimulated PBMC from 50% of subjects with less than 60 days of disease (24 ± 26 pg/ml). This response was restored by IL-12 (308 ± 342 pg/ml) and anti-IL-10 mAb (380 ± 245 pg/ml) (P<0.05). Later during the disease, high levels of IFN-γ and TNF-α are produced both in cutaneous and mucosal leishmaniasis. After treatment there is a decrease in TNF-α levels (366 ± 224 pg/ml before treatment vs 142 ± 107 pg/ml after treatment, P = 0.02). Although production of IFN-γ and TNF-α might be involved in the control of parasite multiplication in the early phases of Leishmania infection, these cytokines might also be involved in the tissue damage seen in tegumentary leishmaniasis.Correspondence

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“…No differences in lesion healing between men and women were found, despite the findings of Travi et al (2002), who studied hamsters infected with Leishmania (Viannia) and observed that the immune response was more permissive to infection among males than females. The factors that contribute to the cutaneous disease evolving into one of the later forms are not fully understood, but delay in healing the first lesion and inadequate treatment are both known predictors (Carvalho et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Variables associated with the post-treatment healing of lesions in patients with American cutaneous leishmaniasis in Paraná State, Brazil

Casavechia

Silveira

Teodoro

et al. 2009

Braz. J. Pharm. Sci.

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The purpose of this study was to investigate the relationship of several variables to the healing of lesions in patients with American cutaneous leishmaniasis (ACL). The patients with clinical and/or laboratorial diagnoses of the disease were followed up for varying periods after treatment by clinical evaluation and indirect immunofluorescence assay (IFA), from September 2000 to December 2003. The lesions of 85.3% of the 163 patients had healed by their last return for clinical evaluation, and of these, 82.7% had negative IFA results, indicating an association between the healing of lesions and IFA negativity (p=0.000). In patients evaluated up to 120 days after treatment, there was a significant association between negative IFA results and the healing of lesions (p=0.0000). Logistic regression analysis showed that negative IFA results on patients' first return after treatment predicted a 2.175 fold greater chance of lesion healing (p=0.0001). These results indicate an association between IFA negativity at the first return up to a period of 120 days, and the healing of lesions, and that the chances of healing are significantly higher in patients with negative IFA results at their first return after treatment.Uniterms: Cutaneous leishmaniasis/treatment. Leishmania (Viannia) braziliensis. Cutaneous lesion/ healing. O objetivo deste estudo foi investigar a associação de algumas variáveis para a cicatrização de lesões em pacientes com leishmaniose tegumentar americana (LTA). Os pacientes com diagnóstico clínico e laboratorial foram acompanhados depois do tratamento por avaliação clínica e reação de imunofluorescência indireta (IFI), de setembro de 2000 a dezembro de 2003. Dos 163 pacientes 85,3% apresentaram cicatrização das lesões no último retorno para a avaliação clínica e 82,7% destes tiveram a IFI negativa indicando uma associação entre a cicatrização das lesões e a negativação da IFI (p=0,000). Nos pacientes acompanhados até 120 dias depois do tratamento houve associação significativa entre os resultados negativos da IFI e a cicatrização das lesões (p=0,0000). A análise pela regressão logística mostrou que quando a IFI do primeiro retorno após o tratamento foi negativa, o paciente tinha 2,175 mais chance de cicatrização (p=0,0001). Os resultados mostram associação entre a negativação da IFI e a cicatrização das lesões quando o primeiro retorno foi até 120 dias e que as chances de cicatrização são significativamente maiores nos pacientes que apresentaram IFI negativa no primeiro retorno depois do tratamento.Unitermos: Leishmaniose cutânea/tratamento. Leishmania (Viannia) braziliensis. Lesão cutânea/ cicatrização.

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Characterization of the Immune Response in Subjects with Self-Healing Cutaneous Leishmaniasis

Cited by 66 publications

References 0 publications

Immunochemotherapy in American cutaneous leishmaniasis: immunological aspects before and after treatment

Immunochemotherapy in American cutaneous leishmaniasis: immunological aspects before and after treatment

Cytokine profile and pathology in human leishmaniasis

Variables associated with the post-treatment healing of lesions in patients with American cutaneous leishmaniasis in Paraná State, Brazil

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