2019
DOI: 10.1080/08927014.2019.1675153
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Characterization of the immunomodulatory and anti-Helicobacter pylori properties of the human gastric isolate Lactobacillus rhamnosus UCO-25A

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Cited by 8 publications
(11 citation statements)
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“…Earlier studies reported that L. salivarius WB 1004 [35], L. rhamnosus R0011 and L. acidophilus R0052 [36] were able to differentially modulate immune responses and diminish H. pylori colonization in mice. The beneficial modulation of the inflammatory immune response and the reduction of H. pylori adhesion has been also reported in in vitro experiments for probiotic strains such as L. bulgaricus [37] and L. rhamnosus UCO-25A [38]. Moreover, studies have proposed the inactivation of Smad7 and NF-κB signaling pathways [39] and the activation of SOCS-2/SOCS-3 signaling through STAT1/STAT3 activation and JAK2 inactivation [40] as the molecular mechanisms of action for the beneficial effects of probiotics.…”
Section: Discussionmentioning
confidence: 64%
“…Earlier studies reported that L. salivarius WB 1004 [35], L. rhamnosus R0011 and L. acidophilus R0052 [36] were able to differentially modulate immune responses and diminish H. pylori colonization in mice. The beneficial modulation of the inflammatory immune response and the reduction of H. pylori adhesion has been also reported in in vitro experiments for probiotic strains such as L. bulgaricus [37] and L. rhamnosus UCO-25A [38]. Moreover, studies have proposed the inactivation of Smad7 and NF-κB signaling pathways [39] and the activation of SOCS-2/SOCS-3 signaling through STAT1/STAT3 activation and JAK2 inactivation [40] as the molecular mechanisms of action for the beneficial effects of probiotics.…”
Section: Discussionmentioning
confidence: 64%
“…The capacity of both strains to modulate the immune response as the result of an infection by Helicobacter pylori has been evaluated in AGS cells (human gastric adenocarcinoma cell line) and THP-1 cells (human monocytic cell line). Both cell lines were demonstrated to increase the IL-10 and IFN-γ anti-inflammatory response as well as reduce the TNF-α IL-8 and IL-1b proinflammatory response, being the preventive model that provided the best results [ 115 , 116 , 117 ]. This is an important issue because the reduced production of inflammatory factors, particularly IL-8 and TNF-α, is associated with a less serious infection and ensuing sequels [ 115 , 117 ].…”
Section: Resultsmentioning
confidence: 99%
“…Production of IL-10 is a marker of an anti-inflammatory response to Lactobacillus . This interleukin has previously been shown to be induced by Lactobacillus in other cell types including macrophage cell lines (RAW264.7 (mouse) and THP-1(human)), cervical tumor cells (HeLa), and colonic epithelial cells (Caco2) [ 36 , 44 , 45 ]. However, we observed little production of IL-10 in mock or following infection with all four strains of Lactobacillus in our study.…”
Section: Discussionmentioning
confidence: 99%